Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
WP1130   C19H18BrN3O 384.27 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085.
V Kapuria (2010) Cancer Res 70(22) 9265-9276

1.00 98
WP1130   C19H18BrN3O 384.27 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085.
V Kapuria (2010) Cancer Res 70(22) 9265-9276

5.00 92
CCT250862 NEK

1.00 17
Celastrol   C29H38O4 450.60 hsp90, ampk Kim JH. Cell Signal. (2013) 805-13

WO2007117466
 1.00 93
Crenolanib   C26H29N5O2 443.50 FLT3 Smith CC (2014 )Proc Natl Acad Sci U S A Apr 8 111(14) 5319-24


 1.00 45
LY364947   C17H12N4 272.31 TGF-β type-I Sawyer (2003) J.Med.Chem. 46 3953
Li (2006) J.Med.Chem. 49 2138

1.00 60
PD 0325901   C16H14F3IN2O4 482.19 MEK1 Bain J. (2007) Biochem J. 408 297–315.
Barrett SD. (2008) Bioorg. Med. Chem. Lett. 18 6501-6504.
WO2002006213
 1.00 100
SB-747651A C16H22N8O 342.40 Naqvi (2012) Biochem. J. 441 (347–357)


 10.00 96
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 92
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

0.10 100