Inhibitor | Merck 7 (PDK1)  

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
ABL	106	0
AMPK	97	9
ASK1	110	6
Aurora A	110	6
Aurora B	105	16
BRK	120	15
BRSK1	118	1
BRSK2	118	18
BTK	109	1
CAMK1	95	9
CAMKK beta	119	30
CDK2-Cyclin A	90	1
CHK1	96	4
CHK2	102	10
CK1 delta	103	9
CK2	111	1
CLK2	106	6
CSK	109	13
DAPK1	106	18
DYRK1A	113	4
DYRK2	110	1
DYRK3	109	9
EF2K	95	11
EIF2AK3	107	9
EPH-A2	94	29
EPH-A4	95	2
EPH-B1	87	0
EPH-B2	118	2
EPH-B3	114	1
EPH-B4	95	24
ERK1	93	5
ERK2	102	1
ERK8	92	1
FGF-R1	96	5
GCK	102	7
GSK3 beta	97	8
HER4	102	7
HIPK1	99	4
HIPK2	92	11
HIPK3	99	0
IGF-1R	105	4
IKK beta	102	0
IKK epsilon	103	11
IR	99	4
IRAK1	117	8
IRAK4	110	7
IRR	101	4
JAK2	98	1
JNK1	100	10
JNK2	93	9
JNK3	101	4
Lck	109	9
LKB1	102	3
MAPKAP-K2	99	9
MAPKAP-K3	116	1
MARK1	111	20
MARK2	105	5
MARK3	99	12
MARK4	150	3
MEKK1	110	12
MELK	97	17
MINK1	92	1
MKK1	100	16
MKK2	121	13
MKK6	94	6
MLK1	119	16
MLK3	104	16
MNK1	106	8
MNK2	117	11
MPSK1	101	9
MSK1	101	5
MST2	102	7
MST4	101	2
NEK2a	107	3
NEK6	104	2
NUAK1	115	12
OSR1	97	5
p38 alpha MAPK	114	7
p38 beta MAPK	100	1
p38 delta MAPK	91	12
p38 gamma MAPK	98	1
PAK2	113	11
PAK4	102	14
PAK5	104	5
PAK6	102	2
PDK1	90	10
PHK	100	4
PIM1	101	4
PIM2	107	6
PIM3	103	4
PKA	105	1
PKB alpha	96	4
PKB beta	98	4
PKC alpha	99	5
PKC gamma	91	0
PKC zeta	104	5
PKD1	90	10
PLK1	118	14
PRAK	108	11
PRK2	108	3
RIPK2	102	2
ROCK 2	105	8
RSK1	95	17
RSK2	102	5
S6K1	103	1
SGK1	106	2
SmMLCK	97	2
Src	103	13
SRPK1	107	1
STK33	92	13
SYK	99	10
TAK1	97	8
TAO1	111	6
TBK1	109	16
TESK1	98	11
TIE2	104	4
TLK1	97	2
TrkA	113	2
TSSK1	93	4
TTBK1	101	10
TTK	99	0
VEGFR1	106	2
YES1	104	12
ZAP70	102	1

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	105	4
AMPK	99	7
ASK1	105	15
Aurora A	110	1
Aurora B	104	9
BRK	129	10
BRSK1	102	13
BRSK2	90	4
BTK	108	1
CAMK1	92	1
CAMKK beta	104	8
CDK2-Cyclin A	91	6
CHK1	94	0
CHK2	106	7
CK1 delta	110	8
CK2	103	12
CLK2	95	18
CSK	98	6
DAPK1	113	4
DYRK1A	97	8
DYRK2	101	5
DYRK3	109	2
EF2K	103	18
EIF2AK3	104	2
EPH-A2	102	3
EPH-A4	113	19
EPH-B1	88	4
EPH-B2	115	21
EPH-B3	119	7
EPH-B4	85	18
ERK1	101	6
ERK2	100	7
ERK8	89	8
FGF-R1	97	2
GCK	101	6
GSK3 beta	96	16
HER4	100	6
HIPK1	100	3
HIPK2	96	9
HIPK3	108	4
IGF-1R	105	3
IKK beta	99	7
IKK epsilon	109	7
IR	95	4
IRAK1	118	2
IRAK4	109	22
IRR	114	5
JAK2	99	2
JNK1	108	20
JNK2	97	6
JNK3	90	4
Lck	101	7
LKB1	100	11
MAPKAP-K2	101	14
MAPKAP-K3	109	7
MARK1	108	20
MARK2	102	10
MARK3	93	11
MARK4	143	3
MEKK1	114	7
MELK	110	9
MINK1	100	1
MKK1	111	32
MKK2	124	4
MKK6	89	6
MLK1	102	3
MLK3	97	3
MNK1	99	1
MNK2	123	41
MPSK1	118	17
MSK1	104	8
MST2	105	4
MST4	117	8
NEK2a	97	8
NEK6	100	6
NUAK1	107	7
OSR1	96	0
p38 alpha MAPK	121	7
p38 beta MAPK	110	18
p38 delta MAPK	97	4
p38 gamma MAPK	110	0
PAK2	109	2
PAK4	101	0
PAK5	92	7
PAK6	102	4
PDK1	38	10
PHK	117	19
PIM1	105	2
PIM2	105	5
PIM3	108	11
PKA	112	7
PKB alpha	97	1
PKB beta	96	10
PKC alpha	91	11
PKC gamma	103	11
PKC zeta	106	13
PKD1	80	14
PLK1	107	9
PRAK	100	4
PRK2	113	14
RIPK2	105	9
ROCK 2	112	7
RSK1	93	3
RSK2	98	8
S6K1	97	10
SGK1	102	2
SmMLCK	97	14
Src	100	3
SRPK1	114	12
STK33	107	11
SYK	88	4
TAK1	103	5
TAO1	126	1
TBK1	132	13
TESK1	88	4
TIE2	100	10
TLK1	103	18
TrkA	98	5
TSSK1	103	6
TTBK1	110	4
TTK	100	11
VEGFR1	100	3
YES1	105	12
ZAP70	106	3

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	98	4
AMPK	99	11
ASK1	92	6
Aurora A	103	2
Aurora B	64	12
BRK	119	0
BRSK1	92	14
BRSK2	79	5
BTK	110	16
CAMK1	51	5
CAMKK beta	90	2
CDK2-Cyclin A	95	12
CHK1	95	19
CHK2	100	4
CK1 delta	113	10
CK2	107	13
CLK2	74	1
CSK	101	9
DAPK1	91	5
DYRK1A	79	4
DYRK2	83	9
DYRK3	93	4
EF2K	107	11
EIF2AK3	96	2
EPH-A2	86	14
EPH-A4	107	4
EPH-B1	90	4
EPH-B2	121	17
EPH-B3	113	18
EPH-B4	87	16
ERK1	95	1
ERK2	101	2
ERK8	94	2
FGF-R1	75	10
GCK	94	1
GSK3 beta	64	12
HER4	98	13
HIPK1	86	0
HIPK2	90	15
HIPK3	91	0
IGF-1R	103	4
IKK beta	99	4
IKK epsilon	95	5
IR	93	17
IRAK1	108	6
IRAK4	110	26
IRR	105	14
JAK2	101	2
JNK1	114	17
JNK2	95	8
JNK3	101	4
Lck	91	11
LKB1	93	1
MAPKAP-K2	90	14
MAPKAP-K3	74	4
MARK1	107	6
MARK2	88	5
MARK3	83	11
MARK4	83	4
MEKK1	112	2
MELK	99	2
MINK1	87	17
MKK1	95	1
MKK2	135	1
MKK6	108	17
MLK1	50	3
MLK3	46	3
MNK1	99	4
MNK2	112	14
MPSK1	106	3
MSK1	106	1
MST2	100	10
MST4	86	17
NEK2a	96	11
NEK6	98	11
NUAK1	98	16
OSR1	83	3
p38 alpha MAPK	114	11
p38 beta MAPK	115	9
p38 delta MAPK	94	2
p38 gamma MAPK	105	1
PAK2	79	6
PAK4	67	0
PAK5	64	3
PAK6	89	0
PDK1	7	1
PHK	119	22
PIM1	76	2
PIM2	85	4
PIM3	95	10
PKA	111	4
PKB alpha	90	16
PKB beta	77	13
PKC alpha	96	7
PKC gamma	102	31
PKC zeta	88	10
PKD1	75	4
PLK1	121	2
PRAK	95	5
PRK2	103	6
RIPK2	98	7
ROCK 2	108	14
RSK1	114	1
RSK2	85	1
S6K1	98	3
SGK1	102	5
SmMLCK	89	4
Src	75	3
SRPK1	101	10
STK33	79	10
SYK	82	8
TAK1	54	4
TAO1	119	4
TBK1	102	17
TESK1	107	6
TIE2	96	6
TLK1	99	4
TrkA	78	19
TSSK1	86	9
TTBK1	106	7
TTK	95	0
VEGFR1	112	25
YES1	95	5
ZAP70	128	30