Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
---|---|---|---|---|---|---|---|
Novartis 12a (PKD1) | C23H29F3N6O3 | 494.51 | PKD1 | Meredith E.L. (2010) J.Med.Chem. 53 5422-5438 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 102 | 11 |
AMPK | 97 | 17 |
ASK1 | 98 | 9 |
Aurora A | 92 | 7 |
Aurora B | 132 | 19 |
BRK | 114 | 1 |
BRSK1 | 96 | 15 |
BRSK2 | 67 | 8 |
BTK | 92 | 2 |
CAMK1 | 81 | 3 |
CAMKK beta | 85 | 17 |
CDK2-Cyclin A | 66 | 7 |
CHK1 | 115 | 34 |
CHK2 | 102 | 1 |
CK1 delta | 75 | 17 |
CK2 | 107 | 2 |
CLK2 | 78 | 8 |
CSK | 113 | 11 |
DAPK1 | 102 | 1 |
DYRK1A | 97 | 1 |
DYRK2 | 74 | 11 |
DYRK3 | 39 | 4 |
EF2K | 105 | 8 |
EIF2AK3 | 108 | 12 |
EPH-A2 | 78 | 13 |
EPH-A4 | 90 | 12 |
EPH-B1 | 96 | 8 |
EPH-B2 | 105 | 10 |
EPH-B3 | 105 | 3 |
EPH-B4 | 103 | 6 |
ERK1 | 78 | 10 |
ERK2 | 36 | 19 |
ERK8 | 63 | 7 |
FGF-R1 | 110 | 7 |
GCK | 41 | 4 |
GSK3 beta | 86 | 3 |
HER4 | 83 | 6 |
HIPK1 | 99 | 10 |
HIPK2 | 89 | 8 |
HIPK3 | 95 | 5 |
IGF-1R | 97 | 7 |
IKK beta | 85 | 1 |
IKK epsilon | 98 | 8 |
IR | 89 | 5 |
IRAK1 | 92 | 1 |
IRAK4 | 96 | 7 |
IRR | 100 | 13 |
JAK2 | 82 | 7 |
JNK1 | 109 | 15 |
JNK2 | 91 | 1 |
JNK3 | 88 | 13 |
Lck | 84 | 8 |
LKB1 | 77 | 2 |
MAPKAP-K2 | 99 | 14 |
MAPKAP-K3 | 92 | 1 |
MARK1 | 51 | 13 |
MARK2 | 97 | 11 |
MARK3 | 92 | 17 |
MARK4 | 87 | 4 |
MEKK1 | 115 | 8 |
MELK | 108 | 7 |
MINK1 | 65 | 4 |
MKK1 | 86 | 3 |
MKK2 | 106 | 4 |
MKK6 | 92 | 8 |
MLK1 | 81 | 25 |
MLK3 | 93 | 2 |
MNK1 | 95 | 9 |
MNK2 | 76 | 6 |
MPSK1 | 100 | 4 |
MSK1 | 97 | 11 |
MST2 | 103 | 4 |
MST4 | 117 | 2 |
NEK2a | 111 | 6 |
NEK6 | 86 | 10 |
NUAK1 | 59 | 22 |
OSR1 | 98 | 3 |
p38 alpha MAPK | 104 | 0 |
p38 beta MAPK | 99 | 0 |
p38 delta MAPK | 89 | 2 |
p38 gamma MAPK | 95 | 11 |
PAK2 | 105 | 10 |
PAK4 | 101 | 11 |
PAK5 | 97 | 0 |
PAK6 | 99 | 5 |
PDK1 | 94 | 13 |
PHK | 82 | 7 |
PIM1 | 114 | 5 |
PIM2 | 99 | 1 |
PIM3 | 97 | 1 |
PKA | 105 | 10 |
PKB alpha | 109 | 2 |
PKB beta | 97 | 14 |
PKC alpha | 97 | 19 |
PKC gamma | 106 | 2 |
PKC zeta | 88 | 8 |
PKD1 |
6
|
3 |
PLK1 | 101 | 9 |
PRAK | 109 | 3 |
PRK2 | 96 | 6 |
RIPK2 | 96 | 13 |
ROCK 2 | 99 | 4 |
RSK1 | 88 | 12 |
RSK2 | 98 | 8 |
S6K1 | 92 | 0 |
SGK1 | 63 | 64 |
SmMLCK | 85 | 14 |
Src | 106 | 8 |
SRPK1 | 105 | 10 |
STK33 | 103 | 16 |
SYK | 90 | 2 |
TAK1 | 94 | 2 |
TAO1 | 103 | 7 |
TBK1 | 100 | 20 |
TESK1 | 99 | 7 |
TIE2 | 101 | 4 |
TLK1 | 91 | 8 |
TrkA | 72 | 1 |
TSSK1 | 84 | 10 |
TTBK1 | 93 | 8 |
TTK | 111 | 14 |
VEGFR1 | 95 | 12 |
YES1 | 107 | 6 |
ZAP70 | 108 | 14 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 112 | 5 |
AMPK | 61 | 9 |
ASK1 | 84 | 3 |
Aurora A | 88 | 7 |
Aurora B | 117 | 0 |
BRK | 124 | 15 |
BRSK1 | 73 | 10 |
BRSK2 | 26 | 4 |
BTK | 120 | 4 |
CAMK1 | 20 | 5 |
CAMKK beta | 99 | 3 |
CDK2-Cyclin A | 30 | 5 |
CHK1 | 100 | 12 |
CHK2 | 106 | 16 |
CK1 delta | 42 | 6 |
CK2 | 110 | 19 |
CLK2 | 70 | 22 |
CSK | 116 | 3 |
DAPK1 | 93 | 16 |
DYRK1A | 63 | 7 |
DYRK2 | 29 | 2 |
DYRK3 | 14 | 12 |
EF2K | 111 | 11 |
EIF2AK3 | 101 | 2 |
EPH-A2 | 99 | 1 |
EPH-A4 | 78 | 4 |
EPH-B1 | 111 | 7 |
EPH-B2 | 129 | 26 |
EPH-B3 | 124 | 15 |
EPH-B4 | 84 | 23 |
ERK1 | 34 | 3 |
ERK2 | 29 | 1 |
ERK8 | 26 | 2 |
FGF-R1 | 85 | 13 |
GCK | 82 | 6 |
GSK3 beta | 82 | 14 |
HER4 | 99 | 23 |
HIPK1 | 99 | 1 |
HIPK2 | 125 | 1 |
HIPK3 | 92 | 1 |
IGF-1R | 102 | 12 |
IKK beta | 50 | 1 |
IKK epsilon | 87 | 13 |
IR | 86 | 5 |
IRAK1 | 102 | 21 |
IRAK4 | 127 | 16 |
IRR | 107 | 6 |
JAK2 | 87 | 4 |
JNK1 | 100 | 8 |
JNK2 | 94 | 32 |
JNK3 | 79 | 8 |
Lck | 30 | 7 |
LKB1 | 96 | 24 |
MAPKAP-K2 | 72 | 12 |
MAPKAP-K3 | 100 | 16 |
MARK1 | 94 | 19 |
MARK2 | 63 | 4 |
MARK3 | 40 | 7 |
MARK4 | 46 | 9 |
MEKK1 | 114 | 27 |
MELK | 78 | 17 |
MINK1 | 13 | 1 |
MKK1 | 77 | 18 |
MKK2 | 123 | 2 |
MKK6 | 29 | 6 |
MLK1 | 69 | 3 |
MLK3 | 86 | 10 |
MNK1 | 38 | 3 |
MNK2 | 31 | 2 |
MPSK1 | 93 | 6 |
MSK1 | 109 | 12 |
MST2 | 110 | 1 |
MST4 | 107 | 4 |
NEK2a | 129 | 8 |
NEK6 | 87 | 8 |
NUAK1 | 17 | 5 |
OSR1 | 104 | 6 |
p38 alpha MAPK | 116 | 13 |
p38 beta MAPK | 96 | 7 |
p38 delta MAPK | 93 | 7 |
p38 gamma MAPK | 96 | 5 |
PAK2 | 93 | 1 |
PAK4 | 93 | 6 |
PAK5 | 90 | 1 |
PAK6 | 99 | 7 |
PDK1 | 114 | 28 |
PHK | 29 | 1 |
PIM1 | 98 | 14 |
PIM2 | 102 | 5 |
PIM3 | 58 | 1 |
PKA | 109 | 8 |
PKB alpha | 106 | 8 |
PKB beta | 57 | 11 |
PKC alpha | 95 | 15 |
PKC gamma | 103 | 7 |
PKC zeta | 109 | 3 |
PKD1 |
5
|
2 |
PLK1 | 117 | 3 |
PRAK | 97 | 1 |
PRK2 | 66 | 3 |
RIPK2 | 96 | 3 |
ROCK 2 | 108 | 26 |
RSK1 | 53 | 9 |
RSK2 | 110 | 22 |
S6K1 | 96 | 1 |
SGK1 | 104 | 25 |
SmMLCK | 40 | 4 |
Src | 90 | 7 |
SRPK1 | 86 | 5 |
STK33 | 83 | 22 |
SYK | 104 | 6 |
TAK1 | 100 | 5 |
TAO1 | 113 | 22 |
TBK1 | 88 | 9 |
TESK1 | 102 | 3 |
TIE2 | 111 | 9 |
TLK1 | 107 | 9 |
TrkA | 68 | 22 |
TSSK1 | 56 | 1 |
TTBK1 | 128 | 28 |
TTK | 87 | 0 |
VEGFR1 | 88 | 13 |
YES1 | 94 | 6 |
ZAP70 | 114 | 17 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 100 | 5 |
AMPK | 20 | 3 |
ASK1 | 21 | 5 |
Aurora A | 112 | 8 |
Aurora B | 115 | 14 |
BRK | 103 | 2 |
BRSK1 | 26 | 1 |
BRSK2 |
8
|
2 |
BTK | 79 | 10 |
CAMK1 |
1
|
0 |
CAMKK beta | 62 | 17 |
CDK2-Cyclin A | 11 | 2 |
CHK1 | 70 | 1 |
CHK2 | 88 | 10 |
CK1 delta | 18 | 2 |
CK2 | 65 | 1 |
CLK2 | 51 | 8 |
CSK | 90 | 11 |
DAPK1 | 40 | 10 |
DYRK1A | 21 | 2 |
DYRK2 |
10
|
5 |
DYRK3 |
7
|
5 |
EF2K | 87 | 5 |
EIF2AK3 | 97 | 1 |
EPH-A2 | 82 | 10 |
EPH-A4 | 48 | 9 |
EPH-B1 | 99 | 1 |
EPH-B2 | 113 | 29 |
EPH-B3 | 94 | 5 |
EPH-B4 | 91 | 3 |
ERK1 |
10
|
2 |
ERK2 |
6
|
2 |
ERK8 |
4
|
2 |
FGF-R1 | 82 | 1 |
GCK | 44 | 1 |
GSK3 beta | 51 | 7 |
HER4 | 73 | 0 |
HIPK1 | 106 | 2 |
HIPK2 | 87 | 14 |
HIPK3 | 101 | 11 |
IGF-1R | 99 | 14 |
IKK beta | 23 | 4 |
IKK epsilon | 48 | 9 |
IR | 93 | 11 |
IRAK1 | 87 | 3 |
IRAK4 | 92 | 4 |
IRR | 97 | 9 |
JAK2 | 89 | 6 |
JNK1 | 38 | 18 |
JNK2 | 35 | 4 |
JNK3 | 31 | 4 |
Lck |
9
|
1 |
LKB1 | 71 | 6 |
MAPKAP-K2 | 22 | 1 |
MAPKAP-K3 | 92 | 12 |
MARK1 | 76 | 9 |
MARK2 | 31 | 4 |
MARK3 | 15 | 4 |
MARK4 |
10
|
4 |
MEKK1 | 102 | 13 |
MELK | 40 | 8 |
MINK1 |
2
|
1 |
MKK1 | 49 | 1 |
MKK2 | 115 | 2 |
MKK6 | 16 | 3 |
MLK1 | 103 | 12 |
MLK3 | 81 | 4 |
MNK1 |
7
|
5 |
MNK2 |
6
|
2 |
MPSK1 | 84 | 12 |
MSK1 | 79 | 3 |
MST2 | 98 | 0 |
MST4 | 95 | 1 |
NEK2a | 113 | 1 |
NEK6 | 42 | 5 |
NUAK1 | 32 | 4 |
OSR1 | 73 | 6 |
p38 alpha MAPK | 103 | 3 |
p38 beta MAPK | 62 | 9 |
p38 delta MAPK | 50 | 1 |
p38 gamma MAPK | 58 | 2 |
PAK2 | 57 | 3 |
PAK4 | 74 | 3 |
PAK5 | 71 | 4 |
PAK6 | 81 | 9 |
PDK1 | 107 | 14 |
PHK |
5
|
1 |
PIM1 | 65 | 7 |
PIM2 | 99 | 8 |
PIM3 | 42 | 4 |
PKA | 93 | 14 |
PKB alpha | 94 | 11 |
PKB beta |
3
|
1 |
PKC alpha | 90 | 0 |
PKC gamma | 115 | 10 |
PKC zeta | 84 | 10 |
PKD1 |
5
|
0 |
PLK1 | 111 | 1 |
PRAK | 65 | 11 |
PRK2 | 19 | 1 |
RIPK2 | 79 | 1 |
ROCK 2 | 51 | 1 |
RSK1 |
2
|
2 |
RSK2 | 81 | 1 |
S6K1 | 94 | 8 |
SGK1 | 90 | 13 |
SmMLCK |
10
|
5 |
Src | 66 | 14 |
SRPK1 | 46 | 5 |
STK33 | 66 | 0 |
SYK | 92 | 10 |
TAK1 | 55 | 1 |
TAO1 | 53 | 2 |
TBK1 | 30 | 1 |
TESK1 | 93 | 9 |
TIE2 | 84 | 4 |
TLK1 | 90 | 11 |
TrkA | 71 | 4 |
TSSK1 | 12 | 3 |
TTBK1 | 93 | 5 |
TTK | 79 | 7 |
VEGFR1 | 68 | 1 |
YES1 | 76 | 12 |
ZAP70 | 109 | 1 |