Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
SU-6656   C19H21N3O3S 371.50 Src Bowman T. (2001) Proc. Natl. Acad. Sci. USA 98 7319
Blake R.A. (2000) Mol. Cell. Biol. 20 9018

10.00 36
TAE684 C30H40ClN7O3S 614.22 NPM-ALK Zhang J. (2012) Bioorg. Med. Chem. Lett. 22 1864–1869
Galkin A.V. (2007) Proc. Natl. Acad. Sci. USA 104 (1) 270-275

10.00 39
TAE684 C30H40ClN7O3S 614.22 NPM-ALK Zhang J. (2012) Bioorg. Med. Chem. Lett. 22 1864–1869
Galkin A.V. (2007) Proc. Natl. Acad. Sci. USA 104 (1) 270-275

1.00 97
Tenovin-6   C25H34N4O2S 454.60

10.00 103
Tenovin-6   C25H34N4O2S 454.60

1.00 101
TTT-3002 LRRK2 Yao C (2012) Hum Mol Genet.


 1.00 37
TTT-3002 LRRK2 Yao C (2012) Hum Mol Genet.


 0.01 98
TTT-3002 LRRK2 Yao C (2012) Hum Mol Genet.


 0.10 82
Ubiquitin E1 Inhibitor (PYR-41)   C17H13N3O7 • 3H2O 425.40 Ubiquitin-E1 Yang Y (2007) Cancer Res. 67 9472


 10.00 107
Volasertib   C34H50N8O3 618.81 PLK1 Rudolph D (2009) Clin Cancer Res 15(9) 3094-3102
Grinshtein N (2011) Cancer Res 71(4) 1385-1395

0.10 97