Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Genentech LRRK2 inhibitor compound 18 (GNE-7915)   C19H21F4N5O3 443.40 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33


 1.00 104
Genentech LRRK2 inhibitor compound 18 (GNE-7915)   C19H21F4N5O3 443.40 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33


 10.00 104
Genentech LRRK2 inhibitor compound 19   C20H21F4N5O3 455.41 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33


 1.00 89
Genentech LRRK2 inhibitor compound 19   C20H21F4N5O3 455.41 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33


 10.00 110
Genistein   C15H10O5 270.20 Tyrosine-kinases Constantinou A. and Huberman E. (1995) Proc. Soc. Exp. Biol. Med. 208 109
Wei H. (1995) Proc. Soc. Exp. Biol. Med. 208 124
WO1999045920
 25.00 74
Genistein   C15H10O5 270.20 Tyrosine-kinases Constantinou A. and Huberman E. (1995) Proc. Soc. Exp. Biol. Med. 208 109
Wei H. (1995) Proc. Soc. Exp. Biol. Med. 208 124
WO1999045920
 10.00 105
Imatinib   C29H31N7O 493.60 BCR-ABL, c-KIT, PDGFR Druker B. J. (2000) J. Clin. Invest. 105 3-7

WO2006039533
 1.00 77
Imatinib   C29H31N7O 493.60 BCR-ABL, c-KIT, PDGFR Druker B. J. (2000) J. Clin. Invest. 105 3-7

WO2006039533
 10.00 49
GSK2334470   C25H34N8O 462.59 PDK1 Najafov A. (2011) Biochem. J. 433 357-69


 10.00 98
GSK2334470   C25H34N8O 462.59 PDK1 Najafov A. (2011) Biochem. J. 433 357-69


 0.01 122