Inhibitor | OTSSP167  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
OTSSP167   C25H28Cl2N4O2 487.42 1431697-89-0 135398499 MELK

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ABL
2
 0
AMPK
2
 0
AMPK (hum)
2
 2
ASK1 61 1
Aurora A 48 2
Aurora B 23 3
BRK 31 2
BRSK1 14 4
BRSK2
10
 0
BTK 16 11
CAMK1 48 3
CAMKK beta
4
 1
CDK2-Cyclin A
6
 1
CDK9-Cyclin T1 11 10
CHK1 34 1
CHK2
1
 0
CK1 delta
7
 0
CK1 gamma 2 26 1
CK2
1
 1
CLK2
1
 1
CSK 86 10
DAPK1
1
 0
DDR2
1
 0
DYRK1A
0
 0
DYRK2
1
 0
DYRK3
1
 0
EF2K 99 19
EIF2AK3 23 1
EPH-A2
4
 1
EPH-A4
2
 0
EPH-B1
5
 2
EPH-B2
1
 0
EPH-B3
9
 7
EPH-B4 60 5
ERK1 89 8
ERK2 82 4
ERK5 19 10
ERK8
3
 1
FGF-R1 12 0
GCK
1
 1
GSK3 beta
2
 0
HER4 16 0
HIPK1
2
 1
HIPK2
4
 4
HIPK3
1
 1
IGF-1R
8
 3
IKK beta 76 3
IKK epsilon 18 18
IR
8
 2
IRAK1
9
 1
IRAK4
6
 1
IRR 19 2
JAK2
3
 0
JNK1 54 3
JNK2 41 3
JNK3 50 11
Lck
1
 0
LKB1 96 8
MAP4K3
2
 1
MAP4K5
2
 3
MAPKAP-K2 36 2
MAPKAP-K3 88 5
MARK1 75 24
MARK2 60 10
MARK3 46 7
MARK4 41 2
MEKK1 91 5
MELK
5
 3
MINK1
3
 0
MKK1
8
 1
MKK2 15 1
MKK6 104 11
MLK1
3
 1
MLK3
2
 1
MNK1 76 16
MNK2 49 13
MPSK1 57 12
MSK1 24 6
MST2
3
 2
MST3 43 6
MST4 19 2
NEK2a 84 13
NEK6 89 6
NUAK1
2
 2
OSR1 90 1
p38 alpha MAPK 38 0
p38 beta MAPK 18 6
p38 delta MAPK 19 2
p38 gamma MAPK 22 5
PAK2 102 9
PAK4 18 4
PAK5 61 20
PAK6 70 3
PDGFRA
4
 1
PDK1 14 1
PHK
1
 1
PIM1
4
 2
PIM2
1
 2
PIM3
1
 0
PINK 92 2
PKA 42 8
PKB alpha 68 12
PKB beta 56 4
PKC alpha
10
 1
PKC gamma 46 28
PKC zeta 50 6
PKD1 18 12
PLK1 16 2
PRAK 62 16
PRK2
3
 1
RIPK2
3
 1
ROCK 2 60 2
RSK1
2
 0
RSK2
4
 0
S6K1
6
 1
SGK1 27 5
SIK2
6
 2
SIK3 12 0
SmMLCK 13 1
Src
9
 6
SRPK1 50 3
STK33 12 1
SYK 35 1
TAK1
0
 1
TAO1
3
 0
TBK1 11 0
TESK1 75 16
TGFBR1 73 0
TIE2 20 9
TLK1 91 28
TrkA
7
 2
TSSK1
5
 0
TTBK1 81 9
TTBK2 96 13
TTK
6
 1
ULK1 52 0
ULK2 14 1
VEGFR1
2
 1
WNK1 110 6
YES1
8
 4
ZAP70 126 2
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL
1
 0
AMPK
2
 0
AMPK (hum)
1
 0
ASK1
7
 2
Aurora A
10
 1
Aurora B 14 1
BRK
8
 3
BRSK1
2
 0
BRSK2
2
 2
BTK
7
 3
CAMK1 15 1
CAMKK beta
2
 1
CDK2-Cyclin A
2
 0
CDK9-Cyclin T1
4
 1
CHK1 11 1
CHK2
1
 0
CK1 delta
6
 5
CK1 gamma 2
10
 3
CK2
1
 0
CLK2
0
 0
CSK
9
 6
DAPK1
1
 0
DDR2
0
 0
DYRK1A
1
 0
DYRK2
1
 0
DYRK3
1
 1
EF2K 114 5
EIF2AK3
7
 0
EPH-A2
7
 0
EPH-A4
1
 1
EPH-B1 11 2
EPH-B2
1
 1
EPH-B3 18 7
EPH-B4
2
 0
ERK1 88 1
ERK2 90 5
ERK5
4
 1
ERK8
1
 1
FGF-R1
4
 1
GCK
0
 0
GSK3 beta
0
 0
HER4
4
 0
HIPK1
0
 0
HIPK2
2
 2
HIPK3
0
 0
IGF-1R
4
 0
IKK beta 41 1
IKK epsilon
2
 0
IR
2
 0
IRAK1
3
 1
IRAK4
7
 1
IRR
6
 2
JAK2
3
 1
JNK1
10
 1
JNK2 16 1
JNK3 13 1
Lck
0
 0
LKB1 83 8
MAP4K3
1
 0
MAP4K5
3
 1
MAPKAP-K2 14 4
MAPKAP-K3 94 0
MARK1 31 1
MARK2 23 1
MARK3 13 3
MARK4 14 0
MEKK1 96 19
MELK
6
 1
MINK1
2
 1
MKK1
3
 0
MKK2
10
 1
MKK6 80 2
MLK1
1
 1
MLK3
2
 1
MNK1 28 0
MNK2 13 2
MPSK1
5
 0
MSK1
5
 0
MST2
7
 2
MST3
5
 0
MST4
5
 1
NEK2a 59 11
NEK6 92 3
NUAK1
0
 2
OSR1 45 3
p38 alpha MAPK
10
 1
p38 beta MAPK
6
 0
p38 delta MAPK
4
 1
p38 gamma MAPK 12 5
PAK2 74 10
PAK4
9
 2
PAK5 19 1
PAK6 29 3
PDGFRA 20 23
PDK1
4
 1
PHK
3
 4
PIM1
10
 1
PIM2
0
 0
PIM3
1
 0
PINK 89 13
PKA 12 0
PKB alpha 28 1
PKB beta 24 2
PKC alpha
7
 1
PKC gamma
1
 0
PKC zeta 19 1
PKD1
6
 0
PLK1
3
 0
PRAK 16 0
PRK2
2
 0
RIPK2
4
 0
ROCK 2 49 1
RSK1
3
 2
RSK2
1
 1
S6K1
2
 0
SGK1 12 0
SIK2
2
 0
SIK3
4
 1
SmMLCK
6
 3
Src
5
 3
SRPK1
10
 1
STK33
10
 1
SYK
7
 1
TAK1
1
 0
TAO1
3
 0
TBK1
6
 1
TESK1 51 9
TGFBR1 16 1
TIE2
3
 0
TLK1 58 1
TrkA
1
 2
TSSK1
1
 0
TTBK1 82 6
TTBK2 91 8
TTK
3
 2
ULK1 32 0
ULK2
4
 0
VEGFR1
1
 0
WNK1 111 5
YES1 18 9
ZAP70 78 13