Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
GSK2334470   C25H34N8O 462.59 PDK1 Najafov A. (2011) Biochem. J. 433 357-69


 0.10 119
GSK2334470   C25H34N8O 462.59 PDK1 Najafov A. (2011) Biochem. J. 433 357-69


 1.00 106
GSK2578215A   C24H18FN3O2 399.42 LRRK2 Reith A. (2012) Bioorg. Med. Chem. Lett.

WO2011038572
 10.00 140
GSK2578215A   C24H18FN3O2 399.42 LRRK2 Reith A. (2012) Bioorg. Med. Chem. Lett.

WO2011038572
 1.00 120
GSK2606414   C24H20F3N5O 451.44 PERK Axten JM. (2012) J. Med. Chem. 23 55(16) 7193-207


 0.10 92
GSK2606414   C24H20F3N5O 451.44 PERK Axten JM. (2012) J. Med. Chem. 23 55(16) 7193-207


 1.00 45
GSK269962A   C29H30N8O5 570.61 ROCK Doe C. (2007) J Pharmacol Exp Ther 320 89-98


 0.10 86
GSK269962A   C29H30N8O5 570.61 ROCK Doe C. (2007) J Pharmacol Exp Ther 320 89-98


 1.00 111
GSK429286   C21H16F4N4O2 432.37 ROCK Goodman K. (2007) J. Med. Chem. 50 (1), 6-9
Nichols (2009) Biochem.J. 424 47

1.00 58
GSK461364   C27H28F3N5O2S 543.60 PLK1 T. R. Rheault (2010) Bioorg. Med. Chem. Lett. 20(15) 4587-92
K. A. Emmitte (2009) Bioorg. Med. Chem. Lett. 19(6) 1694-7

1.00 102