Inhibitor | Wyeth PDK1 Inhibitor Compound 1  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Wyeth PDK1 Inhibitor Compound 1   C19H22Cl4N4O2 480.21 PDK1 Gopalsamy A. (2007) Journal of Medicinal Chemistry 50 (23) 5547-5549

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
AMPK 46 1
ASK1 67 7
Aurora A 103 8
Aurora B 97 5
BRSK1 82 1
BRSK2 84 5
BTK 87 1
CAMK1 91 1
CAMKK beta 87 5
CDK2-Cyclin A 74 2
CHK1 53 3
CHK2 46 14
CK1 delta 83 1
CK2 89 7
CLK2 61 4
CSK 85 5
DAPK1 81 1
DYRK1A 100 1
DYRK2 91 11
DYRK3 89 2
EF2K 83 3
EPH-A2 109 14
EPH-A4 95 2
EPH-B1 105 3
EPH-B2 112 3
EPH-B3 93 13
EPH-B4 98 0
ERK1 72 3
ERK2 69 3
ERK8 85 6
FGF-R1 76 0
GCK 11 0
GSK3 beta 64 2
HER4 73 5
HIPK1 78 1
HIPK2 56 1
HIPK3 98 0
IGF-1R 99 4
IKK beta 56 6
IKK epsilon
8
 0
IR 65 12
IRAK4 61 0
IRR 73 2
JAK2 14 1
JNK1 90 3
JNK2 91 10
JNK3 97 6
Lck 84 11
LKB1 77 4
MAPKAP-K2 101 5
MAPKAP-K3 94 6
MARK1 55 3
MARK2 73 3
MARK3 35 0
MARK4 65 7
MEKK1 51 9
MELK 71 3
MINK1 15 2
MKK1
10
 0
MKK2 34 4
MKK6 95 2
MLK1 26 2
MLK3
8
 1
MNK1 114 9
MNK2 123 3
MSK1 82 5
MST2 15 1
MST4 32 0
NEK2a 55 6
NEK6 99 6
NUAK1 30 1
p38 alpha MAPK 100 3
p38 beta MAPK 95 4
p38 delta MAPK 92 1
p38 gamma MAPK 98 9
PAK2 77 7
PAK4 72 3
PAK5 76 7
PAK6 64 0
PDK1 35 4
PHK 69 2
PIM1 94 7
PIM2 91 7
PIM3 72 6
PKA 86 1
PKB alpha 94 9
PKB beta 86 3
PKC alpha 79 4
PKC zeta 89 3
PKD1 19 5
PLK1 79 5
PRAK 86 3
PRK2 71 2
RIPK2 82 6
ROCK 2 54 1
RSK1 14 1
RSK2 15 1
S6K1 82 5
SGK1 98 2
SmMLCK 77 2
Src 86 2
SRPK1 96 7
SYK 74 5
TAK1 41 7
TAO1 59 2
TBK1 11 0
TrkA 73 4
TTK 68 1
VEGFR1 47 5
YES1 81 1
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 20 3
ASK1 21 1
Aurora A 82 3
Aurora B 68 6
BRSK1 67 6
BRSK2 77 6
BTK 70 7
CAMK1 82 3
CAMKK beta 91 2
CDK2-Cyclin A 69 8
CHK1 20 1
CHK2
7
 2
CK1 delta 70 5
CK2 75 1
CLK2 27 0
CSK 88 1
DAPK1 59 8
DYRK1A 55 2
DYRK2 78 1
DYRK3 71 2
EF2K 77 3
EPH-A2 99 7
EPH-A4 87 2
EPH-B1 102 0
EPH-B2 105 8
EPH-B3 91 1
EPH-B4 95 1
ERK1 31 2
ERK2 58 7
ERK8 48 1
FGF-R1 49 0
GCK
4
 1
GSK3 beta 32 2
HER4 46 3
HIPK1 53 3
HIPK2 23 7
HIPK3 69 5
IGF-1R 72 10
IKK beta 31 0
IKK epsilon
9
 1
IR 32 4
IRAK4 46 4
IRR 54 2
JAK2
6
 1
JNK1 80 8
JNK2 94 8
JNK3 63 4
Lck 65 11
LKB1 84 11
MAPKAP-K2 97 0
MAPKAP-K3 79 3
MARK1 34 2
MARK2 72 9
MARK3 18 3
MARK4 40 7
MEKK1 40 11
MELK 61 3
MINK1
7
 2
MKK1
2
 3
MKK2 16 3
MKK6 100 1
MLK1 27 2
MLK3
4
 1
MNK1 90 3
MNK2 115 2
MSK1 71 5
MST2
4
 1
MST4 14 1
NEK2a 18 3
NEK6 95 3
NUAK1 25 7
p38 alpha MAPK 116 7
p38 beta MAPK 90 1
p38 delta MAPK 84 13
p38 gamma MAPK 109 8
PAK2 50 1
PAK4 42 5
PAK5 38 0
PAK6 56 3
PDK1 14 1
PHK 26 1
PIM1 69 3
PIM2 95 1
PIM3 29 4
PKA 77 1
PKB alpha 84 0
PKB beta 64 2
PKC alpha 62 5
PKC zeta 115 4
PKD1
10
 1
PLK1 45 2
PRAK 82 8
PRK2 34 3
RIPK2 70 6
ROCK 2 15 4
RSK1
2
 1
RSK2
9
 0
S6K1 57 6
SGK1 86 2
SmMLCK 56 2
Src 89 10
SRPK1 105 10
SYK 43 4
TAK1
5
 2
TAO1 28 6
TBK1 17 7
TrkA 56 4
TTK 44 1
VEGFR1 23 1
YES1 57 0
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 25 21
BRSK2 74 5
BTK 49 1
CAMK1 17 5
CAMKK beta 71 4
CDK2-Cyclin A 58 3
CHK1
2
 1
CHK2 13 2
CK1 delta 46 2
CK2 80 2
CSK 78 5
DYRK1A 55 5
DYRK2 51 5
DYRK3 53 3
EF2K 103 7
EPH-A2 70 1
EPH-B3 34 0
ERK1 48 1
ERK2 49 7
ERK8 18 1
FGF-R1 30 0
GSK3 beta 24 0
HIPK2 41 0
IGF-1R 38 7
IKK beta 50 1
IKK epsilon
6
 0
IR 53 2
IRR 36 4
JNK1 80 19
JNK2 86 1
Lck 24 2
MAPKAP-K2 105 55
MARK3
5
 0
MELK 34 13
MKK1
6
 4
MNK1 99 12
MNK2 93 2
MSK1 59 8
MST2
1
 0
MST4 35 7
NEK2a
6
 1
NEK6 79 8
p38 alpha MAPK 108 7
p38 beta MAPK 84 15
p38 delta MAPK 87 8
p38 gamma MAPK 86 3
PAK4 21 0
PAK5 25 1
PAK6 54 2
PDK1
3
 1
PHK 13 0
PIM1 36 12
PIM2 88 4
PIM3 21 1
PKA 53 8
PKB alpha 93 5
PKB beta 88 5
PKC alpha 23 1
PKC zeta 37 2
PKD1
2
 2
PLK1 26 5
PRAK 36 0
PRK2 16 1
ROCK 2 14 2
RSK1
3
 0
RSK2
4
 0
S6K1 34 0
SGK1 58 3
SmMLCK 33 5
Src 70 0
SRPK1 82 0
SYK 37 2
TBK1 18 2
VEGFR1 20 12
YES1 64 9