Inhibitor | GSK2606414  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
GSK2606414   C24H20F3N5O 451.44 53469448 PERK Axten JM. (2012) J. Med. Chem. 23 55(16) 7193-207

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ABL 86 11
AMPK (hum) 75 0
ASK1 98 9
Aurora A 105 10
Aurora B 34 1
BRK 42 9
BRSK1 81 3
BRSK2 88 2
BTK 97 9
CAMK1 91 6
CAMKK beta 99 8
CDK2-Cyclin A 85 7
CDK9-Cyclin T1 99 11
CHK1 87 19
CHK2 88 10
CK1 delta 108 2
CK1 gamma 2 129 3
CK2 104 2
CLK2 76 4
CSK 87 13
DAPK1 97 11
DDR2 85 5
DYRK1A 95 3
DYRK2 102 10
DYRK3 106 5
EF2K 97 8
EIF2AK3
3
 1
EPH-A2 86 4
EPH-A4 113 3
EPH-B1 90 0
EPH-B2 108 1
EPH-B3 93 5
EPH-B4 96 9
ERK1 90 11
ERK2 107 17
ERK5 106 11
ERK8 90 1
FGF-R1 87 9
GCK 66 4
GSK3 beta 102 2
HER4 106 4
HIPK1 100 1
HIPK2 93 17
HIPK3 107 4
IGF-1R 83 9
IKK beta 110 17
IKK epsilon 15 6
IR 82 1
IRAK1 106 1
IRAK4 109 6
IRR 85 4
JAK2 64 6
JNK1 101 1
JNK2 100 10
JNK3 94 5
Lck 78 0
LKB1 96 16
MAP4K3 63 3
MAP4K5 52 12
MAPKAP-K2 97 18
MAPKAP-K3 111 2
MARK1 72 11
MARK2 65 3
MARK3 101 9
MARK4 73 13
MEKK1 87 5
MELK 72 5
MINK1 99 11
MKK1 82 1
MKK2 59 3
MKK6 97 7
MLK1 23 2
MLK3 31 6
MNK1 96 11
MNK2 98 12
MPSK1 89 16
MSK1 101 11
MST2 70 7
MST3 88 9
MST4 108 7
NEK2a 89 2
NEK6 103 5
NUAK1 105 3
OSR1 103 18
p38 alpha MAPK 92 16
p38 beta MAPK 97 4
p38 delta MAPK 85 5
p38 gamma MAPK 107 22
PAK2 99 1
PAK4 87 3
PAK5 97 1
PAK6 112 1
PDGFRA 19 2
PDK1 82 14
PHK 104 1
PIM1 95 5
PIM2 103 7
PIM3 107 6
PINK 103 4
PKA 98 12
PKB alpha 93 10
PKB beta 104 3
PKC alpha 105 13
PKC gamma 77 0
PKC zeta 96 1
PKD1 105 4
PKR 20 1
PLK1 100 18
PRAK 83 4
PRK2 87 6
RIPK2 101 2
ROCK 2 86 9
RSK1 79 1
RSK2 72 4
S6K1 104 7
SGK1 105 1
SIK2 52 3
SIK3 66 13
SmMLCK 99 7
Src 82 30
SRPK1 99 11
STK33 75 3
SYK 105 14
TAK1 102 3
TAO1 102 11
TBK1 85 8
TESK1 73 12
TGFBR1 90 18
TIE2 51 10
TLK1 92 7
TrkA 37 5
TSSK1 18 1
TTBK1 98 14
TTBK2 120 7
TTK 103 8
ULK1 109 15
ULK2 77 9
VEGFR1 61 5
WNK1 106 3
YES1 92 1
ZAP70 93 2
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 51 2
AMPK (hum)
1
 0
ASK1 84 17
Aurora A 52 12
Aurora B
6
 0
BRK
10
 3
BRSK1 76 9
BRSK2 21 7
BTK 55 5
CAMK1 51 2
CAMKK beta 89 3
CDK2-Cyclin A 13 1
CDK9-Cyclin T1 72 3
CHK1
8
 1
CHK2 49 6
CK1 delta 90 1
CK1 gamma 2 102 15
CK2 113 1
CLK2 37 1
CSK 56 7
DAPK1 33 0
DDR2 30 6
DYRK1A 55 5
DYRK2 86 1
DYRK3 82 9
EF2K 108 26
EIF2AK3
1
 0
EPH-A2 69 11
EPH-A4 65 8
EPH-B1 57 9
EPH-B2 77 1
EPH-B3 54 4
EPH-B4 71 3
ERK1 103 4
ERK2 113 1
ERK5 72 3
ERK8 61 6
FGF-R1 53 3
GCK
5
 0
GSK3 beta 91 10
HER4 98 12
HIPK1 83 4
HIPK2 56 16
HIPK3 102 15
IGF-1R 78 7
IKK beta 104 19
IKK epsilon
2
 1
IR 62 17
IRAK1 79 8
IRAK4 29 3
IRR 74 0
JAK2
4
 2
JNK1 102 2
JNK2 86 4
JNK3 91 6
Lck 22 3
LKB1 106 6
MAP4K3
2
 0
MAP4K5
3
 1
MAPKAP-K2 81 0
MAPKAP-K3 107 3
MARK1
5
 0
MARK2
2
 0
MARK3
1
 0
MARK4
3
 1
MEKK1 95 4
MELK 12 2
MINK1 15 3
MKK1
4
 0
MKK2
6
 1
MKK6 70 4
MLK1
3
 0
MLK3
5
 1
MNK1 101 6
MNK2 75 4
MPSK1 105 13
MSK1 38 2
MST2
3
 0
MST3 84 4
MST4 52 13
NEK2a 56 1
NEK6 84 4
NUAK1
10
 2
OSR1 54 1
p38 alpha MAPK 101 15
p38 beta MAPK 88 2
p38 delta MAPK 35 4
p38 gamma MAPK 89 27
PAK2 94 6
PAK4 22 1
PAK5 26 4
PAK6 53 7
PDGFRA
5
 0
PDK1
2
 0
PHK 59 12
PIM1 58 2
PIM2 91 5
PIM3 100 10
PINK 102 12
PKA 25 1
PKB alpha 54 0
PKB beta 61 2
PKC alpha 50 8
PKC gamma 57 2
PKC zeta 89 0
PKD1 37 4
PKR
9
 0
PLK1 106 12
PRAK 88 2
PRK2
7
 1
RIPK2 75 6
ROCK 2 28 5
RSK1
1
 0
RSK2
2
 1
S6K1
10
 2
SGK1 65 0
SIK2
2
 0
SIK3
4
 0
SmMLCK 91 9
Src 24 1
SRPK1 106 1
STK33 42 5
SYK
7
 1
TAK1 40 6
TAO1 16 0
TBK1 13 4
TESK1 42 0
TGFBR1 97 1
TIE2 11 2
TLK1 32 3
TrkA
3
 2
TSSK1
2
 0
TTBK1 107 7
TTBK2 118 2
TTK 56 12
ULK1 59 1
ULK2 16 1
VEGFR1
6
 1
WNK1 77 16
YES1 45 9
ZAP70 71 5