Inhibitor | LFM-A13  

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	99	3
BRSK2	63	7
BTK	103	0
CAMK1	70	6
CAMKK beta	80	6
CDK2-Cyclin A	83	0
CHK1	68	2
CHK2	98	3
CK1 delta	97	4
CK2	68	14
CSK	77	3
DYRK1A	83	3
DYRK2	78	3
DYRK3	74	2
EF2K	97	2
EPH-A2	88	4
EPH-B3	94	13
ERK1	87	2
ERK2	94	0
ERK8	86	7
FGF-R1	89	4
GSK3 beta	78	14
HIPK2	88	7
IGF-1R	47	5
IKK beta	98	3
IKK epsilon	85	3
IR	94	28
IRR	80	5
JNK1	100	0
JNK2	98	3
Lck	95	5
MAPKAP-K2	77	1
MARK3	84	20
MELK	63	3
MKK1	55	15
MNK1	91	6
MNK2	83	9
MSK1	71	6
MST2	81	4
MST4	112	22
NEK2a	108	13
NEK6	72	0
p38 alpha MAPK	88	1
p38 beta MAPK	90	11
p38 delta MAPK	88	4
p38 gamma MAPK	99	5
PAK4	83	3
PAK5	83	8
PAK6	83	6
PDK1	81	14
PHK	103	2
PIM1	58	12
PIM2	83	2
PIM3	60	4
PKA	92	1
PKB alpha	101	4
PKB beta	110	27
PKC alpha	84	4
PKC zeta	86	2
PKD1	92	15
PLK1	100	4
PRAK	70	0
PRK2	91	2
ROCK 2	89	7
RSK1	93	4
RSK2	80	6
S6K1	86	3
SGK1	79	9
SmMLCK	86	4
Src	78	2
SRPK1	86	17
SYK	90	1
TBK1	84	1
VEGFR1	120	8
YES1	102	3

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	105	6
AMPK	84	7
ASK1	107	5
Aurora A	104	11
Aurora B	98	0
BRK	58	38
BRSK1	84	9
BRSK2	76	5
BTK	56	8
CAMK1	111	14
CAMKK beta	69	5
CDK2-Cyclin A	94	6
CHK1	87	6
CHK2	75	1
CK1 delta	98	7
CK2	45	1
CLK2	47	1
CSK	100	1
DAPK1	54	11
DYRK1A	85	7
DYRK2	34	4
DYRK3	56	5
EF2K	99	7
EIF2AK3	94	5
EPH-A2	95	8
EPH-A4	90	3
EPH-B1	91	1
EPH-B2	92	13
EPH-B3	110	7
EPH-B4	108	6
ERK1	94	7
ERK2	79	1
ERK8	85	6
FGF-R1	92	8
GCK	83	3
GSK3 beta	29	1
HER4	93	3
HIPK1	92	17
HIPK2	31	1
HIPK3	90	3
IGF-1R	90	10
IKK beta	92	15
IKK epsilon	106	5
IR	72	10
IRAK1	63	1
IRAK4	68	3
IRR	94	3
JAK2	99	4
JNK1	76	1
JNK2	76	9
JNK3	73	2
Lck	91	5
LKB1	72	6
MAPKAP-K2	78	2
MAPKAP-K3	83	7
MARK1	83	2
MARK2	98	28
MARK3	110	3
MARK4	105	14
MEKK1	100	19
MELK	45	3
MINK1	92	1
MKK1	67	4
MKK2	48	2
MKK6	98	13
MLK1	74	8
MLK3	74	19
MNK1	106	4
MNK2	89	3
MPSK1	73	16
MSK1	47	11
MST2	71	6
MST4	95	11
NEK2a	88	7
NEK6	91	14
NUAK1	69	9
OSR1	106	11
p38 alpha MAPK	95	1
p38 beta MAPK	96	2
p38 delta MAPK	97	5
p38 gamma MAPK	94	3
PAK2	84	12
PAK4	76	6
PAK5	82	2
PAK6	105	0
PDK1	99	15
PHK	77	10
PIM1	18	0
PIM2	70	8
PIM3	10	3
PKA	85	4
PKB alpha	102	10
PKB beta	67	11
PKC alpha	103	3
PKC gamma	86	1
PKC zeta	96	0
PKD1	108	13
PLK1	120	21
PRAK	98	5
PRK2	74	5
RIPK2	92	4
ROCK 2	68	4
RSK1	78	5
RSK2	76	9
S6K1	90	13
SGK1	100	4
SmMLCK	84	2
Src	104	6
SRPK1	82	0
STK33	64	1
SYK	102	9
TAK1	95	11
TAO1	123	20
TBK1	71	0
TIE2	119	4
TLK1	104	11
TrkA	69	1
TTK	69	4
VEGFR1	75	1
YES1	101	1
ZAP70	108	12

Screen Conc: 100.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	110	31
AMPK	65	5
ASK1	59	0
Aurora A	47	2
Aurora B	162	28
BRK	43	2
BRSK1	56	2
BRSK2	44	6
BTK	23	3
CAMK1	85	5
CAMKK beta	57	7
CDK2-Cyclin A	60	1
CHK1	207	9
CHK2	24	4
CK1 delta	49	10
CK2	9	1
CLK2	10	1
CSK	85	14
DAPK1	12	0
DYRK1A	44	4
DYRK2	7	1
DYRK3	10	0
EF2K	87	9
EIF2AK3	53	2
EPH-A2	61	2
EPH-A4	73	8
EPH-B1	76	1
EPH-B2	63	5
EPH-B3	83	6
EPH-B4	89	15
ERK1	100	11
ERK2	64	2
ERK8	19	0
FGF-R1	74	14
GCK	46	2
GSK3 beta	7	1
HER4	47	5
HIPK1	34	2
HIPK2	7	2
HIPK3	50	16
IGF-1R	46	6
IKK beta	90	4
IKK epsilon	86	7
IR	42	4
IRAK1	30	1
IRAK4	23	2
IRR	48	7
JAK2	48	4
JNK1	60	14
JNK2	57	4
JNK3	41	3
Lck	105	2
LKB1	58	12
MAPKAP-K2	70	0
MAPKAP-K3	53	16
MARK1	55	6
MARK2	87	9
MARK3	67	5
MARK4	48	12
MEKK1	77	3
MELK	77	3
MINK1	72	3
MKK1	34	1
MKK2	22	6
MKK6	110	23
MLK1	28	2
MLK3	29	3
MNK1	75	3
MNK2	37	9
MPSK1	82	11
MSK1	27	10
MST2	55	5
MST4	45	1
NEK2a	114	4
NEK6	96	7
NUAK1	52	3
OSR1	77	4
p38 alpha MAPK	109	2
p38 beta MAPK	75	8
p38 delta MAPK	95	7
p38 gamma MAPK	81	0
PAK2	68	2
PAK4	37	2
PAK5	79	10
PAK6	110	12
PDK1	60	0
PHK	49	3
PIM1	3	0
PIM2	18	1
PIM3	3	0
PKA	66	11
PKB alpha	78	6
PKB beta	59	7
PKC alpha	94	11
PKC gamma	104	13
PKC zeta	71	10
PKD1	58	9
PLK1	71	0
PRAK	63	13
PRK2	23	4
RIPK2	80	4
ROCK 2	21	1
RSK1	37	7
RSK2	63	1
S6K1	28	0
SGK1	53	4
SmMLCK	39	1
Src	72	3
SRPK1	74	0
STK33	34	0
SYK	64	4
TAK1	69	1
TAO1	72	3
TBK1	64	13
TIE2	77	4
TLK1	106	5
TrkA	27	6
TTK	40	2
VEGFR1	29	6
YES1	92	10
ZAP70	113	1