Inhibitor | LRRK2-IN1  

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	89	3
AMPK	70	7
ASK1	89	4
Aurora A	30	0
Aurora B	56	1
BRK	60	12
BRSK1	83	6
BRSK2	102	3
BTK	87	1
CAMK1	95	5
CAMKK beta	61	12
CDK2-Cyclin A	87	3
CHK1	82	9
CHK2	39	10
CK1 delta	91	2
CK2	71	6
CLK2	89	7
CSK	104	6
DAPK1	104	5
DYRK1A	78	8
DYRK2	106	11
DYRK3	90	8
EF2K	107	1
EIF2AK3	91	9
EPH-A2	104	3
EPH-A4	114	13
EPH-B1	91	0
EPH-B2	93	8
EPH-B3	93	14
EPH-B4	99	5
ERK1	105	0
ERK2	82	14
ERK8	111	7
FGF-R1	83	4
GCK	81	2
GSK3 beta	86	9
HER4	102	2
HIPK1	89	1
HIPK2	76	2
HIPK3	123	8
IGF-1R	87	6
IKK beta	86	5
IKK epsilon	101	1
IR	88	6
IRAK1	97	9
IRAK4	85	2
IRR	87	11
JAK2	99	10
JNK1	102	10
JNK2	91	2
JNK3	104	14
Lck	106	13
LKB1	87	8
MAPKAP-K2	86	1
MAPKAP-K3	86	4
MARK1	99	1
MARK2	85	3
MARK3	76	6
MARK4	105	7
MEKK1	122	9
MELK	100	8
MINK1	99	8
MKK1	77	3
MKK2	77	13
MKK6	98	2
MLK1	69	1
MLK3	108	5
MNK1	72	1
MNK2	94	3
MPSK1	90	1
MSK1	89	5
MST2	90	3
MST4	79	1
NEK2a	93	12
NEK6	99	3
NUAK1	77	2
OSR1	76	3
p38 alpha MAPK	87	10
p38 beta MAPK	62	4
p38 delta MAPK	104	7
p38 gamma MAPK	85	9
PAK2	88	3
PAK4	107	1
PAK5	96	1
PAK6	91	3
PDK1	91	10
PHK	93	5
PIM1	101	15
PIM2	89	3
PIM3	63	5
PKA	77	7
PKB alpha	101	10
PKB beta	101	13
PKC alpha	91	8
PKC gamma	124	2
PKC zeta	102	5
PKD1	73	7
PLK1	109	12
PRAK	103	1
PRK2	82	0
RIPK2	103	4
ROCK 2	82	14
RSK1	89	3
RSK2	84	4
S6K1	86	9
SGK1	93	2
SmMLCK	76	8
Src	99	4
SRPK1	98	4
STK33	67	0
SYK	71	5
TAK1	74	2
TAO1	92	8
TBK1	94	6
TIE2	106	9
TLK1	90	6
TrkA	83	7
TTK	87	6
VEGFR1	78	10
YES1	96	6
ZAP70	114	3

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	85	3
AMPK	67	8
ASK1	84	4
Aurora A	5	0
Aurora B	31	5
BRK	17	4
BRSK1	92	2
BRSK2	87	9
BTK	79	1
CAMK1	53	5
CAMKK beta	29	8
CDK2-Cyclin A	88	2
CHK1	67	6
CHK2	9	3
CK1 delta	87	8
CK2	84	12
CLK2	72	10
CSK	99	2
DAPK1	77	5
DYRK1A	91	7
DYRK2	99	9
DYRK3	91	6
EF2K	102	8
EIF2AK3	92	10
EPH-A2	82	12
EPH-A4	121	4
EPH-B1	104	4
EPH-B2	113	4
EPH-B3	91	8
EPH-B4	118	0
ERK1	101	5
ERK2	85	1
ERK8	92	8
FGF-R1	52	12
GCK	70	11
GSK3 beta	86	1
HER4	91	6
HIPK1	90	15
HIPK2	70	8
HIPK3	98	14
IGF-1R	86	7
IKK beta	82	4
IKK epsilon	106	14
IR	65	11
IRAK1	97	4
IRAK4	90	2
IRR	78	9
JAK2	80	8
JNK1	81	6
JNK2	87	8
JNK3	73	3
Lck	85	12
LKB1	77	4
MAPKAP-K2	90	12
MAPKAP-K3	79	6
MARK1	91	8
MARK2	83	1
MARK3	82	6
MARK4	89	9
MEKK1	98	3
MELK	92	4
MINK1	108	7
MKK1	81	3
MKK2	79	13
MKK6	91	3
MLK1	75	8
MLK3	110	13
MNK1	53	0
MNK2	44	6
MPSK1	104	7
MSK1	89	8
MST2	80	3
MST4	83	5
NEK2a	95	3
NEK6	90	1
NUAK1	31	4
OSR1	32	5
p38 alpha MAPK	85	2
p38 beta MAPK	30	1
p38 delta MAPK	107	6
p38 gamma MAPK	76	4
PAK2	89	2
PAK4	98	9
PAK5	83	10
PAK6	88	6
PDK1	98	0
PHK	54	6
PIM1	82	8
PIM2	97	5
PIM3	60	5
PKA	93	3
PKB alpha	99	2
PKB beta	90	9
PKC alpha	99	7
PKC gamma	118	13
PKC zeta	112	14
PKD1	50	1
PLK1	58	11
PRAK	93	2
PRK2	86	9
RIPK2	81	5
ROCK 2	85	11
RSK1	93	9
RSK2	86	5
S6K1	74	3
SGK1	85	5
SmMLCK	35	6
Src	116	3
SRPK1	94	2
STK33	26	0
SYK	85	13
TAK1	72	13
TAO1	70	6
TBK1	105	1
TIE2	104	0
TLK1	84	3
TrkA	89	15
TTK	73	6
VEGFR1	89	9
YES1	67	7
ZAP70	110	8