Inhibitor | Dasatinib  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Dasatinib   C22H26ClN7O2S 487.00 302962-49-8 3062316 BCR-ABL, Src, Multiple Tyrosine kinases targeted Kantarjian H. N Engl J Med. (2010) 2260-70

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ABL
0
 0
AMPK (hum) 107 13
ASK1 108 7
Aurora A 94 0
Aurora B 120 10
BRK
5
 0
BRSK1 126 0
BRSK2 102 14
BTK
1
 0
CAMK1 89 16
CAMKK beta 96 4
CDK2-Cyclin A 116 1
CDK9-Cyclin T1 122 8
CHK1 100 6
CHK2 98 8
CK1 delta 113 4
CK1 gamma 2 115 0
CK2 95 3
CLK2 120 6
CSK 97 19
DAPK1 126 10
DDR2
1
 1
DYRK1A 111 4
DYRK2 101 5
DYRK3 98 7
EF2K 104 4
EIF2AK3 106 6
EPH-A2
1
 0
EPH-A4
2
 0
EPH-B1
-1
 1
EPH-B2
1
 0
EPH-B3
1
 0
EPH-B4 20 0
ERK1 91 6
ERK2 93 9
ERK5 87 2
ERK8 90 14
FGF-R1 88 7
GCK 95 7
GSK3 beta 103 2
HER4 27 1
HIPK1 105 4
HIPK2 95 1
HIPK3 102 3
IGF-1R 107 6
IKK beta 97 21
IKK epsilon 102 5
IR 99 2
IRAK1 96 1
IRAK4 112 24
IRR 89 4
JAK2 94 2
JNK1 108 4
JNK2 110 10
JNK3 108 0
Lck
1
 0
LKB1 96 18
MAP4K3 88 15
MAP4K5 22 1
MAPKAP-K2 114 4
MAPKAP-K3 117 3
MARK1 115 3
MARK2 118 4
MARK3 96 16
MARK4 105 12
MEKK1 98 4
MELK 112 7
MINK1 90 4
MKK1 118 10
MKK2 113 11
MKK6 104 11
MLK1 72 1
MLK3 76 10
MNK1 108 0
MNK2 97 8
MPSK1 101 5
MSK1 94 4
MST2 75 2
MST3 114 20
MST4 97 10
NEK2a 122 11
NEK6 113 4
NUAK1 119 10
OSR1 100 1
p38 alpha MAPK 79 15
p38 beta MAPK 105 11
p38 delta MAPK 118 17
p38 gamma MAPK 100 4
PAK2 118 2
PAK4 137 21
PAK5 131 12
PAK6 126 9
PDGFRA
6
 1
PDK1 94 9
PHK 101 10
PIM1 90 1
PIM2 104 3
PIM3 96 8
PINK 117 1
PKA 110 12
PKB alpha 103 15
PKB beta 94 11
PKC alpha 98 3
PKC gamma 107 22
PKC zeta 101 3
PKD1 92 21
PLK1 133 18
PRAK 129 14
PRK2 100 2
RIPK2
5
 0
ROCK 2 130 10
RSK1 105 2
RSK2 86 9
S6K1 108 3
SGK1 87 11
SIK2
4
 1
SIK3
9
 2
SmMLCK 111 4
Src
1
 0
SRPK1 104 9
STK33 105 6
SYK 97 1
TAK1 97 23
TAO1 120 9
TBK1 100 1
TESK1 50 3
TGFBR1 103 1
TIE2 88 7
TLK1 96 4
TrkA 107 11
TSSK1 106 11
TTBK1 112 8
TTBK2 110 5
TTK 104 6
ULK1 95 9
ULK2 101 3
VEGFR1 78 9
WNK1 104 4
YES1
1
 0
ZAP70 109 1
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL
0
 0
AMPK (hum) 120 5
ASK1 118 7
Aurora A 101 1
Aurora B 108 10
BRK
2
 0
BRSK1 123 1
BRSK2 108 13
BTK
1
 0
CAMK1 77 1
CAMKK beta 99 19
CDK2-Cyclin A 112 1
CDK9-Cyclin T1 138 12
CHK1 96 6
CHK2 102 1
CK1 delta 124 1
CK1 gamma 2 113 12
CK2 80 28
CLK2 121 6
CSK
8
 3
DAPK1 102 7
DDR2
0
 0
DYRK1A 126 19
DYRK2 117 9
DYRK3 104 9
EF2K 95 5
EIF2AK3 113 2
EPH-A2
1
 0
EPH-A4
2
 2
EPH-B1
-1
 2
EPH-B2
1
 0
EPH-B3
1
 0
EPH-B4
3
 0
ERK1 114 12
ERK2 102 1
ERK5 91 4
ERK8 95 11
FGF-R1 84 6
GCK 56 8
GSK3 beta 121 12
HER4
6
 0
HIPK1 122 6
HIPK2 97 5
HIPK3 113 7
IGF-1R 98 7
IKK beta 99 9
IKK epsilon 123 13
IR 94 7
IRAK1 108 3
IRAK4 102 6
IRR 90 14
JAK2 42 1
JNK1 121 9
JNK2 125 0
JNK3 113 15
Lck
1
 0
LKB1 100 14
MAP4K3 54 1
MAP4K5
3
 1
MAPKAP-K2 111 7
MAPKAP-K3 132 1
MARK1 127 3
MARK2 126 2
MARK3 104 5
MARK4 115 24
MEKK1 102 1
MELK 128 7
MINK1 51 1
MKK1 134 16
MKK2 91 0
MKK6 112 4
MLK1 41 2
MLK3 39 6
MNK1 102 9
MNK2 106 2
MPSK1 123 1
MSK1 103 1
MST2 81 6
MST3 93 2
MST4 77 4
NEK2a 98 4
NEK6 123 6
NUAK1 118 8
OSR1 101 0
p38 alpha MAPK 29 2
p38 beta MAPK 44 4
p38 delta MAPK 133 1
p38 gamma MAPK 105 7
PAK2 119 12
PAK4 132 16
PAK5 138 7
PAK6 120 4
PDGFRA
3
 1
PDK1 92 1
PHK 103 1
PIM1 98 1
PIM2 105 1
PIM3 108 5
PINK 133 5
PKA 121 27
PKB alpha 120 13
PKB beta 94 2
PKC alpha 105 14
PKC gamma 114 22
PKC zeta 109 7
PKD1 107 15
PLK1 99 15
PRAK 128 7
PRK2 101 0
RIPK2
10
 12
ROCK 2 132 7
RSK1 102 5
RSK2 101 3
S6K1 113 11
SGK1 96 7
SIK2
2
 1
SIK3
2
 0
SmMLCK 111 7
Src
2
 0
SRPK1 107 9
STK33 110 4
SYK 90 0
TAK1 99 7
TAO1 95 7
TBK1 97 10
TESK1
8
 0
TGFBR1 82 5
TIE2 78 5
TLK1 124 0
TrkA 88 2
TSSK1 113 3
TTBK1 112 1
TTBK2 117 7
TTK 109 9
ULK1 101 0
ULK2 91 3
VEGFR1 53 4
WNK1 104 12
YES1
1
 0
ZAP70 121 27