Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
HG-10-102-01 LRRK2 Choi H.G. (2012) ACS Med. Chem. Lett.


 10.00 90
HG-10-102-01 LRRK2 Choi H.G. (2012) ACS Med. Chem. Lett.


 1.00 80
HG-9-91-01   C32H38ClN7O3 604.14 SIK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91


 0.10 11
HG-9-91-01   C32H38ClN7O3 604.14 SIK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91


 0.01 34
HG-9-91-01   C32H38ClN7O3 604.14 SIK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91


 1.00 8
Hypothemycin C19H22O8 378.37 cyclin D1 H. Sonoda (1999) Life Sci. 65 381
A. Zhao (1999) J. Antibiot. 52 1086

0.10 85
Hypothemycin C19H22O8 378.37 cyclin D1 H. Sonoda (1999) Life Sci. 65 381
A. Zhao (1999) J. Antibiot. 52 1086

1.00 81
Hypothemycin C19H22O8 378.37 cyclin D1 H. Sonoda (1999) Life Sci. 65 381
A. Zhao (1999) J. Antibiot. 52 1086

0.01 87
IKK Inhibitor VII   C28H29N5OS 483.60 IKK Waelchli R. (2006) Bioorg. Med. Chem. Lett. 16 108


 10.00 19
IKK Inhibitor VII   C28H29N5OS 483.60 IKK Waelchli R. (2006) Bioorg. Med. Chem. Lett. 16 108


 1.00 25