Inhibitor | LDN-193189  

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
ABL	43	2
AMPK	96	2
ASK1	93	6
Aurora A	100	10
Aurora B	95	3
BRK	78	1
BRSK1	88	7
BRSK2	88	4
BTK	111	5
CAMK1	86	15
CAMKK beta	43	9
CDK2-Cyclin A	84	1
CHK1	101	3
CHK2	99	5
CK1 delta	91	4
CK2	90	9
CLK2	67	3
CSK	95	11
DAPK1	89	6
DYRK1A	75	1
DYRK2	108	4
DYRK3	86	9
EF2K	95	16
EPH-A2	81	15
EPH-A4	84	6
EPH-B1	117	13
EPH-B2	108	6
EPH-B3	88	12
EPH-B4	96	6
ERK1	89	8
ERK2	89	15
ERK8	87	1
FGF-R1	69	1
GCK	37	3
GSK3 beta	81	6
HER4	88	13
HIPK1	97	1
HIPK2	93	2
HIPK3	104	5
IGF-1R	112	12
IKK beta	81	26
IKK epsilon	87	1
IR	105	5
IRAK4	88	9
IRR	82	7
JAK2	100	7
JNK1	89	7
JNK2	88	5
JNK3	98	4
Lck	81	2
LKB1	109	1
MAPKAP-K2	81	5
MAPKAP-K3	80	11
MARK1	88	9
MARK2	76	1
MARK3	78	8
MARK4	75	9
MEKK1	90	4
MELK	81	15
MINK1	74	3
MKK1	98	4
MKK2	88	6
MKK6	87	5
MLK1	104	2
MLK3	86	1
MNK1	82	6
MNK2	90	16
MPSK1	97	7
MSK1	91	4
MST2	102	7
MST4	105	0
NEK2a	118	13
NEK6	80	8
NUAK1	57	11
p38 alpha MAPK	78	13
p38 beta MAPK	89	22
p38 delta MAPK	89	0
p38 gamma MAPK	78	11
PAK2	100	3
PAK4	82	2
PAK5	95	14
PAK6	108	7
PDK1	85	6
PHK	85	12
PIM1	83	11
PIM2	98	1
PIM3	105	6
PKA	99	3
PKB alpha	102	8
PKB beta	77	3
PKC alpha	92	10
PKC gamma	99	9
PKC zeta	88	11
PKD1	93	4
PLK1	97	8
PRAK	89	2
PRK2	65	6
RIPK2	52	2
ROCK 2	98	1
RSK1	86	0
RSK2	73	8
S6K1	110	20
SGK1	62	10
SmMLCK	104	12
Src	94	20
SRPK1	95	15
STK33	81	7
SYK	82	8
TAK1	84	6
TAO1	102	1
TBK1	74	5
TIE2	102	10
TrkA	87	7
TTK	89	4
VEGFR1	48	5
YES1	73	4
ZAP70	86	5

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	6	0
AMPK	59	6
ASK1	90	9
Aurora A	91	1
Aurora B	76	7
BRK	21	0
BRSK1	85	0
BRSK2	68	7
BTK	94	1
CAMK1	85	5
CAMKK beta	13	1
CDK2-Cyclin A	84	11
CHK1	109	9
CHK2	103	2
CK1 delta	69	2
CK2	89	1
CLK2	21	1
CSK	103	5
DAPK1	91	5
DYRK1A	40	2
DYRK2	107	2
DYRK3	89	3
EF2K	96	6
EPH-A2	81	5
EPH-A4	83	3
EPH-B1	116	21
EPH-B2	80	8
EPH-B3	75	1
EPH-B4	89	8
ERK1	97	4
ERK2	89	13
ERK8	49	6
FGF-R1	20	5
GCK	11	1
GSK3 beta	83	1
HER4	76	9
HIPK1	99	3
HIPK2	91	2
HIPK3	111	23
IGF-1R	99	17
IKK beta	98	15
IKK epsilon	89	1
IR	107	2
IRAK4	91	1
IRR	68	8
JAK2	104	14
JNK1	101	0
JNK2	103	11
JNK3	97	7
Lck	40	3
LKB1	98	2
MAPKAP-K2	91	12
MAPKAP-K3	79	14
MARK1	54	0
MARK2	63	13
MARK3	34	0
MARK4	58	1
MEKK1	83	7
MELK	54	5
MINK1	15	2
MKK1	93	4
MKK2	91	6
MKK6	89	5
MLK1	70	5
MLK3	33	2
MNK1	63	8
MNK2	60	18
MPSK1	98	2
MSK1	83	8
MST2	104	4
MST4	123	16
NEK2a	119	14
NEK6	83	0
NUAK1	17	3
p38 alpha MAPK	84	2
p38 beta MAPK	104	2
p38 delta MAPK	110	8
p38 gamma MAPK	79	9
PAK2	108	20
PAK4	94	1
PAK5	82	7
PAK6	107	5
PDK1	97	8
PHK	60	5
PIM1	83	8
PIM2	104	3
PIM3	103	12
PKA	101	0
PKB alpha	103	17
PKB beta	91	4
PKC alpha	96	4
PKC gamma	97	2
PKC zeta	93	10
PKD1	83	11
PLK1	100	1
PRAK	100	1
PRK2	69	2
RIPK2	2	0
ROCK 2	86	7
RSK1	79	6
RSK2	69	5
S6K1	92	7
SGK1	79	5
SmMLCK	107	7
Src	52	1
SRPK1	116	1
STK33	44	3
SYK	80	5
TAK1	44	3
TAO1	110	1
TBK1	62	5
TIE2	86	11
TrkA	71	2
TTK	101	4
VEGFR1	48	57
YES1	21	1
ZAP70	69	3

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	4	4
AMPK	18	1
ASK1	91	10
Aurora A	56	0
Aurora B	47	1
BRK	5	0
BRSK1	57	3
BRSK2	20	4
BTK	52	3
CAMK1	45	3
CAMKK beta	8	1
CDK2-Cyclin A	34	5
CHK1	96	8
CHK2	59	1
CK1 delta	22	1
CK2	81	9
CLK2	5	1
CSK	72	6
DAPK1	72	15
DYRK1A	9	0
DYRK2	77	7
DYRK3	81	34
EF2K	79	3
EPH-A2	50	9
EPH-A4	57	10
EPH-B1	100	11
EPH-B2	37	9
EPH-B3	48	7
EPH-B4	46	2
ERK1	90	1
ERK2	107	4
ERK8	11	1
FGF-R1	8	3
GCK	3	0
GSK3 beta	62	7
HER4	56	4
HIPK1	85	6
HIPK2	56	14
HIPK3	90	1
IGF-1R	89	5
IKK beta	83	1
IKK epsilon	56	3
IR	93	4
IRAK4	53	0
IRR	37	1
JAK2	79	5
JNK1	78	2
JNK2	83	9
JNK3	94	5
Lck	7	1
LKB1	80	9
MAPKAP-K2	73	0
MAPKAP-K3	86	2
MARK1	14	3
MARK2	32	1
MARK3	11	1
MARK4	24	6
MEKK1	60	9
MELK	18	2
MINK1	4	2
MKK1	67	1
MKK2	52	9
MKK6	104	1
MLK1	60	63
MLK3	8	0
MNK1	39	8
MNK2	34	1
MPSK1	84	2
MSK1	87	7
MST2	76	2
MST4	181	8
NEK2a	79	6
NEK6	88	5
NUAK1	5	1
p38 alpha MAPK	75	4
p38 beta MAPK	96	3
p38 delta MAPK	72	3
p38 gamma MAPK	93	22
PAK2	94	0
PAK4	62	4
PAK5	72	8
PAK6	100	1
PDK1	107	3
PHK	21	1
PIM1	82	7
PIM2	92	6
PIM3	84	4
PKA	94	7
PKB alpha	81	25
PKB beta	58	3
PKC alpha	88	6
PKC gamma	92	5
PKC zeta	55	3
PKD1	33	4
PLK1	91	1
PRAK	60	9
PRK2	37	0
RIPK2	3	1
ROCK 2	85	4
RSK1	29	3
RSK2	57	4
S6K1	84	1
SGK1	70	4
SmMLCK	60	3
Src	16	3
SRPK1	79	6
STK33	11	0
SYK	36	7
TAK1	13	5
TAO1	79	11
TBK1	26	0
TIE2	30	6
TrkA	38	0
TTK	61	1
VEGFR1	0	0
YES1	7	3
ZAP70	101	9