Inhibitor | LY333531 (Ruboxistaurin)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
LY333531 (Ruboxistaurin)   C28H28IN4O3 .CH4O3S 582.73 192050-59-2 153999 PKC Jirousek M.R. (1996) J. Med. Chem. 39 2664 Tang S. (2008) Proteins 72(1) 447-60

Screening Results Chart

Screening Results Tables

Screen Conc: 0.01µM
Kinase % Activity Remaining Standard Deviation
AMPK 91 15
Aurora B 82 3
BRSK2 105 5
BTK 84 4
CAMK1 95 10
CAMKK beta 102 12
CDK2-Cyclin A 87 9
CHK1 85 1
CHK2 92 3
CK1 delta 121 19
CK2 117 1
CSK 96 2
DYRK1A 89 0
DYRK2 78 13
DYRK3 97 5
EF2K 100 17
EPH-A2 109 10
EPH-B3 96 14
ERK1 101 6
ERK2 104 3
ERK8 84 17
FGF-R1 108 16
GSK3 beta 89 9
HIPK2 95 3
IGF-1R 97 1
IKK beta 100 8
IKK epsilon 82 8
IR 110 12
IRR 79 3
JNK1 89 2
JNK2 103 2
Lck 97 2
MAPKAP-K2 102 14
MARK3 82 3
MELK 98 15
MKK1 78 0
MNK1 104 4
MNK2 86 6
MSK1 81 13
MST2 92 7
MST4 97 0
NEK2a 98 6
NEK6 87 5
p38 alpha MAPK 95 6
p38 beta MAPK 93 4
p38 delta MAPK 101 3
p38 gamma MAPK 109 4
PAK4 96 3
PAK5 119 0
PAK6 100 0
PDK1 86 8
PHK 112 7
PIM1 69 0
PIM2 110 16
PIM3 58 14
PKA 104 0
PKB alpha 101 17
PKB beta 90 10
PKC alpha 51 4
PKC zeta 95 4
PKD1 97 28
PLK1 99 11
PRAK 86 0
PRK2 98 5
ROCK 2 103 12
RSK1 80 14
RSK2 77 5
S6K1 96 15
SGK1 121 17
SmMLCK 95 12
Src 92 1
SRPK1 97 8
SYK 102 4
TBK1 83 16
VEGFR1 95 8
YES1 92 4
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
AMPK 17 4
Aurora B 65 2
Aurora C 78 5
BRSK2 67 2
BTK 82 4
CAMK1 85 1
CAMKK alpha 114 5
CAMKK beta 58 5
CDK2-Cyclin A 66 2
CHK1 63 0
CHK2 103 4
CK1 delta 100 1
CK2 89 3
CSK 78 1
DYRK1A 76 1
DYRK2 89 1
DYRK3 80 6
EF2K 90 1
EPH-A2 100 13
EPH-B3 91 9
ERK1 84 4
ERK2 93 0
ERK8 92 6
FGF-R1 103 26
GSK3 beta 42 1
HIPK2 55 0
HIPK3 77 5
IGF-1R 85 1
IKK beta 83 6
IKK epsilon 31 0
IR 101 15
IRR 69 4
JNK1 86 6
JNK2 98 0
JNK3 112 0
Lck 62 5
MAPKAP-K2 114 3
MAPKAP-K3 93 2
MARK3 68 2
MELK 58 9
MKK1 28 6
MNK1 88 0
MNK2 100 1
MSK1 49 8
MST2 34 1
MST4 70 5
NEK2a 84 4
NEK6 88 1
NEK7 107 7
p38 alpha MAPK 96 8
p38 beta MAPK 108 2
p38 delta MAPK 92 3
p38 gamma MAPK 103 4
PAK4 73 8
PAK5 80 6
PAK6 85 4
PDK1 26 1
PHK 48 6
PIM1
4
 0
PIM2 50 4
PIM3
2
 0
PKA 60 1
PKB alpha 89 7
PKB beta 82 4
PKC alpha
3
 0
PKC zeta 90 7
PKD1 90 2
PLK1 81 0
PRAK 85 9
PRK2 51 4
ROCK 2 104 3
RSK1 16 5
RSK2 12 2
S6K1 64 7
SGK1 67 7
SmMLCK 65 4
Src 93 1
SRPK1 90 1
SYK 102 7
TBK1 41 1
VEGFR1 71 0
YES1 102 13
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 48 3
Aurora B 22 1
BRSK2 65 0
BTK 71 2
CAMK1 74 0
CAMKK beta 25 1
CDK2-Cyclin A 50 1
CHK1 30 0
CHK2 46 2
CK1 delta 121 7
CK2 112 2
CSK 100 13
DYRK1A 31 3
DYRK2 47 0
DYRK3 53 3
EF2K 79 0
EPH-A2 86 6
EPH-B3 88 12
ERK1 100 7
ERK2 102 3
ERK8 22 2
FGF-R1 57 4
GSK3 beta 12 0
HIPK2 18 0
IGF-1R 42 3
IKK beta 87 1
IKK epsilon
7
 1
IR 99 9
IRR 55 14
JNK1 65 3
JNK2 89 1
Lck 72 1
MAPKAP-K2 102 7
MARK3 62 8
MELK 56 11
MKK1 26 12
MNK1 100 1
MNK2 89 23
MSK1 11 0
MST2
10
 0
MST4 29 2
NEK2a 100 7
NEK6 93 11
p38 alpha MAPK 86 2
p38 beta MAPK 113 13
p38 delta MAPK 92 20
p38 gamma MAPK 91 5
PAK4 88 1
PAK5 101 4
PAK6 88 3
PDK1 12 0
PHK 25 0
PIM1
1
 0
PIM2 30 2
PIM3
5
 1
PKA 82 0
PKB alpha 87 0
PKB beta 78 4
PKC alpha
8
 1
PKC zeta 57 1
PKD1 63 3
PLK1 98 0
PRAK 99 6
PRK2 22 1
ROCK 2 84 2
RSK1 73 5
RSK2
5
 2
S6K1 12 1
SGK1 75 14
SmMLCK 33 13
Src 89 11
SRPK1 101 2
SYK 62 2
TBK1
8
 0
VEGFR1 29 8
YES1 67 1