Inhibitor | LY364947  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
LY364947   C17H12N4 272.31 396129-53-6 447966 TGF-β type-I Sawyer (2003) J.Med.Chem. 46 3953 Li (2006) J.Med.Chem. 49 2138

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 60 6
AMPK 106 6
ASK1 99 2
Aurora A 101 9
Aurora B 87 3
BRK 86 8
BRSK1 109 12
BRSK2 108 0
BTK 95 7
CAMK1 120 1
CAMKK beta 87 4
CDK2-Cyclin A 100 3
CHK1 97 5
CHK2 95 5
CK1 delta 31 1
CK2 91 7
CLK2 94 7
CSK 110 6
DAPK1 103 4
DYRK1A 91 10
DYRK2 114 8
DYRK3 90 3
EF2K 104 1
EIF2AK3 94 1
EPH-A2 103 9
EPH-A4 104 4
EPH-B1 91 4
EPH-B2 117 8
EPH-B3 88 9
EPH-B4 111 2
ERK1 85 13
ERK2 77 9
ERK8 79 1
FGF-R1 71 0
GCK 71 3
GSK3 beta 79 15
HER4 98 1
HIPK1 95 7
HIPK2 87 1
HIPK3 116 10
IGF-1R 101 24
IKK beta 94 9
IKK epsilon 104 9
IR 88 5
IRAK1 105 8
IRAK4 92 14
IRR 97 16
JAK2 103 5
JNK1 84 1
JNK2 86 14
JNK3 85 0
Lck 86 11
LKB1 98 3
MAPKAP-K2 112 27
MAPKAP-K3 83 4
MARK1 93 2
MARK2 89 9
MARK3 91 14
MARK4 103 13
MEKK1 111 27
MELK 119 12
MINK1 44 8
MKK1 97 16
MKK2 90 6
MKK6 98 4
MLK1 86 2
MLK3 115 22
MNK1 101 0
MNK2 102 3
MPSK1 113 4
MSK1 97 8
MST2 95 3
MST4 87 6
NEK2a 94 0
NEK6 103 11
NUAK1 100 15
OSR1 105 16
p38 alpha MAPK 63 6
p38 beta MAPK 87 1
p38 delta MAPK 100 7
p38 gamma MAPK 99 2
PAK2 93 2
PAK4 98 4
PAK5 109 17
PAK6 106 3
PDK1 95 14
PHK 100 11
PIM1 100 12
PIM2 94 12
PIM3 68 6
PKA 105 3
PKB alpha 114 16
PKB beta 104 3
PKC alpha 103 7
PKC gamma 105 14
PKC zeta 94 9
PKD1 74 10
PLK1 104 12
PRAK 101 9
PRK2 92 8
RIPK2 16 4
ROCK 2 101 0
RSK1 99 1
RSK2 114 20
S6K1 87 4
SGK1 97 5
SmMLCK 112 2
Src 109 2
SRPK1 103 0
STK33 94 3
SYK 106 8
TAK1 84 17
TAO1 69 1
TBK1 117 7
TIE2 119 7
TLK1 99 4
TrkA 119 13
TTK 97 0
VEGFR1 25 1
YES1 81 17
ZAP70 111 12
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
ABL 14 3
AMPK 96 3
ASK1 108 10
Aurora A 93 4
Aurora B 61 4
BRK 30 1
BRSK1 69 0
BRSK2 92 6
BTK 61 16
CAMK1 84 6
CAMKK beta 85 23
CDK2-Cyclin A 84 5
CHK1 91 18
CHK2 81 9
CK1 delta 11 4
CK2 84 3
CLK2 77 3
CSK 92 9
DAPK1 91 4
DYRK1A 80 3
DYRK2 114 23
DYRK3 90 0
EF2K 77 5
EIF2AK3 86 14
EPH-A2 87 17
EPH-A4 106 7
EPH-B1 95 6
EPH-B2 98 1
EPH-B3 69 4
EPH-B4 93 1
ERK1 81 3
ERK2 73 7
ERK8 73 12
FGF-R1 50 4
GCK 30 2
GSK3 beta 71 26
HER4 93 13
HIPK1 95 16
HIPK2 89 2
HIPK3 113 2
IGF-1R 87 9
IKK beta 84 2
IKK epsilon 103 2
IR 92 1
IRAK1 84 4
IRAK4 85 15
IRR 86 7
JAK2 90 6
JNK1 93 1
JNK2 68 7
JNK3 57 4
Lck 39 4
LKB1 90 5
MAPKAP-K2 109 12
MAPKAP-K3 100 6
MARK1 89 2
MARK2 79 0
MARK3 78 14
MARK4 100 3
MEKK1 82 11
MELK 90 8
MINK1 16 10
MKK1 77 6
MKK2 83 4
MKK6 107 3
MLK1 76 5
MLK3 109 2
MNK1 69 4
MNK2 97 2
MPSK1 91 2
MSK1 74 2
MST2 91 6
MST4 91 10
NEK2a 83 6
NEK6 88 3
NUAK1 79 5
OSR1 104 10
p38 alpha MAPK 18 0
p38 beta MAPK 52 2
p38 delta MAPK 86 17
p38 gamma MAPK 78 7
PAK2 89 7
PAK4 110 7
PAK5 101 11
PAK6 96 9
PDK1 104 12
PHK 95 8
PIM1 97 3
PIM2 85 9
PIM3 71 8
PKA 87 8
PKB alpha 92 10
PKB beta 90 4
PKC alpha 96 10
PKC gamma 93 14
PKC zeta 83 11
PKD1 22 1
PLK1 100 7
PRAK 91 8
PRK2 82 1
RIPK2
7
 1
ROCK 2 91 1
RSK1 93 11
RSK2 116 30
S6K1 84 9
SGK1 90 4
SmMLCK 104 9
Src 72 4
SRPK1 97 5
STK33 85 12
SYK 103 24
TAK1 41 1
TAO1 78 8
TBK1 105 1
TIE2 111 12
TLK1 98 4
TrkA 90 27
TTK 88 8
VEGFR1
7
 1
YES1 48 6
ZAP70 109 8