Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
ARA014418   C12H12N4O4S 308.30 GSK3 Noble W. (2005) Proc. Natl. Acad. Sci. USA 102 6990
Bhat R. (2003) J. Biol. Chem. 278 45937
WO2013124413
 10.00 72
AS601245 (JNK Inhibitor V)   C20H16N6S 372.50 JNK Gaillard P. (2005) J. Med. Chem. 48 4596
Carboni S. (2005) J. Neurochem. 92 1054
WO2013152038
 1.00 82
AS601245 (JNK Inhibitor V)   C20H16N6S 372.50 JNK Gaillard P. (2005) J. Med. Chem. 48 4596
Carboni S. (2005) J. Neurochem. 92 1054
WO2013152038
 10.00 70
AX 20017   C13H16N2O2S 264.34 PknG Walburger A (2004) Science 304 1800-1804


1.00 103
AX 20017   C13H16N2O2S 264.34 PknG Walburger A (2004) Science 304 1800-1804


10.00 86
AZD8055   C25H31N5O4 465.50 mTOR C1, mTOR C2 Chresta C.M. (2010) Cancer Res. 70 288-298
Sini P. (2010) Autophagy 6(4)

0.10 98
AZD8055   C25H31N5O4 465.50 mTOR C1, mTOR C2 Chresta C.M. (2010) Cancer Res. 70 288-298
Sini P. (2010) Autophagy 6(4)

1.00 100
BAY 61-3606 C20H18N6O3 · xHCl · yH2O 390.40 Syk Yamamoto N. (2003) J. Pharmacol. Exp. Ther. 306 1174-1181


 1.00 87
BAY 61-3606 C20H18N6O3 · xHCl · yH2O 390.40 Syk Yamamoto N. (2003) J. Pharmacol. Exp. Ther. 306 1174-1181


 10.00 101
Bay 65-1942   C22H26ClN3O4 431.91 IKKb Ziegelbauer K. (2005) British Journal of Pharmacology 145 178-192 (compound A)
Moss N.C. (2007) Am J Physiol Heart Circ Physiol 293 H2248-53

10.00 54