Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
SYK Inhibitor IV (BAY 61-3606)   C20H18N6O3 • HCl • H2O 444.90 SYK Yamamoto N. (2003) J Pharmacol Exp Ther 306 1174


0.20 85
VX-745   C19H9Cl2F2N3OS 436.26 p38 MAPK Tsai YR Epub 2013 Jan 21 Eur J Pharmacol. 2013 Feb 15 701(1-3) 96-105

WO1998027098
10.00 81
2-Aminopurine   C5H5N5 135.13 PKR

100.00 80
Amgen-NIK-28   C20H20N4O 332.40 NIK Li K. (2013) Bioorganic and Medicinal Chemistry Letters 23 1238-1244


0.10 109
Amgen-NIK-28   C20H20N4O 332.40 NIK Li K. (2013) Bioorganic and Medicinal Chemistry Letters 23 1238-1244


1.00 71
Amlexanox   C16H14N2O4 298.29 TBK1, IKKe

10.00 55
Amlexanox   C16H14N2O4 298.29 TBK1, IKKe

1.00 89
BAY 61-3606 C20H18N6O3 · xHCl · yH2O 390.40 Syk Yamamoto N. (2003) J. Pharmacol. Exp. Ther. 306 1174-1181


1.00 89
BAY 61-3606 C20H18N6O3 · xHCl · yH2O 390.40 Syk Yamamoto N. (2003) J. Pharmacol. Exp. Ther. 306 1174-1181


10.00 59
BX-912   C20H23BrN8O 471.35 PDK Feldman RI. (2005) J. Biol. Chem. 2005 May 20 280(20) 19867-74


0.10 28