Inhibitor | NVP-BEZ 235  

Screen Conc: 0.01µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	99	12
Aurora B	97	6
BRSK2	89	16
BTK	107	9
CAMK1	119	1
CAMKK beta	84	0
CDK2-Cyclin A	93	7
CHK1	103	1
CHK2	101	14
CK1 delta	91	8
CK2	113	11
CSK	96	8
DYRK1A	92	11
DYRK2	110	7
DYRK3	96	7
EF2K	97	28
EPH-A2	132	16
EPH-B3	77	7
ERK1	89	4
ERK2	97	9
ERK8	96	0
FGF-R1	126	23
GSK3 beta	104	2
HIPK2	112	4
IGF-1R	109	17
IKK beta	101	4
IKK epsilon	106	13
IR	99	7
IRR	95	2
JNK1	99	4
JNK2	93	3
Lck	105	10
MAPKAP-K2	88	9
MARK3	89	1
MELK	94	5
MKK1	125	1
MNK1	94	5
MNK2	151	23
MSK1	107	6
MST2	87	0
MST4	108	11
NEK2a	101	3
NEK6	109	7
p38 alpha MAPK	89	4
p38 beta MAPK	90	9
p38 delta MAPK	105	2
p38 gamma MAPK	107	10
PAK4	94	6
PAK5	98	8
PAK6	104	8
PDK1	104	6
PHK	94	13
PIM1	98	2
PIM2	97	6
PIM3	112	11
PKA	98	4
PKB alpha	98	9
PKB beta	92	10
PKC alpha	116	3
PKC zeta	103	0
PKD1	85	0
PLK1	101	3
PRAK	100	11
PRK2	91	8
ROCK 2	102	2
RSK1	102	10
RSK2	114	11
S6K1	116	2
SGK1	103	0
SmMLCK	96	15
Src	95	2
SRPK1	113	0
SYK	82	24
TBK1	103	5
VEGFR1	103	0
YES1	113	3

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	98	1
Aurora B	86	9
BRSK2	85	14
BTK	101	0
CAMK1	120	11
CAMKK beta	70	7
CDK2-Cyclin A	73	9
CHK1	102	6
CHK2	97	18
CK1 delta	83	0
CK2	102	11
CSK	89	18
DYRK1A	92	6
DYRK2	101	9
DYRK3	76	5
EF2K	95	5
EPH-A2	119	5
EPH-B3	79	10
ERK1	88	9
ERK2	87	8
ERK8	88	0
FGF-R1	117	7
GSK3 beta	96	0
HIPK2	106	13
IGF-1R	81	22
IKK beta	98	3
IKK epsilon	101	6
IR	104	11
IRR	84	3
JNK1	98	1
JNK2	87	0
Lck	87	5
MAPKAP-K2	76	1
MARK3	87	7
MELK	60	0
MKK1	123	24
MNK1	96	11
MNK2	101	1
MSK1	97	4
MST2	76	6
MST4	102	9
NEK2a	88	3
NEK6	114	7
p38 alpha MAPK	83	2
p38 beta MAPK	86	2
p38 delta MAPK	111	0
p38 gamma MAPK	101	8
PAK4	89	7
PAK5	93	2
PAK6	108	6
PDK1	95	3
PHK	99	0
PIM1	92	0
PIM2	98	6
PIM3	104	8
PKA	92	7
PKB alpha	86	3
PKB beta	96	0
PKC alpha	119	14
PKC zeta	101	4
PKD1	91	14
PLK1	104	3
PRAK	88	6
PRK2	78	16
ROCK 2	102	4
RSK1	94	10
RSK2	116	21
S6K1	104	6
SGK1	96	0
SmMLCK	99	4
Src	81	4
SRPK1	116	3
SYK	89	7
TBK1	86	14
VEGFR1	121	13
YES1	108	0

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	90	0
Aurora B	85	6
BRSK2	99	9
BTK	98	5
CAMK1	127	8
CAMKK beta	53	3
CDK2-Cyclin A	71	11
CHK1	99	4
CHK2	107	15
CK1 delta	88	7
CK2	106	9
CSK	101	28
DYRK1A	84	2
DYRK2	90	5
DYRK3	59	4
EF2K	108	21
EPH-A2	111	4
EPH-B3	85	0
ERK1	98	3
ERK2	88	7
ERK8	74	4
FGF-R1	111	20
GSK3 beta	95	13
HIPK2	100	6
IGF-1R	75	18
IKK beta	98	3
IKK epsilon	107	14
IR	110	17
IRR	78	4
JNK1	103	10
JNK2	95	3
Lck	77	10
MAPKAP-K2	91	13
MARK3	111	3
MELK	35	0
MKK1	117	0
MNK1	93	10
MNK2	98	1
MSK1	104	2
MST2	48	4
MST4	97	15
NEK2a	96	9
NEK6	111	0
p38 alpha MAPK	85	5
p38 beta MAPK	99	5
p38 delta MAPK	112	5
p38 gamma MAPK	103	12
PAK4	92	2
PAK5	102	18
PAK6	105	1
PDK1	99	0
PHK	108	6
PIM1	91	16
PIM2	105	17
PIM3	88	19
PKA	96	9
PKB alpha	100	14
PKB beta	89	1
PKC alpha	105	11
PKC zeta	97	0
PKD1	81	2
PLK1	106	5
PRAK	88	6
PRK2	80	18
ROCK 2	102	9
RSK1	95	9
RSK2	133	4
S6K1	114	14
SGK1	111	16
SmMLCK	105	2
Src	82	10
SRPK1	116	1
SYK	98	9
TBK1	83	5
VEGFR1	95	2
YES1	115	20

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	92	3
Aurora B	93	3
BRSK2	90	7
BTK	66	21
CAMK1	108	13
CAMKK beta	45	6
CDK2-Cyclin A	59	1
CHK1	97	14
CHK2	79	0
CK1 delta	83	4
CK2	107	5
CSK	89	1
DYRK1A	50	5
DYRK2	76	5
DYRK3	51	7
EF2K	115	16
EPH-A2	96	6
EPH-B3	93	10
ERK1	89	3
ERK2	94	11
ERK8	60	6
FGF-R1	60	0
GSK3 beta	84	19
HIPK2	95	0
IGF-1R	73	12
IKK beta	98	9
IKK epsilon	94	9
IR	98	12
IRR	74	0
JNK1	94	6
JNK2	91	3
Lck	43	12
MAPKAP-K2	78	6
MARK3	104	11
MELK	41	2
MKK1	126	3
MNK1	94	6
MNK2	143	58
MSK1	95	4
MST2	45	1
MST4	98	4
NEK2a	98	22
NEK6	25	5
p38 alpha MAPK	87	1
p38 beta MAPK	85	3
p38 delta MAPK	104	4
p38 gamma MAPK	94	9
PAK4	91	8
PAK5	80	5
PAK6	114	6
PDK1	101	12
PHK	96	1
PIM1	60	6
PIM2	108	17
PIM3	88	21
PKA	98	4
PKB alpha	87	3
PKB beta	97	15
PKC alpha	88	0
PKC zeta	101	2
PKD1	79	1
PLK1	122	3
PRAK	72	10
PRK2	67	8
ROCK 2	97	2
RSK1	89	22
RSK2	93	9
S6K1	104	1
SGK1	107	9
SmMLCK	101	4
Src	89	13
SRPK1	97	3
SYK	62	40
TBK1	112	10
VEGFR1	117	18
YES1	85	2