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Inhibitor |
Leflunomide
| Compound name |
Brutto |
MW |
CAS |
PubChem CID |
Action |
Reference |
Reference |
|
Leflunomide
|
C12H9F3N2O2
|
270.21
|
75706-12-6
|
3899
|
|
|
|
Screening Results Tables
Screen Conc:
1.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
ABL
|
101
|
1
|
|
AMPK
|
96
|
4
|
|
AMPK (hum)
|
109
|
7
|
|
ASK1
|
104
|
4
|
|
Aurora A
|
91
|
0
|
|
Aurora B
|
101
|
9
|
|
BRK
|
78
|
7
|
|
BRSK1
|
89
|
6
|
|
BRSK2
|
95
|
1
|
|
BTK
|
125
|
8
|
|
CAMK1
|
100
|
8
|
|
CAMKK beta
|
88
|
4
|
|
CDK2-Cyclin A
|
112
|
2
|
|
CDK9-Cyclin T1
|
101
|
0
|
|
CHK1
|
104
|
1
|
|
CHK2
|
105
|
11
|
|
CK1 delta
|
91
|
1
|
|
CK1 gamma 2
|
113
|
17
|
|
CK2
|
107
|
0
|
|
CLK2
|
105
|
16
|
|
CSK
|
98
|
2
|
|
DAPK1
|
83
|
7
|
|
DDR2
|
107
|
3
|
|
DYRK1A
|
94
|
8
|
|
DYRK2
|
99
|
9
|
|
DYRK3
|
103
|
17
|
|
EF2K
|
124
|
13
|
|
EIF2AK3
|
108
|
7
|
|
EPH-A2
|
105
|
8
|
|
EPH-A4
|
114
|
19
|
|
EPH-B1
|
127
|
12
|
|
EPH-B2
|
116
|
8
|
|
EPH-B3
|
109
|
3
|
|
EPH-B4
|
115
|
16
|
|
ERK1
|
102
|
2
|
|
ERK2
|
94
|
15
|
|
ERK5
|
102
|
11
|
|
ERK8
|
85
|
12
|
|
FGF-R1
|
127
|
2
|
|
GCK
|
106
|
1
|
|
GSK3 beta
|
116
|
5
|
|
HER4
|
129
|
3
|
|
HIPK1
|
117
|
1
|
|
HIPK2
|
118
|
2
|
|
HIPK3
|
85
|
4
|
|
IGF-1R
|
113
|
20
|
|
IKK beta
|
105
|
17
|
|
IKK epsilon
|
132
|
2
|
|
IR
|
89
|
2
|
|
IRAK1
|
99
|
13
|
|
IRAK4
|
93
|
10
|
|
IRR
|
97
|
4
|
|
JAK2
|
107
|
26
|
|
JNK1
|
88
|
2
|
|
JNK2
|
108
|
10
|
|
JNK3
|
96
|
7
|
|
Lck
|
121
|
14
|
|
LKB1
|
94
|
15
|
|
MAP4K3
|
101
|
6
|
|
MAP4K5
|
126
|
30
|
|
MAPKAP-K2
|
87
|
3
|
|
MAPKAP-K3
|
98
|
3
|
|
MARK1
|
109
|
35
|
|
MARK2
|
104
|
3
|
|
MARK3
|
122
|
5
|
|
MARK4
|
105
|
2
|
|
MEKK1
|
109
|
7
|
|
MELK
|
100
|
6
|
|
MINK1
|
121
|
14
|
|
MKK1
|
103
|
3
|
|
MKK2
|
101
|
5
|
|
MKK6
|
92
|
7
|
|
MLK1
|
108
|
7
|
|
MLK3
|
91
|
6
|
|
MNK1
|
100
|
11
|
|
MNK2
|
106
|
11
|
|
MPSK1
|
98
|
9
|
|
MSK1
|
92
|
8
|
|
MST2
|
134
|
5
|
|
MST3
|
95
|
7
|
|
MST4
|
119
|
6
|
|
NEK2a
|
102
|
7
|
|
NEK6
|
108
|
12
|
|
NUAK1
|
103
|
5
|
|
OSR1
|
119
|
24
|
|
p38 alpha MAPK
|
106
|
11
|
|
p38 beta MAPK
|
106
|
19
|
|
p38 delta MAPK
|
95
|
7
|
|
p38 gamma MAPK
|
108
|
4
|
|
PAK2
|
105
|
15
|
|
PAK4
|
99
|
11
|
|
PAK5
|
89
|
6
|
|
PAK6
|
104
|
1
|
|
PDGFRA
|
105
|
18
|
|
PDK1
|
91
|
3
|
|
PHK
|
87
|
9
|
|
PIM1
|
91
|
5
|
|
PIM2
|
92
|
21
|
|
PIM3
|
102
|
2
|
|
PINK
|
102
|
30
|
|
PKA
|
97
|
0
|
|
PKB alpha
|
102
|
3
|
|
PKB beta
|
126
|
7
|
|
PKC alpha
|
98
|
3
|
|
PKC gamma
|
107
|
3
|
|
PKC zeta
|
101
|
1
|
|
PKD1
|
122
|
11
|
|
PLK1
|
103
|
2
|
|
PRAK
|
80
|
13
|
|
PRK2
|
108
|
4
|
|
RIPK2
|
95
|
2
|
|
ROCK 2
|
105
|
7
|
|
RSK1
|
114
|
2
|
|
RSK2
|
115
|
13
|
|
S6K1
|
95
|
2
|
|
SGK1
|
104
|
3
|
|
SIK2
|
102
|
8
|
|
SIK3
|
99
|
10
|
|
SmMLCK
|
118
|
6
|
|
Src
|
135
|
9
|
|
SRPK1
|
110
|
10
|
|
STK33
|
106
|
17
|
|
SYK
|
108
|
0
|
|
TAK1
|
115
|
8
|
|
TAO1
|
106
|
6
|
|
TBK1
|
100
|
4
|
|
TESK1
|
116
|
22
|
|
TGFBR1
|
111
|
10
|
|
TIE2
|
96
|
4
|
|
TLK1
|
94
|
1
|
|
TrkA
|
98
|
9
|
|
TSSK1
|
97
|
2
|
|
TTBK1
|
98
|
1
|
|
TTBK2
|
110
|
0
|
|
TTK
|
98
|
2
|
|
ULK1
|
122
|
25
|
|
ULK2
|
102
|
8
|
|
VEGFR1
|
99
|
18
|
|
WNK1
|
102
|
7
|
|
YES1
|
91
|
3
|
|
ZAP70
|
115
|
5
|
Screen Conc:
10.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
ABL
|
103
|
3
|
|
AMPK
|
104
|
2
|
|
AMPK (hum)
|
103
|
14
|
|
ASK1
|
100
|
5
|
|
Aurora A
|
100
|
6
|
|
Aurora B
|
113
|
6
|
|
BRK
|
82
|
12
|
|
BRSK1
|
104
|
6
|
|
BRSK2
|
100
|
5
|
|
BTK
|
132
|
15
|
|
CAMK1
|
102
|
2
|
|
CAMKK beta
|
91
|
6
|
|
CDK2-Cyclin A
|
96
|
2
|
|
CDK9-Cyclin T1
|
109
|
1
|
|
CHK1
|
101
|
8
|
|
CHK2
|
108
|
11
|
|
CK1 delta
|
99
|
5
|
|
CK1 gamma 2
|
94
|
10
|
|
CK2
|
105
|
1
|
|
CLK2
|
100
|
9
|
|
CSK
|
104
|
1
|
|
DAPK1
|
83
|
12
|
|
DDR2
|
116
|
1
|
|
DYRK1A
|
106
|
0
|
|
DYRK2
|
99
|
2
|
|
DYRK3
|
103
|
2
|
|
EF2K
|
124
|
8
|
|
EIF2AK3
|
110
|
13
|
|
EPH-A2
|
99
|
3
|
|
EPH-A4
|
99
|
6
|
|
EPH-B1
|
124
|
5
|
|
EPH-B2
|
118
|
34
|
|
EPH-B3
|
117
|
11
|
|
EPH-B4
|
121
|
14
|
|
ERK1
|
103
|
1
|
|
ERK2
|
122
|
26
|
|
ERK5
|
94
|
0
|
|
ERK8
|
90
|
7
|
|
FGF-R1
|
117
|
6
|
|
GCK
|
114
|
23
|
|
GSK3 beta
|
128
|
19
|
|
HER4
|
104
|
1
|
|
HIPK1
|
101
|
3
|
|
HIPK2
|
109
|
10
|
|
HIPK3
|
110
|
1
|
|
IGF-1R
|
130
|
21
|
|
IKK beta
|
92
|
8
|
|
IKK epsilon
|
122
|
5
|
|
IR
|
109
|
21
|
|
IRAK1
|
100
|
10
|
|
IRAK4
|
84
|
4
|
|
IRR
|
97
|
9
|
|
JAK2
|
117
|
3
|
|
JNK1
|
93
|
3
|
|
JNK2
|
120
|
12
|
|
JNK3
|
105
|
9
|
|
Lck
|
119
|
1
|
|
LKB1
|
107
|
10
|
|
MAP4K3
|
138
|
20
|
|
MAP4K5
|
114
|
9
|
|
MAPKAP-K2
|
92
|
0
|
|
MAPKAP-K3
|
94
|
12
|
|
MARK1
|
123
|
0
|
|
MARK2
|
105
|
22
|
|
MARK3
|
112
|
7
|
|
MARK4
|
95
|
3
|
|
MEKK1
|
119
|
5
|
|
MELK
|
94
|
7
|
|
MINK1
|
143
|
7
|
|
MKK1
|
109
|
14
|
|
MKK2
|
107
|
7
|
|
MKK6
|
99
|
6
|
|
MLK1
|
110
|
2
|
|
MLK3
|
92
|
1
|
|
MNK1
|
98
|
10
|
|
MNK2
|
109
|
13
|
|
MPSK1
|
103
|
8
|
|
MSK1
|
98
|
5
|
|
MST2
|
134
|
4
|
|
MST3
|
128
|
14
|
|
MST4
|
108
|
1
|
|
NEK2a
|
108
|
4
|
|
NEK6
|
111
|
4
|
|
NUAK1
|
101
|
3
|
|
OSR1
|
110
|
7
|
|
p38 alpha MAPK
|
107
|
17
|
|
p38 beta MAPK
|
113
|
10
|
|
p38 delta MAPK
|
93
|
13
|
|
p38 gamma MAPK
|
99
|
5
|
|
PAK2
|
104
|
5
|
|
PAK4
|
108
|
6
|
|
PAK5
|
96
|
7
|
|
PAK6
|
91
|
13
|
|
PDGFRA
|
114
|
7
|
|
PDK1
|
105
|
6
|
|
PHK
|
93
|
5
|
|
PIM1
|
101
|
8
|
|
PIM2
|
90
|
16
|
|
PIM3
|
90
|
9
|
|
PINK
|
87
|
1
|
|
PKA
|
89
|
4
|
|
PKB alpha
|
103
|
2
|
|
PKB beta
|
114
|
4
|
|
PKC alpha
|
105
|
14
|
|
PKC gamma
|
98
|
12
|
|
PKC zeta
|
119
|
13
|
|
PKD1
|
139
|
24
|
|
PLK1
|
98
|
9
|
|
PRAK
|
73
|
2
|
|
PRK2
|
105
|
13
|
|
RIPK2
|
90
|
5
|
|
ROCK 2
|
90
|
8
|
|
RSK1
|
114
|
4
|
|
RSK2
|
94
|
5
|
|
S6K1
|
98
|
1
|
|
SGK1
|
106
|
3
|
|
SIK2
|
114
|
9
|
|
SIK3
|
105
|
10
|
|
SmMLCK
|
132
|
13
|
|
Src
|
74
|
13
|
|
SRPK1
|
105
|
13
|
|
STK33
|
104
|
11
|
|
SYK
|
112
|
2
|
|
TAK1
|
115
|
12
|
|
TAO1
|
103
|
31
|
|
TBK1
|
99
|
8
|
|
TESK1
|
110
|
24
|
|
TGFBR1
|
99
|
9
|
|
TIE2
|
96
|
18
|
|
TLK1
|
107
|
11
|
|
TrkA
|
87
|
4
|
|
TSSK1
|
99
|
6
|
|
TTBK1
|
104
|
24
|
|
TTBK2
|
93
|
3
|
|
TTK
|
104
|
0
|
|
ULK1
|
122
|
11
|
|
ULK2
|
105
|
7
|
|
VEGFR1
|
93
|
13
|
|
WNK1
|
98
|
9
|
|
YES1
|
112
|
27
|
|
ZAP70
|
112
|
22
|
