Inhibitor | Crenolanib  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Crenolanib   C26H29N5O2 443.50 670220-88-9 10366136 FLT3 Smith CC (2014 )Proc Natl Acad Sci U S A Apr 8 111(14) 5319-24

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 45 1
AMPK (hum)
2
 1
ASK1 108 3
Aurora A 106 5
Aurora B 23 6
BRK 111 19
BRSK1 30 0
BRSK2 41 4
BTK 113 3
CAMK1 58 0
CAMKK beta
3
 0
CDK2-Cyclin A
6
 1
CDK9-Cyclin T1 12 2
CHK1 77 4
CHK2 107 4
CK1 delta 100 10
CK1 gamma 2 85 14
CK2 100 2
CLK2 49 8
CSK 81 7
DAPK1 95 15
DDR2
10
 3
DYRK1A 31 1
DYRK2 103 9
DYRK3 47 2
EF2K 109 5
EIF2AK3 112 2
EPH-A2 86 7
EPH-A4 69 10
EPH-B1 110 5
EPH-B2 96 10
EPH-B3 99 4
EPH-B4 98 9
ERK1 105 10
ERK2 98 7
ERK5 57 1
ERK8
10
 1
FGF-R1 77 3
GCK 13 4
GSK3 beta 95 12
HER4 108 11
HIPK1 109 0
HIPK2 90 10
HIPK3 101 15
IGF-1R 111 8
IKK beta 100 7
IKK epsilon 87 6
IR 97 17
IRAK1 48 3
IRAK4 28 5
IRR 80 6
JAK2 66 4
JNK1 100 7
JNK2 99 4
JNK3 90 14
Lck 21 4
LKB1 72 5
MAP4K3
0
 0
MAP4K5
6
 1
MAPKAP-K2 112 4
MAPKAP-K3 120 14
MARK1 14 1
MARK2 31 0
MARK3
8
 2
MARK4 24 3
MEKK1 89 2
MELK 34 6
MINK1 17 1
MKK1 39 0
MKK2 32 2
MKK6 94 6
MLK1
2
 1
MLK3
4
 1
MNK1 35 4
MNK2 16 1
MPSK1 108 22
MSK1 60 1
MST2
5
 1
MST3 41 2
MST4 91 0
NEK2a 117 4
NEK6 93 5
NUAK1
4
 0
OSR1 109 11
p38 alpha MAPK 92 6
p38 beta MAPK 118 1
p38 delta MAPK 107 5
p38 gamma MAPK 104 1
PAK2 96 2
PAK4 61 12
PAK5 81 1
PAK6 101 11
PDGFRA
10
 1
PDK1 94 2
PHK
1
 0
PIM1 61 7
PIM2 91 4
PIM3 87 1
PINK 122 8
PKA 105 8
PKB alpha 104 12
PKB beta 120 30
PKC alpha 78 8
PKC gamma 89 5
PKC zeta 115 12
PKD1 66 2
PLK1 104 6
PRAK 98 0
PRK2
5
 1
RIPK2
10
 0
ROCK 2 36 3
RSK1 14 1
RSK2 46 4
S6K1 80 4
SGK1 80 4
SIK2
6
 3
SIK3 11 11
SmMLCK 102 8
Src 72 7
SRPK1 102 3
STK33 93 18
SYK 87 13
TAK1 41 9
TAO1 52 2
TBK1 55 7
TESK1 146 16
TGFBR1 133 15
TIE2 92 0
TLK1 108 8
TrkA
2
 0
TSSK1 46 3
TTBK1 107 4
TTBK2 107 0
TTK 75 18
ULK1 36 8
ULK2
4
 1
VEGFR1
5
 1
WNK1 109 7
YES1 26 3
ZAP70 107 5