Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Dasatinib   C22H26ClN7O2S 487.00 BCR-ABL, Src, Multiple Tyrosine kinases targeted Kantarjian H. N Engl J Med. (2010) 2260-70

WO2009094556
 1.00 105
Gö 7874   C27H26N4O4 • HCl 507.00 PKC Kleinschroth J. (1995) Bioorg. Med. Chem. Lett. 5 55

US20080153903
 0.10 5
LY333531 (Ruboxistaurin)   C28H28IN4O3 .CH4O3S 582.73 PKC Jirousek M.R. (1996) J. Med. Chem. 39 2664
Tang S. (2008) Proteins 72(1) 447-60
WO2000053013
 0.10 3
SGK-Sanofi-14i   C18H15ClN6O3S SGK Halland, N (2015) ACS Medicinal Chemistry Letters 6 73-78


 1.00 108
SGK1-Sanofi-ex.290-R   C24H25ClN6O5S 545.01 SGK1
WO2014140065
 1.00 113
SU-6668   C18H18N2O3 310.35 Aurora Godl K. (2005) Cancer Res. 65 6919-6926.


 10.00 62
SYK Inhibitor IV (BAY 61-3606)   C20H18N6O3 • HCl • H2O 444.90 SYK Yamamoto N. (2003) J Pharmacol Exp Ther 306 1174


 0.20 57
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

1.00 87
(5Z)-7-Oxozeaenol   C19H22O7 362.37 TAK1 Ninomiya-Tsuji (2003) J.Biol.Chem. 278 18485
Windheim et al (2007) Biochem.J. 404 179

0.10 87
2-Aminopurine   C5H5N5 135.13 PKR

100.00 84