Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 55684 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Screen Conc % Activity Remaining
Bay 65-1942   C22H26ClN3O4 431.91 IKKb Ziegelbauer K. (2005) British Journal of Pharmacology 145 178-192 (compound A)
Moss N.C. (2007) Am J Physiol Heart Circ Physiol 293 H2248-53

1.00 87
BAY-11-7082   C10H9NO2S 207.20 NFKBIA Kamthong P.J. (2001) Biochem. J. 356
Izban K.F. (2000) Hum. Pathol. 31 1482
WO2003072038
1.00 94
BAY-11-7082   C10H9NO2S 207.20 NFKBIA Kamthong P.J. (2001) Biochem. J. 356
Izban K.F. (2000) Hum. Pathol. 31 1482
WO2003072038
10.00 76
Sorafenib   C21H16ClF3N4O3 464.80 Raf, Multiple Tyrosine Kinases Targeted Lyons J.F. (2001) Endocrine Related Cancer 8 3 219-225
Wilhelm S.M. (2004) Cancer Res. 64(19) 7099-109
WO2002085857
10.00 89
BI 2536   C28H39N7O3 521.65 PLK1 Steegmaier M. (2007) Current Biology 17 316-322


10.00 86
BI 2536   C28H39N7O3 521.65 PLK1 Steegmaier M. (2007) Current Biology 17 316-322


0.10 95
BI 2536   C28H39N7O3 521.65 PLK1 Steegmaier M. (2007) Current Biology 17 316-322


1.00 97
BI-78D3   C13H9N5O5S2 379.37 JNK Stebbins J.L. (2008) PNAS 105 16809-16813


0.10 83
BI-78D3   C13H9N5O5S2 379.37 JNK Stebbins J.L. (2008) PNAS 105 16809-16813


10.00 91
BI-78D3   C13H9N5O5S2 379.37 JNK Stebbins J.L. (2008) PNAS 105 16809-16813


1.00 71