Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Genentech LRRK2 inhibitor compound 19   C20H21F4N5O3 455.41 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33


 1.00 82
Genentech LRRK2 inhibitor compound 19   C20H21F4N5O3 455.41 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33


 10.00 44
GSK2606414   C24H20F3N5O 451.44 PERK Axten JM. (2012) J. Med. Chem. 23 55(16) 7193-207


 1.00 1
GSK2606414   C24H20F3N5O 451.44 PERK Axten JM. (2012) J. Med. Chem. 23 55(16) 7193-207


 0.10 75
H-89, Dihydrochloride   C20H20BrN3O2S • 2HCl 519.30 PKA Leemhuis J. (2002) J. Pharmacol. Exp. Ther. 300 1000
Davies S.P. (2000) Biochem. J. 351 95
WO2003080649
 10.00 14
H-89, Dihydrochloride   C20H20BrN3O2S • 2HCl 519.30 PKA Leemhuis J. (2002) J. Pharmacol. Exp. Ther. 300 1000
Davies S.P. (2000) Biochem. J. 351 95
WO2003080649
 1.00 70
HG-10-102-01 LRRK2 Choi H.G. (2012) ACS Med. Chem. Lett.


 10.00 71
HG-10-102-01 LRRK2 Choi H.G. (2012) ACS Med. Chem. Lett.


 1.00 91
IRAK 1-4 Inhibitor 1   C20H21N5O4 395.41 IRAK1, IRAK4 Powers J. P. (2006) Bioorg. Med. Chem. Lett. 16 2842-2845


 1.00 115
IRAK 1-4 Inhibitor 1   C20H21N5O4 395.41 IRAK1, IRAK4 Powers J. P. (2006) Bioorg. Med. Chem. Lett. 16 2842-2845


 10.00 107