Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
AG490   C17H14N2O3 294.30 EGFR, JAK Jaleel M. (2004) Biochemistry 43 8247
Eriksen K.W. (2001) Leukemia 15 787
WO2004052359
10.00 72
AG879 (Tyrphostin)   C18H24N2OS 316.50 Tyrosine-kinases Konrad R.J. (1996) J. Biol. Chem. 271 24179
Levitzki A. Gazit A. (1995) Science 267 1782
WO2003068927
0.10 111
AG879 (Tyrphostin)   C18H24N2OS 316.50 Tyrosine-kinases Konrad R.J. (1996) J. Biol. Chem. 271 24179
Levitzki A. Gazit A. (1995) Science 267 1782
WO2003068927
10.00 85
Akt Inhibitor IV   C31H27IN4S 614.60 Akt Kau T. R. (2003) Cancer Cell 4 463


1.00 101
Akt Inhibitor IV   C31H27IN4S 614.60 Akt Kau T. R. (2003) Cancer Cell 4 463


10.00 112
Akti 1/2   C34H29N7O 551.60 Akt1, Akt2 Logie L. (2007) Diabetes 2218-27
Barnett S.F. (2005) Biochem. J. 385 399
WO2013147649
0.10 86
Akti 1/2   C34H29N7O 551.60 Akt1, Akt2 Logie L. (2007) Diabetes 2218-27
Barnett S.F. (2005) Biochem. J. 385 399
WO2013147649
10.00 88
Akti 1/2   C34H29N7O 551.60 Akt1, Akt2 Logie L. (2007) Diabetes 2218-27
Barnett S.F. (2005) Biochem. J. 385 399
WO2013147649
1.00 79
Akti 1/2   C34H29N7O 551.60 Akt1, Akt2 Logie L. (2007) Diabetes 2218-27
Barnett S.F. (2005) Biochem. J. 385 399
WO2013147649
100.00 61
Alsterpaullone   C16H11N3O3 293.30 GSK3b, CDK5/p25, CDK1/cyclin B Leost M. (2000) Eur. J. Biochem. 267 5983
Schultz C. (1999) J. Med. Chem. 42 2909
EP20050109789
1.00 22