Inhibitor | PD 0332991  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
PD 0332991   C24H30ClN7O2 483.99 827022-32-2 5330286 CDK4, CDK6 Toogood P.L. (2005) J.Med.Chem. 48 2388-2406.

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 74 2
Aurora A 117 7
Aurora B 87 7
BRSK1 90 10
BRSK2 96 5
BTK 92 8
CAMK1 98 10
CAMKK beta 69 1
CDK2-Cyclin A 75 4
CHK1 88 2
CHK2 105 13
CK1 delta 82 3
CK2 55 4
CSK 106 7
DYRK1A 54 4
DYRK2 84 5
DYRK3 57 2
EF2K 105 5
EPH-A2 107 5
EPH-A4 101 10
EPH-B3 108 13
EPH-B4 111 2
ERK1 117 11
ERK2 99 3
ERK8 47 7
FGF-R1 120 5
GCK 72 21
GSK3 beta 103 4
HER4 111 8
HIPK1 101 4
HIPK2 28 1
HIPK3 83 0
IGF-1R 85 1
IKK beta 97 3
IKK epsilon 97 1
IR 110 1
IRAK4 98 3
IRR 52 1
JAK2 87 1
JNK1 84 10
JNK2 80 20
JNK3 100 8
Lck 91 48
LKB1 91 6
MAPKAP-K2 94 7
MAPKAP-K3 105 6
MARK1 99 13
MARK2 93 15
MARK3 95 9
MARK4 88 4
MEKK1 93 3
MELK 69 12
MINK1 89 3
MKK1 111 7
MLK1 100 6
MLK3 101 0
MNK1 97 6
MNK2 96 6
MSK1 98 0
MST2 113 4
MST4 101 6
NEK2a 109 2
NEK6 99 8
NUAK1 78 12
p38 alpha MAPK 97 7
p38 beta MAPK 96 4
p38 delta MAPK 89 11
p38 gamma MAPK 103 4
PAK2 97 3
PAK4 94 5
PAK5 91 3
PAK6 91 1
PDK1 102 1
PHK 71 10
PIM1 70 28
PIM2 104 4
PIM3 73 1
PKA 99 2
PKB alpha 92 12
PKB beta 84 0
PKC alpha 96 12
PKC zeta 99 2
PKD1 44 4
PLK1 49 8
PRAK 99 13
PRK2 89 1
RIPK2 99 18
ROCK 2 102 8
RSK1 85 0
RSK2 99 0
S6K1 98 23
SGK1 82 8
SmMLCK 94 7
Src 99 6
SRPK1 105 3
SYK 111 25
TAK1 76 1
TBK1 99 10
TrkA 66 2
TTK 61 0
VEGFR1 95 3
YES1 112 7
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 37 29
Aurora A 104 10
Aurora B 65 1
BRSK1 85 8
BRSK2 66 0
BTK 104 38
CAMK1 69 1
CAMKK beta 27 1
CDK2-Cyclin A 28 3
CHK1 59 1
CHK2 89 0
CK1 delta 72 10
CK2 13 4
CSK 112 3
DYRK1A
9
 1
DYRK2 44 6
DYRK3 16 9
EF2K 113 8
EPH-A2 97 2
EPH-A4 102 15
EPH-B3 98 6
EPH-B4 107 2
ERK1 90 10
ERK2 69 5
ERK8 13 1
FGF-R1 51 6
GCK 15 1
GSK3 beta 65 3
HER4 68 2
HIPK1 60 1
HIPK2
8
 2
HIPK3 35 11
IGF-1R 58 2
IKK beta 87 7
IKK epsilon 74 1
IR 67 2
IRAK4 67 12
IRR 30 0
JAK2 39 3
JNK1 71 2
JNK2 50 23
JNK3 61 3
Lck 55 20
LKB1 72 9
MAPKAP-K2 99 24
MAPKAP-K3 98 10
MARK1 79 3
MARK2 80 4
MARK3 67 0
MARK4 60 6
MEKK1 95 7
MELK 14 1
MINK1 41 2
MKK1 91 1
MLK1 63 1
MLK3 73 1
MNK1 101 0
MNK2 84 4
MSK1 85 2
MST2 99 8
MST4 135 3
NEK2a 70 6
NEK6 93 1
NUAK1 29 11
p38 alpha MAPK 108 9
p38 beta MAPK 103 6
p38 delta MAPK 91 1
p38 gamma MAPK 102 7
PAK2 93 7
PAK4 87 9
PAK5 71 1
PAK6 92 0
PDK1 102 9
PHK 22 2
PIM1 59 9
PIM2 62 3
PIM3 42 13
PKA 97 4
PKB alpha 96 9
PKB beta 74 1
PKC alpha 87 7
PKC zeta 93 3
PKD1 18 1
PLK1 18 3
PRAK 107 16
PRK2 87 9
RIPK2 113 39
ROCK 2 92 8
RSK1 30 1
RSK2 41 10
S6K1 82 4
SGK1 64 9
SmMLCK 35 1
Src 71 2
SRPK1 101 12
SYK 95 9
TAK1 21 0
TBK1 112 29
TrkA 18 0
TTK 84 44
VEGFR1 47 2
YES1 61 0