Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
BMS345541 (IKK Inhibitor III)   C14H17N5 255.32 IKBKB Du Z. (2012) J Interferon Cytokine Res. 368-77

DE4329970
10.00 84
BML-258 (SK1-I)   C17H28ClNO2 313.86 SphK1 Paugh S.W. (2008) Blood 112 1382-1391


10.00 109
BMS345541 (IKK Inhibitor III)   C14H17N5 255.32 IKBKB Du Z. (2012) J Interferon Cytokine Res. 368-77

DE4329970
1.00 115
BX-320   C23H31BrN8O3 547.45 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874

WO2004048343
1.00 100
BX-320   C23H31BrN8O3 547.45 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874

WO2004048343
10.00 62
BX-517   C15H14N4O2 282.30 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3814-3818

CN102639566
0.10 42
BX-517   C15H14N4O2 282.30 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3814-3818

CN102639566
0.00 77
BX-517   C15H14N4O2 282.30 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3814-3818

CN102639566
0.01 60
BX-517 Analog (compound 7b)   C19H15N5O2 345.35 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3819-3825


10.00 3
BX-517 Analog (compound 7b)   C19H15N5O2 345.35 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3819-3825


1.00 8