Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
BX-517 Analog (compound 7b)   C19H15N5O2 345.35 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3819-3825


 0.10 32
BX-795   C23H26IN7O2S 591.47 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874

WO2004048343
 1.00 66
BX-795   C23H26IN7O2S 591.47 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874

WO2004048343
 0.01 90
BX-795   C23H26IN7O2S 591.47 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874

WO2004048343
 10.00 11
BX-795   C23H26IN7O2S 591.47 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874

WO2004048343
 0.10 117
BX-912   C20H23BrN8O 471.35 PDK Feldman RI. (2005) J. Biol. Chem. 2005 May 20 280(20) 19867-74


 1.00 42
BX-912   C20H23BrN8O 471.35 PDK Feldman RI. (2005) J. Biol. Chem. 2005 May 20 280(20) 19867-74


 0.10 82
Caffeine   C8H10N4O2 194.19 ATM Islam M.S. (1998) Proc. Natl. Acad. Sci. USA 95 6145-6150


 1.00 85
Caffeine   C8H10N4O2 194.19 ATM Islam M.S. (1998) Proc. Natl. Acad. Sci. USA 95 6145-6150


 0.10 85
CAY10576   C22H19N3O5S2 469.50 IKKe

1.00 87