Inhibitor | RO-31-8220  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
RO-31-8220   C25H23N5O2S • CH4O3S 553.70 125314-64-9 11628205 PKC Trapp J. (2006) J. Med. Chem. 49 7307-16 Powell D.J. (2003) Mol. Cell Biol. 23 7794

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
AMPK 26 8
Aurora B 86 5
Aurora C 73 3
BRSK2 65 2
CAMK1 90 0
CAMKK alpha 114 1
CAMKK beta 68 3
CDK2-Cyclin A
3
 0
CHK1 53 2
CHK2 107 2
CK1 delta 93 6
CK2 99 5
CSK 75 5
DYRK1A 36 1
DYRK2 90 1
DYRK3 63 7
EF2K 115 1
ERK1 91 1
ERK2 98 1
ERK8 54 0
GSK3 beta
4
 0
HIPK2 47 7
HIPK3 86 8
IKK beta 91 3
JNK1 98 2
JNK2 93 2
JNK3 113 0
Lck 64 1
MAPKAP-K2 90 7
MAPKAP-K3 89 0
MARK3 72 1
MELK 51 5
MKK1 64 0
MNK1 89 2
MNK2 110 1
MSK1 12 2
MST2 21 4
NEK2a 87 1
NEK6 106 5
NEK7 108 2
p38 alpha MAPK 108 2
p38 beta MAPK 114 1
p38 delta MAPK 91 1
p38 gamma MAPK 100 6
PAK4 83 1
PAK5 74 6
PAK6 84 0
PDK1 53 2
PHK 43 3
PIM1 45 7
PIM2 30 1
PIM3 11 0
PKA 58 1
PKB alpha 63 2
PKB beta 69 2
PKC alpha
3
 0
PKC zeta 33 3
PKD1 77 5
PLK1 80 0
PRAK 80 9
PRK2
8
 2
ROCK 2 95 5
RSK1 11 5
RSK2
3
 1
S6K1 20 0
SGK1 47 0
SmMLCK 51 0
Src 92 6
SRPK1 80 7
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 88 0
AMPK 39 13
ASK1 90 1
Aurora A 93 2
Aurora B 31 4
BRK 84 8
BRSK1 38 1
BRSK2 37 8
BTK 40 3
CAMK1 38 6
CAMKK beta 13 1
CDK2-Cyclin A
4
 1
CHK1 12 3
CHK2 34 6
CK1 delta 94 5
CK2 93 15
CLK2
1
 0
CSK 95 8
DAPK1 43 5
DYRK1A
4
 1
DYRK2 86 8
DYRK3 18 1
EF2K 79 5
EPH-A2 57 4
EPH-A4 53 3
EPH-B1 83 2
EPH-B2 57 1
EPH-B3 91 21
EPH-B4 74 4
ERK1 85 1
ERK2 88 8
ERK8
3
 1
FGF-R1 40 24
GCK 15 0
GSK3 beta
1
 1
HER4 40 4
HIPK1 23 2
HIPK2 14 1
HIPK3 47 5
IGF-1R 41 3
IKK beta 84 3
IKK epsilon 75 7
IR 101 0
IRAK4 40 4
IRR 23 0
JAK2 55 4
JNK1 76 3
JNK2 79 6
JNK3 91 8
Lck 56 6
LKB1 77 5
MAPKAP-K2 75 8
MAPKAP-K3 92 20
MARK1 75 7
MARK2 61 23
MARK3 80 37
MARK4 72 3
MEKK1 84 13
MELK 42 10
MINK1
9
 1
MKK1 28 0
MKK2 24 5
MKK6 74 2
MLK1 66 43
MLK3
7
 1
MNK1 94 4
MNK2 107 7
MPSK1 103 1
MSK1
1
 0
MST2 16 3
MST4 21 1
NEK2a 85 4
NEK6 85 12
NUAK1 19 1
p38 alpha MAPK 85 8
p38 beta MAPK 92 4
p38 delta MAPK 84 8
p38 gamma MAPK 91 6
PAK2 84 13
PAK4 49 2
PAK5 75 5
PAK6 78 11
PDK1 30 4
PHK
8
 1
PIM1
6
 2
PIM2 14 3
PIM3 32 44
PKA 21 1
PKB alpha 13 1
PKB beta 13 1
PKC alpha
4
 0
PKC gamma 39 2
PKC zeta
6
 0
PKD1 38 5
PLK1 95 13
PRAK 92 0
PRK2
3
 1
RIPK2 89 4
ROCK 2 70 3
RSK1
4
 1
RSK2
1
 0
S6K1
2
 0
SGK1
6
 1
SmMLCK 11 0
Src 89 5
SRPK1 29 1
STK33
10
 2
SYK 69 5
TAK1 37 7
TAO1 34 8
TBK1 28 2
TIE2 89 7
TrkA
7
 1
TTK 35 2
VEGFR1
5
 1
YES1 41 10
ZAP70 73 3
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
ABL 59 3
AMPK 17 4
ASK1 68 3
Aurora A 65 1
Aurora B 24 5
BRK 68 8
BRSK1 24 1
BRSK2 15 0
BTK
10
 0
CAMK1 11 9
CAMKK beta
5
 0
CDK2-Cyclin A
3
 1
CHK1
5
 2
CHK2
6
 1
CK1 delta 98 1
CK2 80 8
CLK2
0
 0
CSK 70 2
DAPK1
6
 0
DYRK1A
3
 2
DYRK2 62 4
DYRK3
3
 0
EF2K 88 10
EPH-A2 20 1
EPH-A4 19 0
EPH-B1 52 27
EPH-B2 22 1
EPH-B3 63 0
EPH-B4 38 1
ERK1 45 1
ERK2 59 2
ERK8
3
 1
FGF-R1 13 5
GCK
4
 0
GSK3 beta
1
 0
HER4 15 3
HIPK1
8
 0
HIPK2
8
 0
HIPK3 15 0
IGF-1R
2
 0
IKK beta 56 0
IKK epsilon 30 2
IR 52 15
IRAK4 16 2
IRR 19 5
JAK2 16 1
JNK1 48 6
JNK2 48 5
JNK3 57 1
Lck 12 2
LKB1 36 5
MAPKAP-K2 50 8
MAPKAP-K3 63 1
MARK1 44 3
MARK2 11 2
MARK3 16 4
MARK4 29 0
MEKK1 79 5
MELK 25 3
MINK1
3
 0
MKK1
7
 0
MKK2
7
 2
MKK6 60 1
MLK1 14 1
MLK3
3
 0
MNK1 80 8
MNK2 86 6
MPSK1 90 7
MSK1
0
 0
MST2
8
 2
MST4 15 9
NEK2a 83 1
NEK6 75 11
NUAK1
4
 0
p38 alpha MAPK 58 6
p38 beta MAPK 68 1
p38 delta MAPK 42 2
p38 gamma MAPK 82 5
PAK2 43 7
PAK4 19 2
PAK5 30 1
PAK6 46 9
PDK1
10
 0
PHK
4
 1
PIM1
4
 0
PIM2
4
 0
PIM3
1
 0
PKA
4
 1
PKB alpha
2
 1
PKB beta
4
 1
PKC alpha
1
 1
PKC gamma 16 1
PKC zeta
3
 0
PKD1 25 5
PLK1 94 10
PRAK 79 7
PRK2
1
 0
RIPK2 70 6
ROCK 2 23 2
RSK1
2
 1
RSK2
1
 0
S6K1
2
 0
SGK1
2
 1
SmMLCK
3
 0
Src 129 10
SRPK1
6
 1
STK33
7
 1
SYK 23 1
TAK1
8
 3
TAO1
7
 2
TBK1
6
 1
TIE2 35 4
TrkA
1
 1
TTK 16 1
VEGFR1
2
 0
YES1 19 4
ZAP70 83 12