Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Cot-Tpl2 Inhibitor Compound 38 (Abbott)   C21H12F3N5OS 439.41 Cot-Tpl2 George D. Friedman M. (2008) Bioorganic and Medicinal Chemistry Letters 18 495…


10.00 87
Cot-Tpl2 Inhibitor Compound 41 (Abbott)   C21H14N6O2S 414.44 Cot-Tpl2 George D. Friedman M. (2008) Bioorganic and Medicinal Chemistry Letters 18 495…


10.00 87
Cot-Tpl2 Inhibitor Compound 41 (Abbott)   C21H14N6O2S 414.44 Cot-Tpl2 George D. Friedman M. (2008) Bioorganic and Medicinal Chemistry Letters 18 495…


1.00 91
CP-690550 (Tasocitinib)   C16H20N6O 312.38 JAKs Manshouri T. (2008) Cancer Sci. 99(6) 1265-73


1.00 65
CP-690550 (Tasocitinib)   C16H20N6O 312.38 JAKs Manshouri T. (2008) Cancer Sci. 99(6) 1265-73


0.10 104
Crenolanib   C26H29N5O2 443.50 FLT3 Smith CC (2014 )Proc Natl Acad Sci U S A Apr 8 111(14) 5319-24


1.00 26
Curcumin   C21H20O6 368.40 Inhibits EGF receptor Cui L. (2007) Antimicrob. Agents Chemother. 51 488
Salvioli S. (2007) eCAM 4 181
WO2000070949
10.00 31
CZC-25146   C22H25FN6O4S 488.54 LRRK2 Ramsden N. (2011) ASC Chemical Biology


1.00 83
CZC-25146   C22H25FN6O4S 488.54 LRRK2 Ramsden N. (2011) ASC Chemical Biology


10.00 22
D 4476   C23H18N4O3 398.41 CK1 Liverton N.J. (1999) J. Med. Chem 42 2180-2190

WO2008066626
10.00 81