Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
SL0101-1   C25H24O12 516.46 RSK Smith (2005) Cancer Res. 65 1027
Goden Sayeski (2006) Am. J. Cell. Physiol. 291 1308

10.00 88
Sodium salicylate   HOC6H4COONa 160.10 p38 Schwenger P. (1998) Mol Cell Biol. Jan 18(1) 78-84


1.00 81
Sodium salicylate   HOC6H4COONa 160.10 p38 Schwenger P. (1998) Mol Cell Biol. Jan 18(1) 78-84


10.00 48
Sodium valproate   C8H15NaO2 166.19 Histone deacetylase Phiel (2001) J.Biol.Chem. 276 36734
Kostrouchova (2007) Folia Biologica 53 37

1.00 86
Sodium valproate   C8H15NaO2 166.19 Histone deacetylase Phiel (2001) J.Biol.Chem. 276 36734
Kostrouchova (2007) Folia Biologica 53 37

10.00 89
Sodium valproate   C8H15NaO2 166.19 Histone deacetylase Phiel (2001) J.Biol.Chem. 276 36734
Kostrouchova (2007) Folia Biologica 53 37

50.00 99
SP600125 (JNK Inhibitor II, SAPK Inhibitor II)   C14H8N2O 220.20 JNK Shin M. Boyd Y.D. (2002) Biochim. Biophys. Acta 1589 311
Bennett B.L. (2001) Proc. Natl. Acad. Sci. USA 98 13681

1.00 58
Sphingosine Kinase Inhibitor (SKI II)   C15H11ClN2OS 339.20 SphK1 French (2003) Cancer Res. 63 5962.
French (2006) J.Pharmacol.Exp.Ther. 318 596

10.00 85
Sphingosine Kinase Inhibitor (SKI II)   C15H11ClN2OS 339.20 SphK1 French (2003) Cancer Res. 63 5962.
French (2006) J.Pharmacol.Exp.Ther. 318 596

1.00 94
SRC Inhibitor 1   C22H19N3O3 373.40 Src Tian G. (2001) Biochemistry 40 7084


10.00 25