Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Volasertib   C34H50N8O3 618.81 PLK1 Rudolph D (2009) Clin Cancer Res 15(9) 3094-3102
Grinshtein N (2011) Cancer Res 71(4) 1385-1395

1.00 83
VPS34-IN1   C21H24ClN7O 425.91 Vps34 Bago R (2014) Biochem J.

WO2012085815
1.00 87
VPS34-IN2 (PIK-III)   C17H17N7 319.36 PI3K, VPS34 William E. Dowdle (2014) Nature Cell Biology

WO2012085815
1.00 92
VPS34-IN2 (PIK-III)   C17H17N7 319.36 PI3K, VPS34 William E. Dowdle (2014) Nature Cell Biology

WO2012085815
0.10 95
Withaferin A C28H38O6 470.60 IKKβ Kaileh (2007) J.Biol.Chem. 282 4253


10.00 106
Withaferin A C28H38O6 470.60 IKKβ Kaileh (2007) J.Biol.Chem. 282 4253


1.00 110
Withaferin A C28H38O6 470.60 IKKβ Kaileh (2007) J.Biol.Chem. 282 4253


0.10 101
WNK-463   C21H24F3N7O2 463.46 WNK Yamada K (2016) Nat Chem Biol. 12(11) 896-898


1.00 111
WP1130   C19H18BrN3O 384.27 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085.
V Kapuria (2010) Cancer Res 70(22) 9265-9276

5.00 92
WP1130   C19H18BrN3O 384.27 DUB V Kapuria (2011) Cell Signal 23(12) 2076-2085.
V Kapuria (2010) Cancer Res 70(22) 9265-9276

1.00 98