Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
SB-505124   C20H21N3O2 · xHCl · yH2O 335.40 ALK Byfield (2004) Mol.Pharmacol. 65 744


0.10 107
SB-505124   C20H21N3O2 · xHCl · yH2O 335.40 ALK Byfield (2004) Mol.Pharmacol. 65 744


1.00 111
SB-590885 C27H27N5O2 453.54 B-Raf King (2006) Cancer Res. 66 11100


0.10 87
SB-590885 C27H27N5O2 453.54 B-Raf King (2006) Cancer Res. 66 11100


1.00 103
SB-590885 C27H27N5O2 453.54 B-Raf King (2006) Cancer Res. 66 11100


10.00 89
SB-747651A C16H22N8O 342.40 Naqvi (2012) Biochem. J. 441 (347–357)


0.10 85
SB-747651A C16H22N8O 342.40 Naqvi (2012) Biochem. J. 441 (347–357)


1.00 103
SB-747651A C16H22N8O 342.40 Naqvi (2012) Biochem. J. 441 (347–357)


10.00 78
SC514 ( IKK-2 Inhibitor)   C9H8N2OS2 224.30 IKK2 Baxter A. (2004) Bioorg. Med. Chem. Lett. 14 2817
Kishore N. (2003) J. Biol. Chem. 278 32861

10.00 83
SC514 ( IKK-2 Inhibitor)   C9H8N2OS2 224.30 IKK2 Baxter A. (2004) Bioorg. Med. Chem. Lett. 14 2817
Kishore N. (2003) J. Biol. Chem. 278 32861

20.00 71