Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
ETP 46464   C30H22N4O2 470.52 ATRi Toledo L.I. (2011) Nature structural and molecular biology 18 721-727


10.00 93
ETP 46464   C30H22N4O2 470.52 ATRi Toledo L.I. (2011) Nature structural and molecular biology 18 721-727


1.00 92
Febuxostat (TMX-67, Adenuric, Uloric)   C16H16N2O3S 316.37 Xanthine oxidase (XO) Gaffo AL. (2010 ) Core Evid. 4 25-36
Grabowski B (2010) Br J Clin Pharmacol. 70 57-64

1.00 117
Febuxostat (TMX-67, Adenuric, Uloric)   C16H16N2O3S 316.37 Xanthine oxidase (XO) Gaffo AL. (2010 ) Core Evid. 4 25-36
Grabowski B (2010) Br J Clin Pharmacol. 70 57-64

10.00 90
Fostamatinib   C23H26FN6O9P 580.46

1.00 64
Fostamatinib   C23H26FN6O9P 580.46

0.10 87
Fostamatinib   C23H26FN6O9P 580.46

10.00 17
GDC-0941   C23H29N7O3S2Cl2 586.57 PI3K Folkes AJ. (2008) J Med Chem. 5522-32

WO2007129161
0.10 87
GDC-0941   C23H29N7O3S2Cl2 586.57 PI3K Folkes AJ. (2008) J Med Chem. 5522-32

WO2007129161
10.00 40
GDC-0941   C23H29N7O3S2Cl2 586.57 PI3K Folkes AJ. (2008) J Med Chem. 5522-32

WO2007129161
1.00 84