Inhibitor | PCI-32765 (Ibrutinib)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
PCI-32765 (Ibrutinib)   C25H24N6O2 440.50 936563-96-1 24821094 Btk Honigberg L.A. (2010) Proc Natl Acad Sci 107 13075-13080

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ABL 87 13
AMPK 88 4
ASK1 103 1
Aurora A 92 0
Aurora B 96 13
BRK
10
 3
BRSK1 81 23
BRSK2 100 9
BTK 55 3
CAMK1 80 13
CAMKK beta 86 5
CDK2-Cyclin A 89 5
CHK1 76 9
CHK2 92 8
CK1 delta 98 5
CK2 104 15
CLK2 96 15
CSK 25 6
DAPK1 95 4
DYRK1A 112 8
DYRK2 83 1
DYRK3 93 8
EF2K 88 0
EIF2AK3 110 13
EPH-A2 91 10
EPH-A4 97 20
EPH-B1 72 4
EPH-B2 102 10
EPH-B3 99 3
EPH-B4 83 9
ERK1 83 8
ERK2 94 7
ERK8 85 3
FGF-R1 52 8
GCK 98 5
GSK3 beta 104 17
HER4
7
 0
HIPK1 75 4
HIPK2 91 11
HIPK3 100 12
IGF-1R 95 0
IKK beta 94 4
IKK epsilon 100 4
IR 77 3
IRAK1 108 7
IRAK4 103 12
IRR 94 3
JAK2 90 2
JNK1 98 6
JNK2 89 9
JNK3 84 7
Lck 22 1
LKB1 106 5
MAPKAP-K2 88 5
MAPKAP-K3 109 5
MARK1 101 14
MARK2 88 11
MARK3 98 11
MARK4 111 1
MEKK1 106 6
MELK 69 5
MINK1 90 0
MKK1 85 2
MKK2 94 1
MKK6 82 0
MLK1 104 7
MLK3 87 0
MNK1 91 17
MNK2 106 9
MPSK1 99 2
MSK1 94 6
MST2 88 3
MST4 100 10
NEK2a 93 6
NEK6 76 11
NUAK1 99 10
OSR1 96 1
p38 alpha MAPK 99 1
p38 beta MAPK 94 20
p38 delta MAPK 88 9
p38 gamma MAPK 89 9
PAK2 87 1
PAK4 93 10
PAK5 93 13
PAK6 95 3
PDK1 93 8
PHK 116 34
PIM1 98 2
PIM2 99 1
PIM3 94 4
PKA 89 1
PKB alpha 79 10
PKB beta 80 4
PKC alpha 99 8
PKC gamma 85 0
PKC zeta 90 10
PKD1 64 16
PLK1 88 13
PRAK 101 8
PRK2 109 9
RIPK2 21 1
ROCK 2 93 3
RSK1 94 12
RSK2 103 6
S6K1 93 4
SGK1 95 7
SmMLCK 79 1
Src 37 4
SRPK1 100 9
STK33 97 2
SYK 90 7
TAK1 102 10
TAO1 113 5
TBK1 102 3
TESK1 69 9
TIE2 71 10
TLK1 96 12
TrkA 64 9
TSSK1 105 2
TTBK1 78 5
TTK 95 1
VEGFR1 40 3
YES1 20 0
ZAP70 93 16
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 80 1
AMPK 101 7
ASK1 128 1
Aurora A 57 2
Aurora B 61 7
BRK
4
 1
BRSK1 80 28
BRSK2 91 2
BTK 55 1
CAMK1 99 12
CAMKK beta 109 5
CDK2-Cyclin A 99 10
CHK1 93 9
CHK2 77 6
CK1 delta 111 8
CK2 115 7
CLK2 95 9
CSK 15 13
DAPK1 95 15
DYRK1A 105 8
DYRK2 105 9
DYRK3 86 14
EF2K 102 21
EIF2AK3 81 5
EPH-A2 98 9
EPH-A4 92 13
EPH-B1 90 9
EPH-B2 65 0
EPH-B3 96 5
EPH-B4 74 0
ERK1 93 21
ERK2 99 0
ERK8 98 6
FGF-R1 24 1
GCK 77 6
GSK3 beta 95 6
HER4
8
 1
HIPK1 87 2
HIPK2 91 14
HIPK3 123 4
IGF-1R 93 1
IKK beta 107 6
IKK epsilon 95 19
IR 99 10
IRAK1 115 3
IRAK4 102 9
IRR 101 0
JAK2 103 2
JNK1 98 7
JNK2 101 3
JNK3 96 5
Lck 14 2
LKB1 134 43
MAPKAP-K2 95 9
MAPKAP-K3 109 0
MARK1 103 12
MARK2 102 6
MARK3 94 3
MARK4 114 5
MEKK1 103 17
MELK 105 37
MINK1 91 4
MKK1 76 3
MKK2 94 6
MKK6 97 1
MLK1 89 5
MLK3 65 5
MNK1 115 14
MNK2 82 21
MPSK1 117 9
MSK1 101 6
MST2 65 2
MST4 73 4
NEK2a 107 12
NEK6 99 9
NUAK1 82 8
OSR1 96 4
p38 alpha MAPK 103 3
p38 beta MAPK 103 8
p38 delta MAPK 104 14
p38 gamma MAPK 112 1
PAK2 72 4
PAK4 85 9
PAK5 97 2
PAK6 97 3
PDK1 124 14
PHK 104 10
PIM1 95 1
PIM2 100 17
PIM3 96 12
PKA 101 0
PKB alpha 97 1
PKB beta 93 7
PKC alpha 106 21
PKC gamma 104 14
PKC zeta 98 1
PKD1 69 7
PLK1 95 3
PRAK 107 6
PRK2 100 9
RIPK2
5
 0
ROCK 2 111 3
RSK1 101 6
RSK2 106 19
S6K1 86 8
SGK1 107 0
SmMLCK 90 1
Src 13 1
SRPK1 115 8
STK33 84 10
SYK 100 4
TAK1 106 13
TAO1 119 1
TBK1 113 4
TESK1 71 14
TIE2 34 4
TLK1 99 2
TrkA 46 1
TSSK1 108 4
TTBK1 100 9
TTK 101 3
VEGFR1
7
 1
YES1 16 0
ZAP70 107 5
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
ABL 39 2
AMPK 78 1
ASK1 111 6
Aurora A
10
 1
Aurora B 13 1
BRK
8
 5
BRSK1 49 11
BRSK2 61 12
BTK 42 4
CAMK1 33 8
CAMKK beta 80 3
CDK2-Cyclin A 84 6
CHK1 77 0
CHK2 35 9
CK1 delta 115 15
CK2 111 10
CLK2 71 10
CSK
3
 0
DAPK1 84 5
DYRK1A 87 1
DYRK2 79 2
DYRK3 68 5
EF2K 90 6
EIF2AK3 28 2
EPH-A2 64 5
EPH-A4 45 1
EPH-B1 86 2
EPH-B2 11 1
EPH-B3 51 2
EPH-B4 39 0
ERK1 84 7
ERK2 90 12
ERK8 74 1
FGF-R1 15 2
GCK 38 0
GSK3 beta 75 9
HER4
5
 1
HIPK1 75 14
HIPK2 66 2
HIPK3 110 8
IGF-1R 63 19
IKK beta 90 12
IKK epsilon 66 15
IR 31 11
IRAK1 98 32
IRAK4 86 3
IRR 29 5
JAK2 83 13
JNK1 75 1
JNK2 123 29
JNK3 86 2
Lck
9
 3
LKB1 100 0
MAPKAP-K2 90 1
MAPKAP-K3 75 20
MARK1 88 11
MARK2 82 7
MARK3 76 14
MARK4 80 6
MEKK1 56 4
MELK 56 18
MINK1 57 3
MKK1 56 3
MKK2 63 2
MKK6 61 12
MLK1 27 18
MLK3 28 5
MNK1 84 6
MNK2 67 4
MPSK1 104 7
MSK1 55 6
MST2 41 9
MST4 27 6
NEK2a 35 2
NEK6 93 12
NUAK1 26 13
OSR1 82 9
p38 alpha MAPK 101 8
p38 beta MAPK 68 4
p38 delta MAPK 80 3
p38 gamma MAPK 88 10
PAK2 55 4
PAK4 42 6
PAK5 50 3
PAK6 82 3
PDK1 102 14
PHK 92 7
PIM1 81 3
PIM2 97 15
PIM3 88 4
PKA 97 11
PKB alpha 78 1
PKB beta 71 4
PKC alpha 100 12
PKC gamma 99 5
PKC zeta 81 3
PKD1 30 6
PLK1 76 3
PRAK 83 11
PRK2 90 2
RIPK2
2
 0
ROCK 2 69 6
RSK1 46 5
RSK2 68 7
S6K1 66 1
SGK1 84 1
SmMLCK 44 6
Src
6
 4
SRPK1 99 0
STK33 113 101
SYK 52 6
TAK1 66 4
TAO1 84 1
TBK1 90 7
TESK1 38 8
TIE2
9
 1
TLK1 96 6
TrkA 13 7
TSSK1 68 5
TTBK1 81 11
TTK 82 9
VEGFR1
2
 1
YES1 13 0
ZAP70 101 10