Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Akt Inhibitor IV   C31H27IN4S 614.60 Akt Kau T. R. (2003) Cancer Cell 4 463


10.00 92
Akti 1/2   C34H29N7O 551.60 Akt1, Akt2 Logie L. (2007) Diabetes 2218-27
Barnett S.F. (2005) Biochem. J. 385 399
WO2013147649
1.00 87
Akti 1/2   C34H29N7O 551.60 Akt1, Akt2 Logie L. (2007) Diabetes 2218-27
Barnett S.F. (2005) Biochem. J. 385 399
WO2013147649
10.00 92
Akti 1/2   C34H29N7O 551.60 Akt1, Akt2 Logie L. (2007) Diabetes 2218-27
Barnett S.F. (2005) Biochem. J. 385 399
WO2013147649
100.00 97
Akti 1/2   C34H29N7O 551.60 Akt1, Akt2 Logie L. (2007) Diabetes 2218-27
Barnett S.F. (2005) Biochem. J. 385 399
WO2013147649
0.10 96
Alsterpaullone   C16H11N3O3 293.30 GSK3b, CDK5/p25, CDK1/cyclin B Leost M. (2000) Eur. J. Biochem. 267 5983
Schultz C. (1999) J. Med. Chem. 42 2909
EP20050109789
1.00 73
Amgen TBK 1 inhibitor (Compound II)   C28H35N7O4 533.62 TBK1 Ou Y.H. (2011) Molecular Cell 41 458-470


1.00 22
Amgen TBK 1 inhibitor (Compound II)   C28H35N7O4 533.62 TBK1 Ou Y.H. (2011) Molecular Cell 41 458-470


0.10 25
Amlexanox   C16H14N2O4 298.29 TBK1, IKKe

10.00 113
Amlexanox   C16H14N2O4 298.29 TBK1, IKKe

1.00 111