Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
---|---|---|---|---|---|---|---|
PD 0325901-Cl (CI-1055-Racemic mix of isomers) | C16H14O4N2F2ClI | 498.65 | 391210-10-9 | MEK1 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 101 | 10 |
AMPK | 111 | 18 |
ASK1 | 102 | 13 |
Aurora A | 103 | 9 |
Aurora B | 99 | 2 |
BRK | 126 | 13 |
BRSK1 | 98 | 11 |
BRSK2 | 108 | 9 |
BTK | 102 | 9 |
CAMK1 | 106 | 1 |
CAMKK beta | 108 | 0 |
CDK2-Cyclin A | 95 | 7 |
CHK1 | 116 | 17 |
CHK2 | 104 | 2 |
CK1 delta | 96 | 5 |
CK2 | 111 | 8 |
CLK2 | 94 | 5 |
CSK | 89 | 16 |
DAPK1 | 97 | 6 |
DYRK1A | 91 | 3 |
DYRK2 | 107 | 13 |
DYRK3 | 107 | 0 |
EF2K | 84 | 7 |
EIF2AK3 | 103 | 25 |
EPH-A2 | 112 | 11 |
EPH-A4 | 97 | 5 |
EPH-B1 | 107 | 6 |
EPH-B2 | 100 | 20 |
EPH-B3 | 113 | 17 |
EPH-B4 | 98 | 5 |
ERK1 | 100 | 7 |
ERK2 | 83 | 8 |
ERK8 | 95 | 8 |
FGF-R1 | 110 | 28 |
GCK | 79 | 14 |
GSK3 beta | 89 | 9 |
HER4 | 86 | 4 |
HIPK1 | 96 | 5 |
HIPK2 | 102 | 7 |
HIPK3 | 90 | 2 |
IGF-1R | 76 | 1 |
IKK beta | 78 | 3 |
IKK epsilon | 102 | 9 |
IR | 93 | 28 |
IRAK1 | 81 | 1 |
IRAK4 | 77 | 5 |
IRR | 84 | 0 |
JAK2 |
5
|
1 |
JNK1 | 87 | 1 |
JNK2 | 88 | 0 |
JNK3 | 83 | 16 |
Lck | 93 | 8 |
LKB1 | 80 | 14 |
MAPKAP-K2 | 104 | 12 |
MAPKAP-K3 | 94 | 3 |
MARK1 | 77 | 1 |
MARK2 | 101 | 10 |
MARK3 | 73 | 9 |
MARK4 | 119 | 12 |
MEKK1 | 88 | 5 |
MELK | 109 | 11 |
MINK1 | 119 | 10 |
MKK1 | 36 | 14 |
MKK2 | 55 | 9 |
MKK6 | 90 | 2 |
MLK1 | 84 | 0 |
MLK3 | 83 | 18 |
MNK1 | 106 | 5 |
MNK2 | 89 | 7 |
MPSK1 | 87 | 10 |
MSK1 | 98 | 0 |
MST2 | 71 | 8 |
MST4 | 107 | 4 |
NEK2a | 98 | 4 |
NEK6 | 101 | 11 |
NUAK1 | 108 | 14 |
OSR1 | 87 | 22 |
p38 alpha MAPK | 102 | 7 |
p38 beta MAPK | 101 | 3 |
p38 delta MAPK | 84 | 3 |
p38 gamma MAPK | 80 | 3 |
PAK2 | 95 | 3 |
PAK4 | 98 | 4 |
PAK5 | 102 | 13 |
PAK6 | 98 | 21 |
PDK1 | 100 | 2 |
PHK | 94 | 2 |
PIM1 | 102 | 6 |
PIM2 | 91 | 13 |
PIM3 | 94 | 0 |
PKA | 94 | 7 |
PKB alpha | 99 | 21 |
PKB beta | 97 | 4 |
PKC alpha | 93 | 12 |
PKC gamma | 110 | 13 |
PKC zeta | 89 | 2 |
PKD1 | 91 | 4 |
PLK1 | 97 | 1 |
PRAK | 93 | 8 |
PRK2 | 70 | 1 |
RIPK2 | 86 | 7 |
ROCK 2 | 102 | 1 |
RSK1 | 122 | 7 |
RSK2 | 98 | 15 |
S6K1 | 94 | 4 |
SGK1 | 71 | 4 |
SmMLCK | 102 | 23 |
Src | 124 | 4 |
SRPK1 | 95 | 0 |
STK33 | 92 | 10 |
SYK | 73 | 46 |
TAK1 | 91 | 14 |
TAO1 | 92 | 25 |
TBK1 | 111 | 5 |
TIE2 | 106 | 7 |
TLK1 | 95 | 10 |
TrkA | 79 | 6 |
TTK | 105 | 3 |
VEGFR1 | 98 | 8 |
YES1 | 76 | 1 |
ZAP70 | 77 | 14 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 107 | 11 |
AMPK | 120 | 4 |
ASK1 | 112 | 14 |
Aurora A | 104 | 12 |
Aurora B | 78 | 0 |
BRK | 110 | 8 |
BRSK1 | 101 | 14 |
BRSK2 | 105 | 1 |
BTK | 97 | 9 |
CAMK1 | 84 | 2 |
CAMKK beta | 103 | 1 |
CDK2-Cyclin A | 97 | 2 |
CHK1 | 119 | 2 |
CHK2 | 93 | 10 |
CK1 delta | 97 | 2 |
CK2 | 98 | 13 |
CLK2 | 91 | 4 |
CSK | 88 | 13 |
DAPK1 | 98 | 17 |
DYRK1A | 85 | 8 |
DYRK2 | 111 | 5 |
DYRK3 | 83 | 19 |
EF2K | 92 | 1 |
EIF2AK3 | 90 | 28 |
EPH-A2 | 105 | 7 |
EPH-A4 | 100 | 4 |
EPH-B1 | 92 | 6 |
EPH-B2 | 77 | 2 |
EPH-B3 | 82 | 9 |
EPH-B4 | 86 | 3 |
ERK1 | 101 | 18 |
ERK2 | 79 | 6 |
ERK8 | 98 | 19 |
FGF-R1 | 99 | 37 |
GCK | 91 | 1 |
GSK3 beta | 89 | 3 |
HER4 | 82 | 6 |
HIPK1 | 85 | 9 |
HIPK2 | 106 | 1 |
HIPK3 | 101 | 6 |
IGF-1R | 98 | 8 |
IKK beta | 89 | 9 |
IKK epsilon | 103 | 11 |
IR | 97 | 28 |
IRAK1 | 79 | 2 |
IRAK4 | 91 | 11 |
IRR | 87 | 20 |
JAK2 |
8
|
1 |
JNK1 | 93 | 2 |
JNK2 | 92 | 8 |
JNK3 | 90 | 26 |
Lck | 104 | 11 |
LKB1 | 77 | 3 |
MAPKAP-K2 | 102 | 10 |
MAPKAP-K3 | 77 | 19 |
MARK1 | 71 | 4 |
MARK2 | 101 | 3 |
MARK3 | 88 | 5 |
MARK4 | 108 | 10 |
MEKK1 | 93 | 7 |
MELK | 106 | 4 |
MINK1 | 127 | 5 |
MKK1 |
3
|
1 |
MKK2 | 23 | 0 |
MKK6 | 67 | 6 |
MLK1 | 85 | 10 |
MLK3 | 89 | 4 |
MNK1 | 95 | 15 |
MNK2 | 90 | 5 |
MPSK1 | 86 | 16 |
MSK1 | 96 | 6 |
MST2 | 75 | 16 |
MST4 | 94 | 3 |
NEK2a | 94 | 6 |
NEK6 | 103 | 15 |
NUAK1 | 95 | 4 |
OSR1 | 87 | 5 |
p38 alpha MAPK | 97 | 0 |
p38 beta MAPK | 133 | 18 |
p38 delta MAPK | 97 | 7 |
p38 gamma MAPK | 96 | 3 |
PAK2 | 80 | 7 |
PAK4 | 77 | 14 |
PAK5 | 86 | 3 |
PAK6 | 103 | 2 |
PDK1 | 99 | 3 |
PHK | 90 | 5 |
PIM1 | 71 | 8 |
PIM2 | 93 | 8 |
PIM3 | 65 | 5 |
PKA | 103 | 3 |
PKB alpha | 99 | 4 |
PKB beta | 90 | 13 |
PKC alpha | 86 | 8 |
PKC gamma | 100 | 0 |
PKC zeta | 91 | 0 |
PKD1 | 87 | 8 |
PLK1 | 93 | 1 |
PRAK | 100 | 13 |
PRK2 | 79 | 13 |
RIPK2 | 84 | 8 |
ROCK 2 | 103 | 16 |
RSK1 | 98 | 3 |
RSK2 | 89 | 3 |
S6K1 | 80 | 17 |
SGK1 | 111 | 18 |
SmMLCK | 86 | 12 |
Src | 72 | 1 |
SRPK1 | 86 | 7 |
STK33 | 90 | 4 |
SYK | 77 | 9 |
TAK1 | 92 | 6 |
TAO1 | 99 | 25 |
TBK1 | 99 | 3 |
TIE2 | 87 | 5 |
TLK1 | 100 | 9 |
TrkA | 78 | 14 |
TTK | 98 | 2 |
VEGFR1 | 42 | 13 |
YES1 | 79 | 1 |
ZAP70 | 98 | 0 |