Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 367 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Reference 2
Novartis 12a (PKD1)   C23H29F3N6O3 494.51 PKD1 Meredith E.L. (2010) J.Med.Chem. 53 5422-5438
NVP-BEZ 235   C30H25Cl2N5O 542.46 PI3K, Akt, mTOR Maira S. Stauffer F. (2008) Mol. Cancer. Ther. 7 1851-1863.
Olaratumab   PDGFRa
Olmutinib   C26H26N6O2S 486.60 EGFR
Orelabrutinib   C26H25N3O3 427.50 BTK
Osimertinib   C28H33N7O2 499.60 EGFR
OSU-03012 C26H19F3N4O 460.45 PDK1 Zhu J. (2004) Cancer Res. 64(12) 4309-18
OTSSP167 C25H28Cl2N4O2 487.42 MELK
Pacritinib   C28H32N4O3 472.60 JAK/IRAK
Palbociclib   C24H29N7O2 447.50 CDK4/6
Panitumumab EGFR
Parthenolide C15H20O3 248.32 IKKβ Kwok B.H. (2001) Chem. Biol. 8 759-766
Paxalisib   C18H22N8O2 382.40 PI3K/mTOR
Pazopanib   C21H24ClN7O2S VEGFR2, PDGFR, c-KIT
PCI-32765 (Ibrutinib)   C25H24N6O2 440.50 Btk Honigberg L.A. (2010) Proc Natl Acad Sci 107 13075-13080
PD 0325901   C16H14F3IN2O4 482.19 MEK1 Bain J. (2007) Biochem J. 408 297–315. Barrett SD. (2008) Bioorg. Med. Chem. Lett. 18 6501-6504.
PD 0325901-Cl (CI-1055-R)   C16H14O4N2F2ClI 498.65 MEK1
PD 0325901-Cl (CI-1055-Racemic mix of isomers)   C16H14O4N2F2ClI 498.65 MEK1
PD 0325901-Cl (CI-1055-S)   C16H14O4N2F2ClI 498.65 MEK1
PD 0332991   C24H30ClN7O2 483.99 CDK4, CDK6 Toogood P.L. (2005) J.Med.Chem. 48 2388-2406.