Inhibitor | Cot-Tpl2 Inhibitor Compound 38 (Abbott)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Cot-Tpl2 Inhibitor Compound 38 (Abbott)   C21H12F3N5OS 439.41 Cot-Tpl2 George D. Friedman M. (2008) Bioorganic and Medicinal Chemistry Letters 18 495…

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 81 8
ASK1 95 4
Aurora A 108 9
Aurora B 81 3
BRSK1 138 7
BRSK2 115 1
BTK 98 1
CAMK1 93 3
CAMKK beta 105 6
CDK2-Cyclin A 79 4
CHK1 118 9
CHK2 102 1
CK1 delta 86 1
CK2 20 2
CLK2 73 7
CSK 100 2
DAPK1 47 1
DYRK1A 27 3
DYRK2 16 1
DYRK3 18 3
EF2K 106 6
EPH-A2 126 0
EPH-A4 109 4
EPH-B1 108 3
EPH-B2 111 10
EPH-B3 122 4
EPH-B4 109 4
ERK1 101 15
ERK2 114 15
ERK8 34 3
FGF-R1 102 6
GCK 68 5
GSK3 beta 63 6
HER4 94 0
HIPK1 65 8
HIPK2 22 2
HIPK3 63 1
IGF-1R 74 7
IKK beta 89 3
IKK epsilon 109 5
IR 100 10
IRAK4 90 1
IRR 67 2
JAK2 99 2
JNK1 103 7
JNK2 113 15
JNK3 85 6
Lck 100 2
LKB1 85 1
MAPKAP-K2 97 5
MAPKAP-K3 109 7
MARK1 99 0
MARK2 83 6
MARK3 100 12
MARK4 106 12
MEKK1 109 13
MELK 81 11
MINK1 96 4
MKK1 87 10
MKK2 87 12
MKK6 94 5
MLK1 126 4
MLK3 91 0
MNK1 89 2
MNK2 105 7
MSK1 90 8
MST2 93 2
MST4 118 7
NEK2a 108 1
NEK6 93 7
NUAK1 128 7
p38 alpha MAPK 102 3
p38 beta MAPK 102 5
p38 delta MAPK 113 1
p38 gamma MAPK 91 5
PAK2 109 10
PAK4 121 2
PAK5 103 2
PAK6 121 14
PDK1 103 2
PHK 102 1
PIM1 70 3
PIM2 87 14
PIM3 74 0
PKA 101 1
PKB alpha 99 10
PKB beta 106 1
PKC alpha 107 3
PKC zeta 126 13
PKD1 109 5
PLK1 83 11
PRAK 110 4
PRK2 98 1
RIPK2 83 11
ROCK 2 90 6
RSK1 122 3
RSK2 132 2
S6K1 98 1
SGK1 93 10
SmMLCK 94 1
Src 108 10
SRPK1 112 1
SYK 114 5
TAK1 104 13
TAO1 65 0
TBK1 109 15
TrkA 104 8
TTK 83 11
VEGFR1 96 7
YES1 100 8
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 51 1
ASK1 72 7
Aurora A 63 2
Aurora B 40 5
BRSK1 104 12
BRSK2 105 0
BTK 84 3
CAMK1 73 3
CAMKK beta 44 4
CDK2-Cyclin A 47 4
CHK1 65 5
CHK2 37 8
CK1 delta 41 3
CK2
4
 0
CLK2 14 0
CSK 95 6
DAPK1 17 0
DYRK1A
5
 1
DYRK2
3
 1
DYRK3
3
 1
EF2K 80 6
EPH-A2 94 3
EPH-A4 106 1
EPH-B1 100 12
EPH-B2 120 8
EPH-B3 104 11
EPH-B4 110 10
ERK1 82 9
ERK2 95 5
ERK8
4
 1
FGF-R1 76 1
GCK 17 1
GSK3 beta 14 1
HER4 89 3
HIPK1 12 1
HIPK2 11 2
HIPK3
10
 0
IGF-1R 74 3
IKK beta 56 6
IKK epsilon 60 0
IR 91 1
IRAK4 88 12
IRR 27 4
JAK2 46 1
JNK1 101 3
JNK2 100 5
JNK3 96 7
Lck 98 7
LKB1 64 5
MAPKAP-K2 94 5
MAPKAP-K3 95 6
MARK1 72 1
MARK2 84 2
MARK3 51 3
MARK4 97 11
MEKK1 93 10
MELK 19 7
MINK1 87 3
MKK1 31 1
MKK2 70 7
MKK6 100 4
MLK1 91 0
MLK3 61 10
MNK1 55 0
MNK2 64 1
MSK1 22 3
MST2 76 5
MST4 71 5
NEK2a 113 14
NEK6 83 13
NUAK1 88 4
p38 alpha MAPK 107 1
p38 beta MAPK 100 2
p38 delta MAPK 77 4
p38 gamma MAPK 73 13
PAK2 101 5
PAK4 97 5
PAK5 94 9
PAK6 110 1
PDK1 97 3
PHK 82 0
PIM1 17 1
PIM2 36 1
PIM3 31 2
PKA 89 0
PKB alpha 73 1
PKB beta 98 6
PKC alpha 59 1
PKC zeta 60 5
PKD1 95 3
PLK1 16 1
PRAK 67 1
PRK2 54 5
RIPK2 30 7
ROCK 2 93 12
RSK1 57 1
RSK2 88 6
S6K1 50 5
SGK1 39 4
SmMLCK 42 5
Src 95 3
SRPK1 105 2
SYK 102 9
TAK1 67 6
TAO1 30 2
TBK1 63 6
TrkA 71 1
TTK 63 1
VEGFR1 29 1
YES1 87 5