Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
TTT-3002 LRRK2 Yao C (2012) Hum Mol Genet.


1.00 1
TTT-3002 LRRK2 Yao C (2012) Hum Mol Genet.


0.10 2
Ubiquitin E1 Inhibitor (PYR-41)   C17H13N3O7 • 3H2O 425.40 Ubiquitin-E1 Yang Y (2007) Cancer Res. 67 9472


10.00 108
Uo126   C18H16N6S2 380.48 MEK1, MEK2 Favata (1998) J. Biol. Chem. 273 18623
Duncia (1998) Bioorg. Med. Chem. Lett. 8 2839

10.00 76
UCN-01   C28H26N4O4 482.50 PKC Reinhardt H.C. (2007) Cancer Cell 11 175
Jiang X. (2004) Mol. Cancer Ther. 3 1221

0.01 8
Uo126   C18H16N6S2 380.48 MEK1, MEK2 Favata (1998) J. Biol. Chem. 273 18623
Duncia (1998) Bioorg. Med. Chem. Lett. 8 2839

5.00 58
VX-680   C23H28N8OS 464.59 Aurora Harrington E.A. (2004) Nature Medicine 10 262


1.00 80
VX-680   C23H28N8OS 464.59 Aurora Harrington E.A. (2004) Nature Medicine 10 262


10.00 68
VX-745   C19H9Cl2F2N3OS 436.26 p38 MAPK Tsai YR Epub 2013 Jan 21 Eur J Pharmacol. 2013 Feb 15 701(1-3) 96-105

WO1998027098
1.00 97
VX-745   C19H9Cl2F2N3OS 436.26 p38 MAPK Tsai YR Epub 2013 Jan 21 Eur J Pharmacol. 2013 Feb 15 701(1-3) 96-105

WO1998027098
0.10 100