| Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
|---|---|---|---|---|---|---|---|
| OTSSP167 | C25H28Cl2N4O2 | 487.42 | 1431697-89-0 | 135398499 | MELK |
| Kinase | % Activity Remaining | Standard Deviation |
|---|---|---|
| ABL |
2
|
0 |
| AMPK |
2
|
0 |
| AMPK (hum) |
2
|
2 |
| ASK1 | 61 | 1 |
| Aurora A | 48 | 2 |
| Aurora B | 23 | 3 |
| BRK | 31 | 2 |
| BRSK1 | 14 | 4 |
| BRSK2 |
10
|
0 |
| BTK | 16 | 11 |
| CAMK1 | 48 | 3 |
| CAMKK beta |
4
|
1 |
| CDK2-Cyclin A |
6
|
1 |
| CDK9-Cyclin T1 | 11 | 10 |
| CHK1 | 34 | 1 |
| CHK2 |
1
|
0 |
| CK1 delta |
7
|
0 |
| CK1 gamma 2 | 26 | 1 |
| CK2 |
1
|
1 |
| CLK2 |
1
|
1 |
| CSK | 86 | 10 |
| DAPK1 |
1
|
0 |
| DDR2 |
1
|
0 |
| DYRK1A |
0
|
0 |
| DYRK2 |
1
|
0 |
| DYRK3 |
1
|
0 |
| EF2K | 99 | 19 |
| EIF2AK3 | 23 | 1 |
| EPH-A2 |
4
|
1 |
| EPH-A4 |
2
|
0 |
| EPH-B1 |
5
|
2 |
| EPH-B2 |
1
|
0 |
| EPH-B3 |
9
|
7 |
| EPH-B4 | 60 | 5 |
| ERK1 | 89 | 8 |
| ERK2 | 82 | 4 |
| ERK5 | 19 | 10 |
| ERK8 |
3
|
1 |
| FGF-R1 | 12 | 0 |
| GCK |
1
|
1 |
| GSK3 beta |
2
|
0 |
| HER4 | 16 | 0 |
| HIPK1 |
2
|
1 |
| HIPK2 |
4
|
4 |
| HIPK3 |
1
|
1 |
| IGF-1R |
8
|
3 |
| IKK beta | 76 | 3 |
| IKK epsilon | 18 | 18 |
| IR |
8
|
2 |
| IRAK1 |
9
|
1 |
| IRAK4 |
6
|
1 |
| IRR | 19 | 2 |
| JAK2 |
3
|
0 |
| JNK1 | 54 | 3 |
| JNK2 | 41 | 3 |
| JNK3 | 50 | 11 |
| Lck |
1
|
0 |
| LKB1 | 96 | 8 |
| MAP4K3 |
2
|
1 |
| MAP4K5 |
2
|
3 |
| MAPKAP-K2 | 36 | 2 |
| MAPKAP-K3 | 88 | 5 |
| MARK1 | 75 | 24 |
| MARK2 | 60 | 10 |
| MARK3 | 46 | 7 |
| MARK4 | 41 | 2 |
| MEKK1 | 91 | 5 |
| MELK |
5
|
3 |
| MINK1 |
3
|
0 |
| MKK1 |
8
|
1 |
| MKK2 | 15 | 1 |
| MKK6 | 104 | 11 |
| MLK1 |
3
|
1 |
| MLK3 |
2
|
1 |
| MNK1 | 76 | 16 |
| MNK2 | 49 | 13 |
| MPSK1 | 57 | 12 |
| MSK1 | 24 | 6 |
| MST2 |
3
|
2 |
| MST3 | 43 | 6 |
| MST4 | 19 | 2 |
| NEK2a | 84 | 13 |
| NEK6 | 89 | 6 |
| NUAK1 |
2
|
2 |
| OSR1 | 90 | 1 |
| p38 alpha MAPK | 38 | 0 |
| p38 beta MAPK | 18 | 6 |
| p38 delta MAPK | 19 | 2 |
| p38 gamma MAPK | 22 | 5 |
| PAK2 | 102 | 9 |
| PAK4 | 18 | 4 |
| PAK5 | 61 | 20 |
| PAK6 | 70 | 3 |
| PDGFRA |
4
|
1 |
| PDK1 | 14 | 1 |
| PHK |
1
|
1 |
| PIM1 |
4
|
2 |
| PIM2 |
1
|
2 |
| PIM3 |
1
|
0 |
| PINK | 92 | 2 |
| PKA | 42 | 8 |
| PKB alpha | 68 | 12 |
| PKB beta | 56 | 4 |
| PKC alpha |
10
|
1 |
| PKC gamma | 46 | 28 |
| PKC zeta | 50 | 6 |
| PKD1 | 18 | 12 |
| PLK1 | 16 | 2 |
| PRAK | 62 | 16 |
| PRK2 |
3
|
1 |
| RIPK2 |
3
|
1 |
| ROCK 2 | 60 | 2 |
| RSK1 |
2
|
0 |
| RSK2 |
4
|
0 |
| S6K1 |
6
|
1 |
| SGK1 | 27 | 5 |
| SIK2 |
6
|
2 |
| SIK3 | 12 | 0 |
| SmMLCK | 13 | 1 |
| Src |
9
|
6 |
| SRPK1 | 50 | 3 |
| STK33 | 12 | 1 |
| SYK | 35 | 1 |
| TAK1 |
0
|
1 |
| TAO1 |
3
|
0 |
| TBK1 | 11 | 0 |
| TESK1 | 75 | 16 |
| TGFBR1 | 73 | 0 |
| TIE2 | 20 | 9 |
| TLK1 | 91 | 28 |
| TrkA |
7
|
2 |
| TSSK1 |
5
|
0 |
| TTBK1 | 81 | 9 |
| TTBK2 | 96 | 13 |
| TTK |
6
|
1 |
| ULK1 | 52 | 0 |
| ULK2 | 14 | 1 |
| VEGFR1 |
2
|
1 |
| WNK1 | 110 | 6 |
| YES1 |
8
|
4 |
| ZAP70 | 126 | 2 |
| Kinase | % Activity Remaining | Standard Deviation |
|---|---|---|
| ABL |
1
|
0 |
| AMPK |
2
|
0 |
| AMPK (hum) |
1
|
0 |
| ASK1 |
7
|
2 |
| Aurora A |
10
|
1 |
| Aurora B | 14 | 1 |
| BRK |
8
|
3 |
| BRSK1 |
2
|
0 |
| BRSK2 |
2
|
2 |
| BTK |
7
|
3 |
| CAMK1 | 15 | 1 |
| CAMKK beta |
2
|
1 |
| CDK2-Cyclin A |
2
|
0 |
| CDK9-Cyclin T1 |
4
|
1 |
| CHK1 | 11 | 1 |
| CHK2 |
1
|
0 |
| CK1 delta |
6
|
5 |
| CK1 gamma 2 |
10
|
3 |
| CK2 |
1
|
0 |
| CLK2 |
0
|
0 |
| CSK |
9
|
6 |
| DAPK1 |
1
|
0 |
| DDR2 |
0
|
0 |
| DYRK1A |
1
|
0 |
| DYRK2 |
1
|
0 |
| DYRK3 |
1
|
1 |
| EF2K | 114 | 5 |
| EIF2AK3 |
7
|
0 |
| EPH-A2 |
7
|
0 |
| EPH-A4 |
1
|
1 |
| EPH-B1 | 11 | 2 |
| EPH-B2 |
1
|
1 |
| EPH-B3 | 18 | 7 |
| EPH-B4 |
2
|
0 |
| ERK1 | 88 | 1 |
| ERK2 | 90 | 5 |
| ERK5 |
4
|
1 |
| ERK8 |
1
|
1 |
| FGF-R1 |
4
|
1 |
| GCK |
0
|
0 |
| GSK3 beta |
0
|
0 |
| HER4 |
4
|
0 |
| HIPK1 |
0
|
0 |
| HIPK2 |
2
|
2 |
| HIPK3 |
0
|
0 |
| IGF-1R |
4
|
0 |
| IKK beta | 41 | 1 |
| IKK epsilon |
2
|
0 |
| IR |
2
|
0 |
| IRAK1 |
3
|
1 |
| IRAK4 |
7
|
1 |
| IRR |
6
|
2 |
| JAK2 |
3
|
1 |
| JNK1 |
10
|
1 |
| JNK2 | 16 | 1 |
| JNK3 | 13 | 1 |
| Lck |
0
|
0 |
| LKB1 | 83 | 8 |
| MAP4K3 |
1
|
0 |
| MAP4K5 |
3
|
1 |
| MAPKAP-K2 | 14 | 4 |
| MAPKAP-K3 | 94 | 0 |
| MARK1 | 31 | 1 |
| MARK2 | 23 | 1 |
| MARK3 | 13 | 3 |
| MARK4 | 14 | 0 |
| MEKK1 | 96 | 19 |
| MELK |
6
|
1 |
| MINK1 |
2
|
1 |
| MKK1 |
3
|
0 |
| MKK2 |
10
|
1 |
| MKK6 | 80 | 2 |
| MLK1 |
1
|
1 |
| MLK3 |
2
|
1 |
| MNK1 | 28 | 0 |
| MNK2 | 13 | 2 |
| MPSK1 |
5
|
0 |
| MSK1 |
5
|
0 |
| MST2 |
7
|
2 |
| MST3 |
5
|
0 |
| MST4 |
5
|
1 |
| NEK2a | 59 | 11 |
| NEK6 | 92 | 3 |
| NUAK1 |
0
|
2 |
| OSR1 | 45 | 3 |
| p38 alpha MAPK |
10
|
1 |
| p38 beta MAPK |
6
|
0 |
| p38 delta MAPK |
4
|
1 |
| p38 gamma MAPK | 12 | 5 |
| PAK2 | 74 | 10 |
| PAK4 |
9
|
2 |
| PAK5 | 19 | 1 |
| PAK6 | 29 | 3 |
| PDGFRA | 20 | 23 |
| PDK1 |
4
|
1 |
| PHK |
3
|
4 |
| PIM1 |
10
|
1 |
| PIM2 |
0
|
0 |
| PIM3 |
1
|
0 |
| PINK | 89 | 13 |
| PKA | 12 | 0 |
| PKB alpha | 28 | 1 |
| PKB beta | 24 | 2 |
| PKC alpha |
7
|
1 |
| PKC gamma |
1
|
0 |
| PKC zeta | 19 | 1 |
| PKD1 |
6
|
0 |
| PLK1 |
3
|
0 |
| PRAK | 16 | 0 |
| PRK2 |
2
|
0 |
| RIPK2 |
4
|
0 |
| ROCK 2 | 49 | 1 |
| RSK1 |
3
|
2 |
| RSK2 |
1
|
1 |
| S6K1 |
2
|
0 |
| SGK1 | 12 | 0 |
| SIK2 |
2
|
0 |
| SIK3 |
4
|
1 |
| SmMLCK |
6
|
3 |
| Src |
5
|
3 |
| SRPK1 |
10
|
1 |
| STK33 |
10
|
1 |
| SYK |
7
|
1 |
| TAK1 |
1
|
0 |
| TAO1 |
3
|
0 |
| TBK1 |
6
|
1 |
| TESK1 | 51 | 9 |
| TGFBR1 | 16 | 1 |
| TIE2 |
3
|
0 |
| TLK1 | 58 | 1 |
| TrkA |
1
|
2 |
| TSSK1 |
1
|
0 |
| TTBK1 | 82 | 6 |
| TTBK2 | 91 | 8 |
| TTK |
3
|
2 |
| ULK1 | 32 | 0 |
| ULK2 |
4
|
0 |
| VEGFR1 |
1
|
0 |
| WNK1 | 111 | 5 |
| YES1 | 18 | 9 |
| ZAP70 | 78 | 13 |