Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
SYK Inhibitor IV (BAY 61-3606)   C20H18N6O3 • HCl • H2O 444.90 SYK Yamamoto N. (2003) J Pharmacol Exp Ther 306 1174


 1.00 96
SYK Inhibitor IV (BAY 61-3606)   C20H18N6O3 • HCl • H2O 444.90 SYK Yamamoto N. (2003) J Pharmacol Exp Ther 306 1174


 0.10 100
SYK Inhibitor IV (BAY 61-3606)   C20H18N6O3 • HCl • H2O 444.90 SYK Yamamoto N. (2003) J Pharmacol Exp Ther 306 1174


 10.00 93
TAE684 C30H40ClN7O3S 614.22 NPM-ALK Zhang J. (2012) Bioorg. Med. Chem. Lett. 22 1864–1869
Galkin A.V. (2007) Proc. Natl. Acad. Sci. USA 104 (1) 270-275

10.00 34
TAE684 C30H40ClN7O3S 614.22 NPM-ALK Zhang J. (2012) Bioorg. Med. Chem. Lett. 22 1864–1869
Galkin A.V. (2007) Proc. Natl. Acad. Sci. USA 104 (1) 270-275

1.00 27
TG003   C13H15NO2S 249.33 Cdc2-like kinase Muraki M. (2004) J. Biol. Chem. 279 24246-24254


 10.00 92
TG003   C13H15NO2S 249.33 Cdc2-like kinase Muraki M. (2004) J. Biol. Chem. 279 24246-24254


 1.00 114
Torin1 C35H28F3N5O2 607.62 mTOR Liu Q. (2012) J Biol Chem. 287 9742-52


 10.00 93
Torin1 C35H28F3N5O2 607.62 mTOR Liu Q. (2012) J Biol Chem. 287 9742-52


 1.00 78
TTT-3002 LRRK2 Yao C (2012) Hum Mol Genet.


 0.01 6