Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
BI605906 (BIX02514)   C17H22F2N4O3S2 432.51 IKKβ Clark K. (2011) Biochem. J. 434 93-104


1.00 89
BIO (6-Bromoindirubin-3'-oxime)   C16H10BrN3O2 356.20 GSK3 Tseng A.S. (2006) Chem. Biol. 13 957
Polychronopoulos P. (2004) J. Med. Chem. 47 935
WO2007016485
0.10 41
BIO (6-Bromoindirubin-3'-oxime)   C16H10BrN3O2 356.20 GSK3 Tseng A.S. (2006) Chem. Biol. 13 957
Polychronopoulos P. (2004) J. Med. Chem. 47 935
WO2007016485
10.00 4
BIO (6-Bromoindirubin-3'-oxime)   C16H10BrN3O2 356.20 GSK3 Tseng A.S. (2006) Chem. Biol. 13 957
Polychronopoulos P. (2004) J. Med. Chem. 47 935
WO2007016485
0.01 76
BIO (6-Bromoindirubin-3'-oxime)   C16H10BrN3O2 356.20 GSK3 Tseng A.S. (2006) Chem. Biol. 13 957
Polychronopoulos P. (2004) J. Med. Chem. 47 935
WO2007016485
1.00 4
BIRB-0796 (Doramapimod)   C31H37N5O3 527.66 p38 MAPK Regan J. (2002) J. Med. Chem 45 2994-3008

WO2004014387
0.10 94
BIRB-0796 (Doramapimod)   C31H37N5O3 527.66 p38 MAPK Regan J. (2002) J. Med. Chem 45 2994-3008

WO2004014387
1.00 73
Blebbistatin   C18H16N2O2 292.30 myosin II Shu S. (2005) Proc. Natl. Acad. Sci. USA 102 1472
Kovacs M. (2004) J. Biol. Chem. 279 35557
WO2012062819
10.00 96
BML-258 (SK1-I)   C17H28ClNO2 313.86 SphK1 Paugh S.W. (2008) Blood 112 1382-1391


1.00 100
BML-258 (SK1-I)   C17H28ClNO2 313.86 SphK1 Paugh S.W. (2008) Blood 112 1382-1391


0.10 123