Inhibitor | GSK461364  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
GSK461364   C27H28F3N5O2S 543.60 929095-18-1 15983966 PLK1 T. R. Rheault (2010) Bioorg. Med. Chem. Lett. 20(15) 4587-92 K. A. Emmitte (2009) Bioorg. Med. Chem. Lett. 19(6) 1694-7

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ABL 100 5
AMPK 92 2
ASK1 115 15
Aurora A 106 11
Aurora B 80 8
BRK 118 16
BRSK1 86 4
BRSK2 88 9
BTK 100 9
CAMK1 95 4
CAMKK beta 95 5
CDK2-Cyclin A 97 12
CDK9-Cyclin T1 88 3
CHK1 94 9
CHK2 88 5
CK1 delta 94 4
CK1 gamma 2 79 13
CK2 90 5
CLK2 89 13
CSK 86 7
DAPK1 81 0
DDR2 118 6
DYRK1A 98 7
DYRK2 99 3
DYRK3 90 2
EF2K 95 7
EIF2AK3 90 32
EPH-A2 85 2
EPH-A4 122 1
EPH-B1 101 3
EPH-B2 110 2
EPH-B3 114 4
EPH-B4 108 1
ERK1 100 5
ERK2 94 8
ERK8 98 10
FGF-R1 117 14
GCK 97 6
GSK3 beta 87 16
HER4 95 9
HIPK1 98 11
HIPK2 100 4
HIPK3 122 7
IGF-1R 86 3
IKK beta 92 12
IKK epsilon 89 3
IR 77 1
IRAK1 102 2
IRAK4 83 10
IRR 94 3
JAK2 105 8
JNK1 94 4
JNK2 103 19
JNK3 98 10
Lck 106 4
LKB1 95 7
MAPKAP-K2 83 2
MAPKAP-K3 85 2
MARK1 82 1
MARK2 88 11
MARK3 80 3
MARK4 92 7
MEKK1 96 7
MELK 97 5
MINK1 79 13
MKK1 80 6
MKK2 87 10
MKK6 102 22
MLK1 84 3
MLK3 91 1
MNK1 100 24
MNK2 94 6
MPSK1 96 5
MSK1 95 5
MST2 91 5
MST3 86 12
MST4 86 1
NEK2a 66 6
NEK6 96 0
NUAK1 75 7
OSR1 103 18
p38 alpha MAPK 90 5
p38 beta MAPK 97 4
p38 delta MAPK 96 9
p38 gamma MAPK 94 2
PAK2 83 1
PAK4 107 4
PAK5 97 3
PAK6 98 6
PDK1 96 1
PHK 89 8
PIM1 77 3
PIM2 101 12
PIM3 81 2
PKA 99 8
PKB alpha 101 11
PKB beta 96 4
PKC alpha 112 8
PKC gamma 108 17
PKC zeta 120 7
PKD1 96 11
PLK1
6
 2
PRAK 99 8
PRK2 52 4
RIPK2 87 5
ROCK 2 98 10
RSK1 76 3
RSK2 87 21
S6K1 93 10
SGK1 100 6
SIK2 86 11
SIK3 95 14
SmMLCK 93 1
Src 85 3
SRPK1 93 12
STK33 93 5
SYK 122 6
TAK1 88 5
TAO1 96 5
TBK1 109 1
TESK1 97 16
TIE2 93 2
TLK1 118 6
TrkA 103 0
TSSK1 81 7
TTBK1 99 2
TTK 100 3
VEGFR1 97 2
WNK1 97 4
YES1 120 21
ZAP70 103 5
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 91 4
AMPK 80 3
ASK1 102 9
Aurora A 104 3
Aurora B 75 0
BRK 113 24
BRSK1 37 5
BRSK2 41 5
BTK 85 8
CAMK1 95 3
CAMKK beta 89 5
CDK2-Cyclin A 87 9
CDK9-Cyclin T1 76 8
CHK1 97 11
CHK2 73 4
CK1 delta 88 7
CK1 gamma 2 104 2
CK2 104 10
CLK2 82 5
CSK 93 9
DAPK1 79 19
DDR2 111 10
DYRK1A 91 1
DYRK2 90 5
DYRK3 98 13
EF2K 89 2
EIF2AK3 112 17
EPH-A2 78 1
EPH-A4 92 5
EPH-B1 103 10
EPH-B2 130 7
EPH-B3 105 7
EPH-B4 122 13
ERK1 86 18
ERK2 91 12
ERK8 71 9
FGF-R1 89 31
GCK 84 15
GSK3 beta 83 8
HER4 98 0
HIPK1 93 3
HIPK2 85 4
HIPK3 118 5
IGF-1R 110 5
IKK beta 93 7
IKK epsilon 101 14
IR 78 1
IRAK1 99 8
IRAK4 84 4
IRR 92 6
JAK2 99 8
JNK1 90 1
JNK2 93 1
JNK3 89 11
Lck 93 0
LKB1 97 8
MAPKAP-K2 81 1
MAPKAP-K3 95 10
MARK1 95 3
MARK2 99 1
MARK3 82 10
MARK4 84 12
MEKK1 57 1
MELK 86 21
MINK1 72 4
MKK1 81 3
MKK2 98 10
MKK6 80 6
MLK1 45 2
MLK3 63 2
MNK1 101 28
MNK2 89 5
MPSK1 94 4
MSK1 83 7
MST2 88 2
MST3 98 3
MST4 114 7
NEK2a 21 4
NEK6 91 10
NUAK1 35 3
OSR1 103 11
p38 alpha MAPK 87 7
p38 beta MAPK 99 1
p38 delta MAPK 100 1
p38 gamma MAPK 94 8
PAK2 81 8
PAK4 88 3
PAK5 83 2
PAK6 96 13
PDK1 105 5
PHK 98 2
PIM1 33 2
PIM2 99 2
PIM3 43 2
PKA 99 6
PKB alpha 93 1
PKB beta 90 12
PKC alpha 109 15
PKC gamma 102 11
PKC zeta 109 14
PKD1 79 15
PLK1
5
 0
PRAK 100 1
PRK2 15 2
RIPK2 65 3
ROCK 2 81 8
RSK1 35 3
RSK2 51 17
S6K1 94 3
SGK1 100 2
SIK2 92 2
SIK3 73 2
SmMLCK 82 3
Src 78 3
SRPK1 81 5
STK33 87 6
SYK 112 12
TAK1 87 8
TAO1 92 20
TBK1 96 7
TESK1 90 7
TIE2 68 2
TLK1 110 7
TrkA 86 11
TSSK1 50 9
TTBK1 88 9
TTK 96 1
VEGFR1 83 4
WNK1 85 3
YES1 102 20
ZAP70 97 0