Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Dasatinib   C22H26ClN7O2S 487.00 BCR-ABL, Src, Multiple Tyrosine kinases targeted Kantarjian H. N Engl J Med. (2010) 2260-70

WO2009094556
 1.00 1
Dasatinib   C22H26ClN7O2S 487.00 BCR-ABL, Src, Multiple Tyrosine kinases targeted Kantarjian H. N Engl J Med. (2010) 2260-70

WO2009094556
 0.10 1
Dimethyl fumarate C6H8O4 144.13 Peng H. (2112) J Biol Chem. 287(33) 28017-26
Gesser B. (2007) Journal of Investigative Dermatology 27(9) 2129-37

100.00 116
Dimethyl fumarate C6H8O4 144.13 Peng H. (2112) J Biol Chem. 287(33) 28017-26
Gesser B. (2007) Journal of Investigative Dermatology 27(9) 2129-37

118
Dimethyl fumarate C6H8O4 144.13 Peng H. (2112) J Biol Chem. 287(33) 28017-26
Gesser B. (2007) Journal of Investigative Dermatology 27(9) 2129-37

10.00 114
EGCG (Epigallocatechin Gallate)   C22H18O11 458.40 PKC Dell'Aica I. (2004) EMBO Rep. 5 418-422
Tachibana H. (2004) Nat. Struct. Mol. Biol. 11 380
WO2001051048
 10.00 12
EMD638683   C18H18F2N 364.34 SGK1 Miyayama T (2014) Environ Toxicol Pharmacol 38(2) 374-8

US2011060050
 10.00 83
EMD638683   C18H18F2N 364.34 SGK1 Miyayama T (2014) Environ Toxicol Pharmacol 38(2) 374-8

US2011060050
 1.00 73
ER-27319   C20H22N2O5 370.40 SYK Moriya K. (1997) Proc. Natl. Acad. Sci. USA 94 12539-12544


 1.00 84
ER-27319   C20H22N2O5 370.40 SYK Moriya K. (1997) Proc. Natl. Acad. Sci. USA 94 12539-12544


 10.00 100