Inhibitor | MK-2206  

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	98	11
ASK1	97	0
Aurora A	114	10
Aurora B	106	7
BRSK1	115	8
BRSK2	102	3
BTK	87	7
CAMK1	108	11
CAMKK beta	92	5
CDK2-Cyclin A	100	7
CHK1	96	11
CHK2	122	8
CK1 delta	119	1
CK2	104	6
CLK2	103	11
CSK	92	5
DAPK1	85	7
DYRK1A	95	0
DYRK2	96	2
DYRK3	98	2
EF2K	101	12
EPH-A2	86	5
EPH-A4	107	2
EPH-B1	96	5
EPH-B2	107	11
EPH-B3	112	13
EPH-B4	101	5
ERK1	108	6
ERK2	104	12
ERK8	106	12
FGF-R1	100	12
GCK	108	2
GSK3 beta	104	6
HER4	111	3
HIPK1	91	8
HIPK2	102	10
HIPK3	117	10
IGF-1R	116	8
IKK beta	112	5
IKK epsilon	88	7
IR	93	5
IRAK4	106	1
IRR	95	2
JAK2	81	2
JNK1	100	8
JNK2	83	6
JNK3	93	15
Lck	106	2
LKB1	102	4
MAPKAP-K2	99	9
MAPKAP-K3	88	3
MARK1	113	0
MARK2	102	2
MARK3	85	0
MARK4	98	6
MEKK1	114	3
MELK	80	8
MINK1	106	9
MKK1	83	6
MKK2	103	12
MKK6	109	2
MLK1	110	2
MLK3	103	5
MNK1	105	12
MNK2	90	10
MSK1	84	12
MST2	79	0
MST4	95	6
NEK2a	95	10
NEK6	106	10
NUAK1	101	4
p38 alpha MAPK	110	5
p38 beta MAPK	99	11
p38 delta MAPK	100	12
p38 gamma MAPK	94	7
PAK2	98	1
PAK4	75	5
PAK5	101	0
PAK6	85	5
PDK1	97	2
PHK	109	4
PIM1	102	7
PIM2	86	5
PIM3	89	7
PKA	104	7
PKB alpha	103	8
PKB beta	69	15
PKC alpha	97	3
PKC zeta	97	7
PKD1	92	2
PLK1	97	6
PRAK	81	7
PRK2	95	13
RIPK2	101	10
ROCK 2	85	10
RSK1	101	9
RSK2	91	3
S6K1	84	2
SGK1	90	5
SmMLCK	87	9
Src	101	5
SRPK1	107	2
SYK	116	6
TAK1	81	14
TAO1	104	9
TBK1	88	4
TrkA	107	9
TTK	106	7
VEGFR1	88	0
YES1	102	4

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	85	5
ASK1	87	4
Aurora A	89	9
Aurora B	88	6
BRSK1	112	1
BRSK2	88	1
BTK	96	6
CAMK1	87	3
CAMKK beta	99	8
CDK2-Cyclin A	84	11
CHK1	78	5
CHK2	81	8
CK1 delta	100	5
CK2	92	1
CLK2	81	5
CSK	91	5
DAPK1	90	12
DYRK1A	88	1
DYRK2	96	3
DYRK3	89	3
EF2K	104	0
EPH-A2	95	6
EPH-A4	116	9
EPH-B1	109	1
EPH-B2	93	2
EPH-B3	99	2
EPH-B4	105	5
ERK1	87	8
ERK2	96	11
ERK8	89	6
FGF-R1	95	12
GCK	97	3
GSK3 beta	85	13
HER4	95	2
HIPK1	85	6
HIPK2	97	11
HIPK3	100	8
IGF-1R	85	13
IKK beta	98	5
IKK epsilon	90	12
IR	79	6
IRAK4	92	4
IRR	80	2
JAK2	84	10
JNK1	100	3
JNK2	94	1
JNK3	91	1
Lck	112	0
LKB1	85	0
MAPKAP-K2	110	8
MAPKAP-K3	107	9
MARK1	88	4
MARK2	97	1
MARK3	99	1
MARK4	102	6
MEKK1	101	5
MELK	75	4
MINK1	86	4
MKK1	72	2
MKK2	99	12
MKK6	98	4
MLK1	93	8
MLK3	97	6
MNK1	104	5
MNK2	100	1
MSK1	90	2
MST2	97	5
MST4	103	1
NEK2a	87	2
NEK6	98	0
NUAK1	102	13
p38 alpha MAPK	97	9
p38 beta MAPK	77	1
p38 delta MAPK	90	10
p38 gamma MAPK	94	4
PAK2	94	3
PAK4	78	4
PAK5	96	15
PAK6	100	14
PDK1	107	1
PHK	98	4
PIM1	93	11
PIM2	105	10
PIM3	83	5
PKA	91	0
PKB alpha	96	0
PKB beta	86	2
PKC alpha	94	0
PKC zeta	105	0
PKD1	92	6
PLK1	105	6
PRAK	96	4
PRK2	96	8
RIPK2	84	14
ROCK 2	87	7
RSK1	87	3
RSK2	90	10
S6K1	84	9
SGK1	85	1
SmMLCK	85	4
Src	89	3
SRPK1	106	3
SYK	100	6
TAK1	107	6
TAO1	90	3
TBK1	102	1
TrkA	90	4
TTK	105	3
VEGFR1	81	6
YES1	99	3

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	83	10
ASK1	90	4
Aurora A	93	13
Aurora B	78	4
BRSK1	87	8
BRSK2	94	5
BTK	99	4
CAMK1	35	5
CAMKK beta	84	5
CDK2-Cyclin A	75	1
CHK1	45	6
CHK2	39	0
CK1 delta	91	2
CK2	84	1
CLK2	67	8
CSK	85	4
DAPK1	48	6
DYRK1A	57	5
DYRK2	87	0
DYRK3	81	0
EF2K	109	12
EPH-A2	87	14
EPH-A4	97	5
EPH-B1	100	12
EPH-B2	74	8
EPH-B3	105	7
EPH-B4	86	6
ERK1	93	4
ERK2	75	10
ERK8	93	1
FGF-R1	70	3
GCK	85	4
GSK3 beta	72	11
HER4	97	7
HIPK1	97	13
HIPK2	80	7
HIPK3	100	8
IGF-1R	55	3
IKK beta	89	2
IKK epsilon	91	6
IR	83	12
IRAK4	99	5
IRR	61	0
JAK2	94	0
JNK1	87	6
JNK2	97	6
JNK3	84	2
Lck	80	3
LKB1	86	3
MAPKAP-K2	88	2
MAPKAP-K3	94	5
MARK1	98	4
MARK2	94	8
MARK3	91	5
MARK4	92	3
MEKK1	83	2
MELK	80	5
MINK1	69	3
MKK1	90	5
MKK2	90	7
MKK6	104	9
MLK1	66	5
MLK3	81	2
MNK1	58	6
MNK2	92	10
MSK1	76	9
MST2	94	12
MST4	105	0
NEK2a	87	4
NEK6	90	1
NUAK1	95	6
p38 alpha MAPK	101	1
p38 beta MAPK	76	0
p38 delta MAPK	106	6
p38 gamma MAPK	101	3
PAK2	103	2
PAK4	66	6
PAK5	75	4
PAK6	91	2
PDK1	105	5
PHK	68	5
PIM1	68	0
PIM2	97	5
PIM3	51	8
PKA	90	7
PKB alpha	75	3
PKB beta	68	3
PKC alpha	98	12
PKC zeta	97	4
PKD1	104	2
PLK1	94	4
PRAK	102	0
PRK2	92	0
RIPK2	38	4
ROCK 2	91	12
RSK1	62	5
RSK2	81	0
S6K1	84	0
SGK1	63	4
SmMLCK	72	3
Src	105	13
SRPK1	116	5
SYK	96	14
TAK1	49	4
TAO1	85	2
TBK1	89	13
TrkA	87	5
TTK	80	8
VEGFR1	53	1
YES1	68	6