Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
SGK-Sanofi-14i   C18H15ClN6O3S SGK Halland, N (2015) ACS Medicinal Chemistry Letters 6 73-78


 1.00 99
SGK1-Sanofi-14g   C17H12Cl2N6O2S 435.29 SGK Halland, N (2015) ACS Medicinal Chemistry Letters 6 73-78


 1.00 101
SGK1-Sanofi-14h   C17H12Cl2N6O2S 435.29 SGK Halland, N (2015) ACS Medicinal Chemistry Letters , 6,73-78


 1.00 72
SGK1-Sanofi-14n   C17H12CIFN6O2S 418.83 SGK Halland, N (2015) ACS Medicinal Chemistry Letters 6 73-78


 1.00 77
SGK1-Sanofi-308-R   C23H23FN6O4S 498.53 SGK1
WO2014140065
 1.00 62
SGK1-Sanofi-308-S   C23H23FN6O4S 498.53 SGK1
WO2014140065
 1.00 66
SGK1-Sanofi-ex.290-R   C24H25ClN6O5S 545.01 SGK1
WO2014140065
 1.00 66
SGK1-Sanofi-ex.290-S   C24H25ClN6O5S 545.01 SGK1
WO2014140065
 1.00 76
Sirolimus   C51H79NO13 914.20 p70S6K, mTOR Powell D.J. (2003) Mol. Cell Biol. 23 7794
Braun W. (1995) FASEB J. 9 63

1.00 93
SL-327 (MEK1-2 Inhibitor)   C16H12F3N3S 335.40 MEK1, MEK2 Hetman M. (2002) J. Biol. Chem. 277 49577
Ohno M. (2001) Nat. Neurosci. 4 1238

10.00 85