Inhibitor | Parthenolide  

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	119	1
AMPK	97	5
AMPK (hum)	111	5
ASK1	98	16
Aurora A	134	21
Aurora B	106	5
BRK	107	4
BRSK1	109	3
BRSK2	109	13
BTK	117	12
CAMK1	116	17
CAMKK beta	96	24
CDK2-Cyclin A	93	6
CDK9-Cyclin T1	119	12
CHK1	123	10
CHK2	102	19
CK1 delta	99	3
CK1 gamma 2	124	11
CK2	117	7
CLK2	90	5
CSK	130	23
DAPK1	102	2
DDR2	105	4
DYRK1A	120	7
DYRK2	113	5
DYRK3	124	1
EF2K	107	7
EIF2AK3	111	9
EPH-A2	104	4
EPH-A4	110	3
EPH-B1	103	4
EPH-B2	72	4
EPH-B3	95	6
EPH-B4	124	2
ERK1	105	8
ERK2	90	9
ERK8	98	4
FGF-R1	106	1
GCK	116	3
GSK3 beta	106	13
HER4	98	17
HIPK1	114	1
HIPK2	124	13
HIPK3	110	12
IGF-1R	120	8
IKK beta	94	20
IKK epsilon	112	3
IR	117	22
IRAK1	96	1
IRAK4	106	10
IRR	107	1
JAK2	116	0
JNK1	104	3
JNK2	114	5
JNK3	115	1
Lck	112	3
LKB1	132	12
MAP4K3	95	3
MAP4K5	116	10
MAPKAP-K2	72	19
MAPKAP-K3	135	18
MARK1	100	12
MARK2	112	2
MARK3	123	0
MARK4	111	9
MEKK1	112	6
MELK	138	9
MINK1	108	3
MKK1	96	5
MKK2	114	35
MKK6	96	10
MLK1	117	11
MLK3	104	5
MNK1	116	1
MNK2	113	6
MPSK1	121	16
MSK1	110	3
MST2	118	1
MST3	101	12
MST4	88	7
NEK2a	110	11
NEK6	113	7
NUAK1	130	1
OSR1	115	5
p38 alpha MAPK	105	3
p38 beta MAPK	111	0
p38 delta MAPK	115	12
p38 gamma MAPK	108	3
PAK2	102	14
PAK4	93	11
PAK5	117	2
PAK6	119	7
PDGFRA	105	36
PDK1	114	12
PHK	116	3
PIM1	97	4
PIM2	110	3
PIM3	119	7
PKA	121	4
PKB alpha	107	15
PKB beta	101	15
PKC alpha	108	2
PKC gamma	120	9
PKC zeta	117	10
PKD1	130	12
PLK1	103	6
PRAK	131	27
PRK2	106	0
RIPK2	101	2
ROCK 2	123	3
RSK1	110	9
RSK2	102	5
S6K1	103	8
SGK1	127	20
SIK2	108	3
SIK3	110	6
SmMLCK	123	9
Src	110	0
SRPK1	111	2
STK33	117	5
SYK	102	11
TAK1	109	2
TAO1	118	21
TBK1	104	7
TESK1	106	10
TIE2	99	9
TLK1	108	4
TrkA	106	8
TSSK1	103	4
TTBK1	110	8
TTBK2	125	10
TTK	109	9
ULK1	104	0
ULK2	96	5
VEGFR1	109	2
WNK1	112	2
YES1	125	31
ZAP70	99	5

Screen Conc: 5.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	110	1
AMPK	98	1
AMPK (hum)	107	4
ASK1	125	13
Aurora A	115	13
Aurora B	99	11
BRK	120	12
BRSK1	108	5
BRSK2	89	20
BTK	85	9
CAMK1	104	1
CAMKK beta	84	32
CDK2-Cyclin A	116	12
CDK9-Cyclin T1	101	17
CHK1	98	1
CHK2	121	7
CK1 delta	92	21
CK1 gamma 2	101	8
CK2	106	15
CLK2	93	2
CSK	98	2
DAPK1	107	13
DDR2	107	5
DYRK1A	101	9
DYRK2	101	2
DYRK3	106	1
EF2K	91	15
EIF2AK3	123	6
EPH-A2	99	1
EPH-A4	87	4
EPH-B1	115	6
EPH-B2	78	6
EPH-B3	115	2
EPH-B4	114	20
ERK1	103	4
ERK2	83	19
ERK8	119	12
FGF-R1	99	13
GCK	98	12
GSK3 beta	105	11
HER4	90	11
HIPK1	106	16
HIPK2	113	10
HIPK3	122	6
IGF-1R	109	10
IKK beta	69	31
IKK epsilon	108	9
IR	106	30
IRAK1	102	11
IRAK4	97	5
IRR	95	3
JAK2	98	3
JNK1	102	10
JNK2	110	2
JNK3	134	8
Lck	114	21
LKB1	106	3
MAP4K3	88	8
MAP4K5	97	4
MAPKAP-K2	64	11
MAPKAP-K3	58	11
MARK1	94	8
MARK2	102	6
MARK3	98	14
MARK4	93	5
MEKK1	120	0
MELK	100	3
MINK1	122	11
MKK1	93	1
MKK2	109	1
MKK6	92	12
MLK1	95	5
MLK3	116	7
MNK1	94	1
MNK2	117	5
MPSK1	106	5
MSK1	106	13
MST2	125	14
MST3	88	7
MST4	94	17
NEK2a	122	23
NEK6	82	2
NUAK1	111	3
OSR1	118	25
p38 alpha MAPK	111	18
p38 beta MAPK	121	7
p38 delta MAPK	113	13
p38 gamma MAPK	115	7
PAK2	103	6
PAK4	104	2
PAK5	98	7
PAK6	115	14
PDGFRA	109	1
PDK1	98	3
PHK	108	2
PIM1	108	6
PIM2	102	7
PIM3	121	7
PKA	103	2
PKB alpha	106	12
PKB beta	92	8
PKC alpha	108	12
PKC gamma	121	4
PKC zeta	98	2
PKD1	108	10
PLK1	103	2
PRAK	112	22
PRK2	102	9
RIPK2	112	4
ROCK 2	113	1
RSK1	112	1
RSK2	94	0
S6K1	106	2
SGK1	115	12
SIK2	93	12
SIK3	104	7
SmMLCK	113	4
Src	111	2
SRPK1	106	10
STK33	102	4
SYK	105	3
TAK1	116	22
TAO1	103	7
TBK1	132	32
TESK1	112	10
TIE2	80	9
TLK1	115	8
TrkA	83	3
TSSK1	93	7
TTBK1	103	2
TTBK2	100	12
TTK	106	3
ULK1	110	5
ULK2	121	1
VEGFR1	98	5
WNK1	100	5
YES1	109	9
ZAP70	104	3