Inhibitor |
Merck 7 (PDK1)
Screen Conc:
0.10µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
ABL
|
106
|
0
|
|
AMPK
|
97
|
9
|
|
ASK1
|
110
|
6
|
|
Aurora A
|
110
|
6
|
|
Aurora B
|
105
|
16
|
|
BRK
|
120
|
15
|
|
BRSK1
|
118
|
1
|
|
BRSK2
|
118
|
18
|
|
BTK
|
109
|
1
|
|
CAMK1
|
95
|
9
|
|
CAMKK beta
|
119
|
30
|
|
CDK2-Cyclin A
|
90
|
1
|
|
CHK1
|
96
|
4
|
|
CHK2
|
102
|
10
|
|
CK1 delta
|
103
|
9
|
|
CK2
|
111
|
1
|
|
CLK2
|
106
|
6
|
|
CSK
|
109
|
13
|
|
DAPK1
|
106
|
18
|
|
DYRK1A
|
113
|
4
|
|
DYRK2
|
110
|
1
|
|
DYRK3
|
109
|
9
|
|
EF2K
|
95
|
11
|
|
EIF2AK3
|
107
|
9
|
|
EPH-A2
|
94
|
29
|
|
EPH-A4
|
95
|
2
|
|
EPH-B1
|
87
|
0
|
|
EPH-B2
|
118
|
2
|
|
EPH-B3
|
114
|
1
|
|
EPH-B4
|
95
|
24
|
|
ERK1
|
93
|
5
|
|
ERK2
|
102
|
1
|
|
ERK8
|
92
|
1
|
|
FGF-R1
|
96
|
5
|
|
GCK
|
102
|
7
|
|
GSK3 beta
|
97
|
8
|
|
HER4
|
102
|
7
|
|
HIPK1
|
99
|
4
|
|
HIPK2
|
92
|
11
|
|
HIPK3
|
99
|
0
|
|
IGF-1R
|
105
|
4
|
|
IKK beta
|
102
|
0
|
|
IKK epsilon
|
103
|
11
|
|
IR
|
99
|
4
|
|
IRAK1
|
117
|
8
|
|
IRAK4
|
110
|
7
|
|
IRR
|
101
|
4
|
|
JAK2
|
98
|
1
|
|
JNK1
|
100
|
10
|
|
JNK2
|
93
|
9
|
|
JNK3
|
101
|
4
|
|
Lck
|
109
|
9
|
|
LKB1
|
102
|
3
|
|
MAPKAP-K2
|
99
|
9
|
|
MAPKAP-K3
|
116
|
1
|
|
MARK1
|
111
|
20
|
|
MARK2
|
105
|
5
|
|
MARK3
|
99
|
12
|
|
MARK4
|
150
|
3
|
|
MEKK1
|
110
|
12
|
|
MELK
|
97
|
17
|
|
MINK1
|
92
|
1
|
|
MKK1
|
100
|
16
|
|
MKK2
|
121
|
13
|
|
MKK6
|
94
|
6
|
|
MLK1
|
119
|
16
|
|
MLK3
|
104
|
16
|
|
MNK1
|
106
|
8
|
|
MNK2
|
117
|
11
|
|
MPSK1
|
101
|
9
|
|
MSK1
|
101
|
5
|
|
MST2
|
102
|
7
|
|
MST4
|
101
|
2
|
|
NEK2a
|
107
|
3
|
|
NEK6
|
104
|
2
|
|
NUAK1
|
115
|
12
|
|
OSR1
|
97
|
5
|
|
p38 alpha MAPK
|
114
|
7
|
|
p38 beta MAPK
|
100
|
1
|
|
p38 delta MAPK
|
91
|
12
|
|
p38 gamma MAPK
|
98
|
1
|
|
PAK2
|
113
|
11
|
|
PAK4
|
102
|
14
|
|
PAK5
|
104
|
5
|
|
PAK6
|
102
|
2
|
|
PDK1
|
90
|
10
|
|
PHK
|
100
|
4
|
|
PIM1
|
101
|
4
|
|
PIM2
|
107
|
6
|
|
PIM3
|
103
|
4
|
|
PKA
|
105
|
1
|
|
PKB alpha
|
96
|
4
|
|
PKB beta
|
98
|
4
|
|
PKC alpha
|
99
|
5
|
|
PKC gamma
|
91
|
0
|
|
PKC zeta
|
104
|
5
|
|
PKD1
|
90
|
10
|
|
PLK1
|
118
|
14
|
|
PRAK
|
108
|
11
|
|
PRK2
|
108
|
3
|
|
RIPK2
|
102
|
2
|
|
ROCK 2
|
105
|
8
|
|
RSK1
|
95
|
17
|
|
RSK2
|
102
|
5
|
|
S6K1
|
103
|
1
|
|
SGK1
|
106
|
2
|
|
SmMLCK
|
97
|
2
|
|
Src
|
103
|
13
|
|
SRPK1
|
107
|
1
|
|
STK33
|
92
|
13
|
|
SYK
|
99
|
10
|
|
TAK1
|
97
|
8
|
|
TAO1
|
111
|
6
|
|
TBK1
|
109
|
16
|
|
TESK1
|
98
|
11
|
|
TIE2
|
104
|
4
|
|
TLK1
|
97
|
2
|
|
TrkA
|
113
|
2
|
|
TSSK1
|
93
|
4
|
|
TTBK1
|
101
|
10
|
|
TTK
|
99
|
0
|
|
VEGFR1
|
106
|
2
|
|
YES1
|
104
|
12
|
|
ZAP70
|
102
|
1
|
Screen Conc:
1.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
ABL
|
105
|
4
|
|
AMPK
|
99
|
7
|
|
ASK1
|
105
|
15
|
|
Aurora A
|
110
|
1
|
|
Aurora B
|
104
|
9
|
|
BRK
|
129
|
10
|
|
BRSK1
|
102
|
13
|
|
BRSK2
|
90
|
4
|
|
BTK
|
108
|
1
|
|
CAMK1
|
92
|
1
|
|
CAMKK beta
|
104
|
8
|
|
CDK2-Cyclin A
|
91
|
6
|
|
CHK1
|
94
|
0
|
|
CHK2
|
106
|
7
|
|
CK1 delta
|
110
|
8
|
|
CK2
|
103
|
12
|
|
CLK2
|
95
|
18
|
|
CSK
|
98
|
6
|
|
DAPK1
|
113
|
4
|
|
DYRK1A
|
97
|
8
|
|
DYRK2
|
101
|
5
|
|
DYRK3
|
109
|
2
|
|
EF2K
|
103
|
18
|
|
EIF2AK3
|
104
|
2
|
|
EPH-A2
|
102
|
3
|
|
EPH-A4
|
113
|
19
|
|
EPH-B1
|
88
|
4
|
|
EPH-B2
|
115
|
21
|
|
EPH-B3
|
119
|
7
|
|
EPH-B4
|
85
|
18
|
|
ERK1
|
101
|
6
|
|
ERK2
|
100
|
7
|
|
ERK8
|
89
|
8
|
|
FGF-R1
|
97
|
2
|
|
GCK
|
101
|
6
|
|
GSK3 beta
|
96
|
16
|
|
HER4
|
100
|
6
|
|
HIPK1
|
100
|
3
|
|
HIPK2
|
96
|
9
|
|
HIPK3
|
108
|
4
|
|
IGF-1R
|
105
|
3
|
|
IKK beta
|
99
|
7
|
|
IKK epsilon
|
109
|
7
|
|
IR
|
95
|
4
|
|
IRAK1
|
118
|
2
|
|
IRAK4
|
109
|
22
|
|
IRR
|
114
|
5
|
|
JAK2
|
99
|
2
|
|
JNK1
|
108
|
20
|
|
JNK2
|
97
|
6
|
|
JNK3
|
90
|
4
|
|
Lck
|
101
|
7
|
|
LKB1
|
100
|
11
|
|
MAPKAP-K2
|
101
|
14
|
|
MAPKAP-K3
|
109
|
7
|
|
MARK1
|
108
|
20
|
|
MARK2
|
102
|
10
|
|
MARK3
|
93
|
11
|
|
MARK4
|
143
|
3
|
|
MEKK1
|
114
|
7
|
|
MELK
|
110
|
9
|
|
MINK1
|
100
|
1
|
|
MKK1
|
111
|
32
|
|
MKK2
|
124
|
4
|
|
MKK6
|
89
|
6
|
|
MLK1
|
102
|
3
|
|
MLK3
|
97
|
3
|
|
MNK1
|
99
|
1
|
|
MNK2
|
123
|
41
|
|
MPSK1
|
118
|
17
|
|
MSK1
|
104
|
8
|
|
MST2
|
105
|
4
|
|
MST4
|
117
|
8
|
|
NEK2a
|
97
|
8
|
|
NEK6
|
100
|
6
|
|
NUAK1
|
107
|
7
|
|
OSR1
|
96
|
0
|
|
p38 alpha MAPK
|
121
|
7
|
|
p38 beta MAPK
|
110
|
18
|
|
p38 delta MAPK
|
97
|
4
|
|
p38 gamma MAPK
|
110
|
0
|
|
PAK2
|
109
|
2
|
|
PAK4
|
101
|
0
|
|
PAK5
|
92
|
7
|
|
PAK6
|
102
|
4
|
|
PDK1
|
38
|
10
|
|
PHK
|
117
|
19
|
|
PIM1
|
105
|
2
|
|
PIM2
|
105
|
5
|
|
PIM3
|
108
|
11
|
|
PKA
|
112
|
7
|
|
PKB alpha
|
97
|
1
|
|
PKB beta
|
96
|
10
|
|
PKC alpha
|
91
|
11
|
|
PKC gamma
|
103
|
11
|
|
PKC zeta
|
106
|
13
|
|
PKD1
|
80
|
14
|
|
PLK1
|
107
|
9
|
|
PRAK
|
100
|
4
|
|
PRK2
|
113
|
14
|
|
RIPK2
|
105
|
9
|
|
ROCK 2
|
112
|
7
|
|
RSK1
|
93
|
3
|
|
RSK2
|
98
|
8
|
|
S6K1
|
97
|
10
|
|
SGK1
|
102
|
2
|
|
SmMLCK
|
97
|
14
|
|
Src
|
100
|
3
|
|
SRPK1
|
114
|
12
|
|
STK33
|
107
|
11
|
|
SYK
|
88
|
4
|
|
TAK1
|
103
|
5
|
|
TAO1
|
126
|
1
|
|
TBK1
|
132
|
13
|
|
TESK1
|
88
|
4
|
|
TIE2
|
100
|
10
|
|
TLK1
|
103
|
18
|
|
TrkA
|
98
|
5
|
|
TSSK1
|
103
|
6
|
|
TTBK1
|
110
|
4
|
|
TTK
|
100
|
11
|
|
VEGFR1
|
100
|
3
|
|
YES1
|
105
|
12
|
|
ZAP70
|
106
|
3
|
Screen Conc:
10.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
ABL
|
98
|
4
|
|
AMPK
|
99
|
11
|
|
ASK1
|
92
|
6
|
|
Aurora A
|
103
|
2
|
|
Aurora B
|
64
|
12
|
|
BRK
|
119
|
0
|
|
BRSK1
|
92
|
14
|
|
BRSK2
|
79
|
5
|
|
BTK
|
110
|
16
|
|
CAMK1
|
51
|
5
|
|
CAMKK beta
|
90
|
2
|
|
CDK2-Cyclin A
|
95
|
12
|
|
CHK1
|
95
|
19
|
|
CHK2
|
100
|
4
|
|
CK1 delta
|
113
|
10
|
|
CK2
|
107
|
13
|
|
CLK2
|
74
|
1
|
|
CSK
|
101
|
9
|
|
DAPK1
|
91
|
5
|
|
DYRK1A
|
79
|
4
|
|
DYRK2
|
83
|
9
|
|
DYRK3
|
93
|
4
|
|
EF2K
|
107
|
11
|
|
EIF2AK3
|
96
|
2
|
|
EPH-A2
|
86
|
14
|
|
EPH-A4
|
107
|
4
|
|
EPH-B1
|
90
|
4
|
|
EPH-B2
|
121
|
17
|
|
EPH-B3
|
113
|
18
|
|
EPH-B4
|
87
|
16
|
|
ERK1
|
95
|
1
|
|
ERK2
|
101
|
2
|
|
ERK8
|
94
|
2
|
|
FGF-R1
|
75
|
10
|
|
GCK
|
94
|
1
|
|
GSK3 beta
|
64
|
12
|
|
HER4
|
98
|
13
|
|
HIPK1
|
86
|
0
|
|
HIPK2
|
90
|
15
|
|
HIPK3
|
91
|
0
|
|
IGF-1R
|
103
|
4
|
|
IKK beta
|
99
|
4
|
|
IKK epsilon
|
95
|
5
|
|
IR
|
93
|
17
|
|
IRAK1
|
108
|
6
|
|
IRAK4
|
110
|
26
|
|
IRR
|
105
|
14
|
|
JAK2
|
101
|
2
|
|
JNK1
|
114
|
17
|
|
JNK2
|
95
|
8
|
|
JNK3
|
101
|
4
|
|
Lck
|
91
|
11
|
|
LKB1
|
93
|
1
|
|
MAPKAP-K2
|
90
|
14
|
|
MAPKAP-K3
|
74
|
4
|
|
MARK1
|
107
|
6
|
|
MARK2
|
88
|
5
|
|
MARK3
|
83
|
11
|
|
MARK4
|
83
|
4
|
|
MEKK1
|
112
|
2
|
|
MELK
|
99
|
2
|
|
MINK1
|
87
|
17
|
|
MKK1
|
95
|
1
|
|
MKK2
|
135
|
1
|
|
MKK6
|
108
|
17
|
|
MLK1
|
50
|
3
|
|
MLK3
|
46
|
3
|
|
MNK1
|
99
|
4
|
|
MNK2
|
112
|
14
|
|
MPSK1
|
106
|
3
|
|
MSK1
|
106
|
1
|
|
MST2
|
100
|
10
|
|
MST4
|
86
|
17
|
|
NEK2a
|
96
|
11
|
|
NEK6
|
98
|
11
|
|
NUAK1
|
98
|
16
|
|
OSR1
|
83
|
3
|
|
p38 alpha MAPK
|
114
|
11
|
|
p38 beta MAPK
|
115
|
9
|
|
p38 delta MAPK
|
94
|
2
|
|
p38 gamma MAPK
|
105
|
1
|
|
PAK2
|
79
|
6
|
|
PAK4
|
67
|
0
|
|
PAK5
|
64
|
3
|
|
PAK6
|
89
|
0
|
|
PDK1
|
7
|
1
|
|
PHK
|
119
|
22
|
|
PIM1
|
76
|
2
|
|
PIM2
|
85
|
4
|
|
PIM3
|
95
|
10
|
|
PKA
|
111
|
4
|
|
PKB alpha
|
90
|
16
|
|
PKB beta
|
77
|
13
|
|
PKC alpha
|
96
|
7
|
|
PKC gamma
|
102
|
31
|
|
PKC zeta
|
88
|
10
|
|
PKD1
|
75
|
4
|
|
PLK1
|
121
|
2
|
|
PRAK
|
95
|
5
|
|
PRK2
|
103
|
6
|
|
RIPK2
|
98
|
7
|
|
ROCK 2
|
108
|
14
|
|
RSK1
|
114
|
1
|
|
RSK2
|
85
|
1
|
|
S6K1
|
98
|
3
|
|
SGK1
|
102
|
5
|
|
SmMLCK
|
89
|
4
|
|
Src
|
75
|
3
|
|
SRPK1
|
101
|
10
|
|
STK33
|
79
|
10
|
|
SYK
|
82
|
8
|
|
TAK1
|
54
|
4
|
|
TAO1
|
119
|
4
|
|
TBK1
|
102
|
17
|
|
TESK1
|
107
|
6
|
|
TIE2
|
96
|
6
|
|
TLK1
|
99
|
4
|
|
TrkA
|
78
|
19
|
|
TSSK1
|
86
|
9
|
|
TTBK1
|
106
|
7
|
|
TTK
|
95
|
0
|
|
VEGFR1
|
112
|
25
|
|
YES1
|
95
|
5
|
|
ZAP70
|
128
|
30
|
