Inhibitor | CAY10576  

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	98	5
AMPK	94	1
AMPK (hum)	87	4
ASK1	109	14
Aurora A	102	3
Aurora B	100	6
BRK	79	2
BRSK1	113	0
BRSK2	114	11
BTK	99	18
CAMK1	107	3
CAMKK beta	97	1
CDK2-Cyclin A	90	7
CDK9-Cyclin T1	107	18
CHK1	102	12
CHK2	90	2
CK1 delta	97	10
CK1 gamma 2	102	3
CK2	103	6
CLK2	96	8
CSK	98	2
DAPK1	96	0
DDR2	103	14
DYRK1A	110	6
DYRK2	106	1
DYRK3	98	13
EF2K	94	3
EIF2AK3	106	5
EPH-A2	106	11
EPH-A4	104	1
EPH-B1	99	6
EPH-B2	119	17
EPH-B3	81	3
EPH-B4	99	18
ERK1	92	0
ERK2	84	3
ERK5	98	2
ERK8	90	6
FGF-R1	80	1
GCK	95	7
GSK3 beta	102	4
HER4	100	11
HIPK1	71	3
HIPK2	108	15
HIPK3	79	14
IGF-1R	89	9
IKK beta	105	17
IKK epsilon	107	9
IR	116	21
IRAK1	97	14
IRAK4	96	4
IRR	107	5
JAK2	117	1
JNK1	100	5
JNK2	107	9
JNK3	104	1
Lck	101	2
LKB1	138	17
MAP4K3	81	7
MAP4K5	70	15
MAPKAP-K2	88	6
MAPKAP-K3	84	2
MARK1	112	7
MARK2	99	2
MARK3	96	15
MARK4	91	0
MEKK1	104	4
MELK	94	4
MINK1	85	1
MKK1	95	3
MKK2	111	4
MKK6	100	9
MLK1	64	3
MLK3	104	2
MNK1	97	6
MNK2	91	5
MPSK1	98	9
MSK1	96	0
MST2	81	11
MST3	73	11
MST4	75	6
NEK2a	102	9
NEK6	103	1
NUAK1	109	15
OSR1	107	11
p38 alpha MAPK	109	5
p38 beta MAPK	113	0
p38 delta MAPK	99	3
p38 gamma MAPK	102	9
PAK2	117	2
PAK4	92	16
PAK5	107	4
PAK6	106	1
PDGFRA	107	0
PDK1	90	13
PHK	114	1
PIM1	95	11
PIM2	105	7
PIM3	108	7
PINK	79	9
PKA	89	1
PKB alpha	105	3
PKB beta	103	5
PKC alpha	100	4
PKC gamma	98	1
PKC zeta	92	2
PKD1	106	8
PLK1	107	4
PRAK	115	21
PRK2	107	1
RIPK2	98	14
ROCK 2	73	3
RSK1	96	5
RSK2	96	4
S6K1	85	1
SGK1	95	9
SIK2	105	10
SIK3	94	8
SmMLCK	100	4
Src	130	5
SRPK1	103	7
STK33	99	5
SYK	95	1
TAK1	100	2
TAO1	79	10
TBK1	107	5
TESK1	92	6
TGFBR1	108	3
TIE2	76	10
TLK1	97	2
TrkA	90	6
TSSK1	108	9
TTBK1	123	7
TTBK2	89	4
TTK	100	5
ULK1	72	4
ULK2	95	6
VEGFR1	74	10
WNK1	95	1
YES1	87	1
ZAP70	110	2

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	114	1
AMPK	97	1
AMPK (hum)	91	15
ASK1	112	10
Aurora A	98	13
Aurora B	91	5
BRK	72	4
BRSK1	113	7
BRSK2	98	9
BTK	96	2
CAMK1	105	1
CAMKK beta	107	8
CDK2-Cyclin A	88	9
CDK9-Cyclin T1	100	8
CHK1	94	15
CHK2	79	3
CK1 delta	100	5
CK1 gamma 2	99	8
CK2	91	14
CLK2	99	3
CSK	105	5
DAPK1	96	3
DDR2	104	4
DYRK1A	103	4
DYRK2	108	13
DYRK3	78	2
EF2K	96	4
EIF2AK3	103	1
EPH-A2	98	14
EPH-A4	88	9
EPH-B1	92	1
EPH-B2	123	9
EPH-B3	75	24
EPH-B4	100	2
ERK1	90	2
ERK2	79	9
ERK5	103	10
ERK8	85	2
FGF-R1	91	3
GCK	90	5
GSK3 beta	106	15
HER4	105	7
HIPK1	76	8
HIPK2	106	16
HIPK3	80	1
IGF-1R	82	9
IKK beta	104	7
IKK epsilon	88	6
IR	105	24
IRAK1	98	10
IRAK4	96	4
IRR	99	12
JAK2	99	7
JNK1	92	7
JNK2	103	13
JNK3	96	3
Lck	116	5
LKB1	123	5
MAP4K3	82	7
MAP4K5	67	3
MAPKAP-K2	88	15
MAPKAP-K3	75	7
MARK1	94	9
MARK2	95	2
MARK3	104	2
MARK4	88	8
MEKK1	92	4
MELK	103	0
MINK1	93	22
MKK1	96	19
MKK2	99	2
MKK6	88	3
MLK1	67	2
MLK3	106	7
MNK1	93	1
MNK2	95	13
MPSK1	104	10
MSK1	98	4
MST2	77	0
MST3	70	11
MST4	79	6
NEK2a	93	3
NEK6	102	10
NUAK1	104	11
OSR1	106	4
p38 alpha MAPK	111	7
p38 beta MAPK	92	5
p38 delta MAPK	98	1
p38 gamma MAPK	99	7
PAK2	105	1
PAK4	96	3
PAK5	111	9
PAK6	105	4
PDGFRA	90	1
PDK1	90	9
PHK	103	7
PIM1	104	11
PIM2	109	7
PIM3	93	1
PINK	80	3
PKA	109	12
PKB alpha	94	2
PKB beta	95	6
PKC alpha	103	3
PKC gamma	96	4
PKC zeta	91	7
PKD1	109	8
PLK1	113	8
PRAK	105	7
PRK2	92	4
RIPK2	100	20
ROCK 2	61	5
RSK1	87	6
RSK2	87	9
S6K1	88	3
SGK1	99	7
SIK2	97	9
SIK3	106	1
SmMLCK	102	15
Src	117	5
SRPK1	102	11
STK33	105	3
SYK	97	5
TAK1	100	4
TAO1	82	5
TBK1	110	6
TESK1	91	12
TGFBR1	119	22
TIE2	83	2
TLK1	100	8
TrkA	90	10
TSSK1	96	4
TTBK1	113	14
TTBK2	116	17
TTK	91	8
ULK1	72	2
ULK2	88	2
VEGFR1	89	4
WNK1	102	3
YES1	91	3
ZAP70	103	15