Inhibitor | Y-27632  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Y-27632   C14H21N3O • 2HCl • H2O 338.30 146986-50-7 448042 ROCK Watanabe K. (2007) Nature Biotech. 25 681 Chitaley K. (2001) Nat. Med. 7 119

Screening Results Chart

Screening Results Tables

Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 14 1
Aurora B 79 7
Aurora C 65 0
BRSK2 57 4
BTK 85 17
CAMK1 98 6
CAMKK alpha 107 6
CAMKK beta 75 5
CDK2-Cyclin A 50 1
CHK1 72 0
CHK2 100 1
CK1 delta 93 3
CK2 89 8
CSK 69 2
DYRK1A 81 5
DYRK2 86 4
DYRK3 89 9
EF2K 85 4
EPH-A2 106 3
EPH-B3 83 12
ERK1 98 0
ERK2 82 7
ERK8 94 1
FGF-R1 94 9
GCK 89 4
GSK3 beta 86 3
HER4 68 8
HIPK2 83 4
HIPK3 97 2
IGF-1R 98 5
IKK beta 78 1
IKK epsilon 76 8
IR 112 1
IRAK4 100 7
IRR 90 0
JNK1 79 8
JNK2 90 4
JNK3 92 0
Lck 73 4
LKB1 51 12
MAPKAP-K2 91 2
MAPKAP-K3 99 5
MARK3 69 3
MELK 64 0
MINK1 80 0
MKK1 96 1
MLK1 89 18
MLK3 109 3
MNK1 25 2
MNK2 54 2
MSK1 27 2
MST2 46 3
MST4 67 7
NEK2a 85 5
NEK6 91 9
NEK7 102 5
NUAK1 106 0
p38 alpha MAPK 105 4
p38 beta MAPK 108 3
p38 delta MAPK 87 4
p38 gamma MAPK 102 1
PAK4 89 2
PAK5 89 3
PAK6 88 2
PDK1 74 0
PHK 49 5
PIM1 87 0
PIM2 91 2
PIM3 56 1
PKA 72 1
PKB alpha 73 2
PKB beta 86 0
PKC alpha 57 1
PKC zeta 55 7
PKD1 85 3
PLK1 78 3
PRAK 78 2
PRK2
3
 2
ROCK 2
7
 0
RSK1 21 1
RSK2 43 7
S6K1 93 0
SGK1 72 4
SmMLCK 91 7
Src 79 4
SRPK1 87 5
SYK 93 8
TBK1 69 8
TTK 73 2
VEGFR1 105 3
YES1 96 4