Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 367 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Reference 2
Lazertinib   C30H34N8O3 554.60 EGFR mutants
LDN-193189   C25H22N6 406.49 BMP Yu (2008) Nat. Chem. Biol. 4 33–41 Cuny (2008) Bioorg. Med. Chem. Lett. 18 4388–4392
Leflunomide   C12H9F3N2O2 270.21
Lenalidomide (Revlimid) C13H13N3O3 259.26 TNF-α Rushworth S.A. (2013) Cellular Signalling 25 1 106-112
Leniolisib   C21H25F3N6O2 450.50 PI3Kδ
Lenvatinib   C21H19ClN4O4 426.90 VEGFRs
LFM-A13   C11H8Br2N2O2 360.00 BTK Vassilev J.Biol.Chem. 274 1646 Mahajan et al J.Biol.Chem. 274 9587
LiCl   ClLi 42.39 GSK3b Galli C. (2013) Clin Oral Implants Res. 921-7.
Lorlatinib C21H19FN6O2 406.40 ALK /ROS
LRRK2-IN1   C31H38N8O3 570.69 LRRK2 Deng X. (2011) Nat. Chem. Biol. 7 203
LY294002   C19H17NO3 307.40 PI3K Baumann P. and West S.C. (1998) Proc. Natl. Acad. Sci. USA 95 14066 Cardone M.H. (1998) Science 282 1318
LY333531 (Ruboxistaurin)   C28H28IN4O3 .CH4O3S 582.73 PKC Jirousek M.R. (1996) J. Med. Chem. 39 2664 Tang S. (2008) Proteins 72(1) 447-60
LY364947   C17H12N4 272.31 TGF-β type-I Sawyer (2003) J.Med.Chem. 46 3953 Li (2006) J.Med.Chem. 49 2138
Margetuximab HER2
Merck 7 (PDK1)   C28H22F2N4O4 516.50 PDK1 Nagashima K. (2011) J.Biol.Chem. 286 6433-6448
Metformin   C4H11N5 129.16 AMP Ouyang J. (2010) J. Biol. Chem. 2011 Jan. 7 286(1) 1-11
Midostaurin   C35H30N4O4 570.60 PKC; FLT3
MK-2206   C25H21N5O.2HCl 480.39 PKB Hui-Fang Li (2009) Radiation Oncology 4 43
ML-7, Hydrochloride   C15H17IN2O2S • HCl 452.70 MLCK Krarup T. (1998) Am. J. Physiol. 275 C239 Saitoh M. (1987) J. Biol. Chem. 262 7796
ML-9, Hydrochloride   C15H17ClN2O2S • HCl 361.30 MLCK Reig J.A. (1993) Neurochem. Res. 18 317 Nagatsu T. (1987) Biochem. Biophys. Res. Commun. 143 1045